Ubiquitous and multifaceted: SIT53 spoligotype does not correlate with any particular family of Mycobacterium tuberculosis

Mokrousov, Igor

doi:10.1016/j.tube.2020.102024

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…This fact was evidenced by 12 strains carrying the fbpC103 variant, a known LAM marker, and by the position in the phylogenetic tree. Moreover, the ill-defined family T assigned by spoligotyping, especially the spoligotype SIT53, has been demonstrated previously as a common pattern for different sublineages in Lineage 4 [36] .…”

Section: Discussionmentioning

confidence: 70%

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

Salvato¹,

Reis²,

Schiefelbein³

et al. 2021

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 70%

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

Salvato¹,

Reis²,

Schiefelbein³

et al. 2021

International Journal of Antimicrobial Agents

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“…According to our global analysis, SIT53 showed an increase in Cameroon and Chad, and a very high rate in Niger and Ghana ( Fig 3 ). However, one should keep in mind that SIT53 is a heterogeneous group of distantly related strains otherwise found on different branches of the L4 tree based on genome-wide SNPs [ 34 ]. The SIT53 populations from diverse geographical locations most likely represent unrelated branches that evolved from ancestral SIT53 over historically long time [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, one should keep in mind that SIT53 is a heterogeneous group of distantly related strains otherwise found on different branches of the L4 tree based on genome-wide SNPs [ 34 ]. The SIT53 populations from diverse geographical locations most likely represent unrelated branches that evolved from ancestral SIT53 over historically long time [ 34 ]. In this sense, SIT53 populations in different parts of Africa may represent unrelated genotypes.…”

Section: Discussionmentioning

confidence: 99%

Molecular snapshot of drug-resistant Mycobacterium tuberculosis strains from the Plateau State, Nigeria

et al. 2022

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Nigeria ranks 1st in Africa and 6th globally with the highest burden of tuberculosis (TB). However, only a relatively few studies have addressed the molecular epidemiology of Mycobacterium tuberculosis in this country. The aim of this work was to analyze the genetic structure of drug-resistant (DR) M. tuberculosis population in the Plateau State (central Nigeria), with the results placed in the broader context of West Africa. The study sample included 67 DR M. tuberculosis isolates, recovered from as many TB patients between November 2015 and January 2016, in the Plateau State. The isolates were subjected to spoligotyping and MIRU-VNTR typing. A total of 20 distinct spoligotypes were obtained, split into 3 clusters (n = 50, 74.6%, 2–33 isolates per cluster) and 17 (25.4%) unique patterns. The Cameroon clade was the largest lineage (62.7%) followed by T (28.3%), LAM (3%), and Haarlem (3%) clades. Upon MIRU-VNTR typing, the isolates produced 31 profiles, i.e. 7 clusters (n = 43, 64.2%, 2–17 isolates per cluster) and 24 singletons. A combined spoligotyping and MIRU-VNTR typing analysis showed 20.9% of the cases clustered and estimated the recent transmission rate at 11.9%. In conclusion, two lineages, namely Cameroon, and T accounted for the majority (91%) of cases. No association was observed between the most prevalent Cameroon lineage and drug resistance, including multidrug resistant (MDR) phenotype, or any of the patient demographic characteristics.

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Antimycobacterial compounds produced by forest fungi: An overview

Meskini,

Rami,

Ghosh

2025

Forest Fungi

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Ubiquitous and multifaceted: SIT53 spoligotype does not correlate with any particular family of Mycobacterium tuberculosis

Cited by 9 publications

References 26 publications

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

Molecular snapshot of drug-resistant Mycobacterium tuberculosis strains from the Plateau State, Nigeria

Antimycobacterial compounds produced by forest fungi: An overview

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