“…1 These techniques include nanomechnical oscillators 2,3 and a variety of approaches based on more traditional mass spectrometry methods. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Charge detection mass spectrometry (CDMS), which offers a good compromise between resolution, accuracy, and measurement speed, is one of the more promising approaches. [20][21][22][23][24][25][26][27][28][29][30][31] In particular, CDMS has recently been used to measure the molecular weight distributions for a number of heterogeneous, high-mass samples including amyloid fibrils, 32 synthetic polymers, 33 nanoparticles, 34 gene therapy products, 35 and viruses and virus assembly intermediates.…”