Ubiquitin ligase NEDD4 promotes the proliferation of hepatocellular carcinoma cells through targeting PCDH17 protein for ubiquitination and degradation

Liu, Zhiyi; Hu, Qinghe; Hu, Bin; Cao, Kuan; Xu, Tao; Hou, Tianqi; Cao, Tong; Wang, Renhao; Shi, Hengliang; Zhang, Bin

doi:10.1016/j.jbc.2023.105593

Cited by 2 publications

(1 citation statement)

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“…Zhaowei Qu et al conducted a comprehensive bioinformatics study on the potential molecular mechanisms of TGF-β activation in HCC cells, and found that TGF-β may affect the biological processes of HCC cells via regulatory pathways such as SMAD2/SMAD3-NEDD4 and HNF4A-CUL4 B/NEDD4, which provides a new direction for further research on HCC [140]. Zhiyi Liu et al reported that NEDD4 could regulate the ERK signaling pathway by inducing the ubiquitination degradation of protocadherin 17 (PCDH17), which would then promote the proliferation of HCC cells [101]. Surprisingly, another study revealed that the expression of NEDD4L was downregulated in HCC tissues compared with paraneoplastic tissues, and by analyzing the relationship between NEDD4L and the clinicopathological features of HCC patients, NEDD4L was shown to exert a tumor suppressor effect in HCC by triggering MAPK/ERK-mediated apoptosis.…”

Section: Nedd4/neddl and Liver Diseases 221 Nedd4/neddl And Liver Cancermentioning

confidence: 99%

NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases

Xu,

Jiang,

et al. 2024

Biomolecules

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Protein ubiquitination is an enzymatic cascade reaction and serves as an important protein post-translational modification (PTM) that is involved in the vast majority of cellular life activities. The key enzyme in the ubiquitination process is E3 ubiquitin ligase (E3), which catalyzes the binding of ubiquitin (Ub) to the protein substrate and influences substrate specificity. In recent years, the relationship between the subfamily of neuron-expressed developmental downregulation 4 (NEDD4), which belongs to the E3 ligase system, and digestive diseases has drawn widespread attention. Numerous studies have shown that NEDD4 and NEDD4L of the NEDD4 family can regulate the digestive function, as well as a series of related physiological and pathological processes, by controlling the subsequent degradation of proteins such as PTEN, c-Myc, and P21, along with substrate ubiquitination. In this article, we reviewed the appropriate functions of NEDD4 and NEDD4L in digestive diseases including cell proliferation, invasion, metastasis, chemotherapeutic drug resistance, and multiple signaling pathways, based on the currently available research evidence for the purpose of providing new ideas for the prevention and treatment of digestive diseases.

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Section: Nedd4/neddl and Liver Diseases 221 Nedd4/neddl And Liver Cancermentioning

confidence: 99%