Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens

Petersen, Arnd; Vieths, Stefan; Aulepp, H; Schlaak, M; Becker, Wolf‐Meinhard

doi:10.1016/s0091-6749(96)70130-6

Cited by 124 publications

(111 citation statements)

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“…Petersen et al (25) identified the main tomato allergens using sera from 8 subjects with high the grass-pollen sensitized subjects, the percentage of subjects reactive to tomato extract comes to ~54%. Out of the 95 subjects who showed cross-sensitization to both grass pollen and tomato extracts, 82 subjects (92% of subgroup) showed positive SPT with affinity-purified tomato profilin ( Figure 5, panel b).…”

Section: Discussionmentioning

confidence: 99%

“…Possibly connected with the sequence diversity, ubiquity, and abundance of profilins in eukaryotes is the fact that plant profilins are important cross-reactive allergens, and are identified as pan-allergens (23). The prevalence of tomato (Solanum lycopersicum L.) allergy was estimated to range from 1.5% to 16% among food-allergic populations (24)(25)(26)(27), and up to 39.2% among grass pollen-allergic patients (28). Profilin from tomato fruit (14 kDa; Sola l 1) has been identified as a food allergen, and has been cloned and characterized (29,30).…”

Section: Allergic Subjects and Case Historymentioning

confidence: 99%

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Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

Hegde

Modesti²,

Venkatesh

2018

Eur Ann Allergy Clin Immunol

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SummaryThe association between grass pollen sensitization and food allergy to tomato is of great interest. We report here, the first such study in Indian population. We investigated 246 allergic rhinitis / asthma patients by diagnostic case history and skin prick test (SPT); grass pollen mix, tomato extract and purified tomato profilin were used for SPT. Tomato profilin was purified by affinity chromatography, and analyzed by HPLC (95% purity) and SDS-PAGE (14 kDa).We observed that 38% of the patients had sensitization to both grass pollen and tomato fruit, of which 92% were sensitized to tomato profilin. Among patients with a history of food allergy to tomato fruit, the association was more pronounced (66%). Tomato profilin appears to be an important cross-sensitizing panallergen in respiratory allergic patients in the Indian subcontinent.

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Section: Discussionmentioning

confidence: 99%

Section: Allergic Subjects and Case Historymentioning

confidence: 99%

Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

Hegde

Modesti²,

Venkatesh

2018

Eur Ann Allergy Clin Immunol

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“…These results showed a cross-reactivity between CJ and tomato allergens in the dog. Petersen et al reported IgE cross-reactivity between grass pollen and tomato allergens in human patients with grass pollinosis [9]. As well, Kondo et al reported IgE crossreactivity between CJ and tomato allergens in human patients with CJ pollinosis [4].…”

mentioning

confidence: 99%

Oral Allergy Syndrome Induced by Tomato in a Dog with Japanese Cedar (Cryptomeria japonica) Pollinosis.

Fujimura¹,

Ohmori

Masuda

et al. 2002

The Journal of Veterinary Medical Science

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ABSTRACT. A dog with Japanese cedar (Cryptomeria japonica, CJ) pollinosis had oral allergy syndrome (OAS) after ingesting fresh tomato. The dog showed specific IgE to both CJ and tomato allergens. As a negative control, twenty dogs without atopic dermatitis that had no exposure to tomato and no specific IgE to CJ allergen were used. They had no specific IgE to tomato allergen. Furt hermore, IgE cross-reactivity was observed between CJ and tomato allergens in the dog. We found that OAS induced by tomato exists in the dog and there is a relationship between CJ and tomato allergens. KEY WORDS: oral allergy syndrome, pollen, tomato.J. Vet. Med. Sci. 64(11): 1069-1070, 2002 In Japan, Japanese cedar (Cryptomeria japonica, CJ) pollinosis is one of the most common human allergic diseases [3]. CJ pollinosis has also been reported in dogs in Japan [10]. Our recent epidemiological study reported that approximately 20% of atopic dogs had specific IgE to crude CJ allergen [7]. Furthermore, dogs sensitive to CJ allergen showed blastogenesis and histamine release from peripheral leukocytes specific to this pollen antigen [5]. These findings suggested that CJ allergen might be associated with the pathogenesis of atopic dermatitis in dogs.Human patients showed oral allergy syndrome (OAS) after eating fruits and vegetables [1]. In human pollinosis patients, sensitivity to fruits and vegetables as OAS was reported [8]. Furthermore, there has been reported the association between some pollinosis and OAS in regard to fruits such as apple, orange, tomato, grape [2,11]. Recently, it is suggested that there is an association between human CJ pollinosis and tomato (Lycopersicon escletum) allergy [4]. However, there has been no report on OAS in dogs. In this study, we found that a dog with CJ pollinosis showed OAS induced by tomato.A 6-years-old male mixed-breed dog showed typical lesions of chronic dermatitis including erythema, eczema, and hair-loss with severe pruritus during April to October. The dog showed severer symptoms during the season of CJ pollenation. Specific IgE to both crude CJ and tomato allergens were assayed by a fluorometric ELISA as described previously [6]. Fresh tomato was washed well with water and rinded. Next, the tomato was dissected and homogenized. After centrifugation and filtration through a 0.22-µm membrane, the tomato extract was used as an ELISA antigen. The dog had specific IgE to both CJ and tomato allergens (Fig. 1). As a negative control, 20 healthy dogs without specific IgE to CJ allergen were used. There was no history of exposure to tomato in the dogs. The 20 control dogs showed no specific IgE to tomato allergens (Fig. 1). In this study, interdermal skin test could not be performed.Since the dog with atopic dermatitis had been treated with elimination diets (Eukanuba veterinary diets dry dog food, Response TM FP/Canine, Iams Co., Dayton, U.S.A.) for the last 3 years, it is considered that the dog has not been exposed to tomato. Oral provocation test was performed to * CORRESPONDENCE TO: DR. SAKAG...

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“…some vegetable or invertebrate glycoproteins (Aalberse et al, 1981a,b;Koshte et al, 1989;Aalberse, 1992Aalberse, , 1995Aalberse and Van Ree, 1996;Petersen et al, 1996;Vieths and Schö ning, 1996) are usually, but not necessarily, non-sensitizing) reacts with IgE on the mast cell, but this interaction does not trigger the mast cell to degranulate. The reasons for this lack of mast cell stimulation are unclear, but might possibly be related to monovalency of the allergen.…”

Section: Non-elicitormentioning

confidence: 99%

Food allergens

Aalberse

1997

Environmental Toxicology and Pharmacology

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A food allergen may be defined as a substance that reacts with IgE antibodies, induces allergic sensitisation or induces allergic reactions. Some allergens only induce allergic sensitisation but do not provoke symptoms, while others bind IgE but do not induce mast cell degranulation. There is no common structure that can predict whether a given antigen may be a strong food allergen. A complete food allergen, e.g. fish parvalbumin, is capable of stimulating the immune system to produce IgE antibodies, and degranulate mast cells upon subsequent contact. The reason(s) for why some patients with IgE to ovalbumin tolerate eggs, and why some react on one occasion but not on another, are mostly unclear, but may be related to changes in gut permeability induced by other food substances or by gastro-intestinal inflammation prior to the allergen contact. IgE antibodies to fruit or vegetables often show cross-reactivity, due to carbohydrate structures. These cross-reactive glycans have been designated cross-reactive carbohydrate determinants (CCD). Anti-CCD antibodies are highly cross-reactive. The antibodies do not have clinical significant because CCD-containing foods are usually well-tolerated by patients with IgE antibodies to CCD. These IgE antibodies may cause confusion in relation to allergy diagnosis. © 1997 Elsevier Science B.V.

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Ubiquitous structures responsible for IgE cross-reactivity between tomato fruit and grass pollen allergens

Cited by 124 publications

References 36 publications

Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

Skin prick test analysis reveals cross-sensitization to tomato profilin and grass pollen in nasobronchialallergic patients with history of tomato food allergy

Oral Allergy Syndrome Induced by Tomato in a Dog with Japanese Cedar (Cryptomeria japonica) Pollinosis.

Food allergens

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