Uddanam Kidney Nephropathy Under the Light of Metagenomics Perspective

Abstract

In this work, we proposed a research hypothesis which mainly focuses on the role of gut microbiota, in relation with chronic kidney disease, existing in the village of Uddanam belonging to the State of Andhra Pradesh, India. Earlier studies conducted on various physical and chemical parameters, such as food, water, soil and pesticides, could not find the exact cause of the aetiology of the disease. As there were no physical and chemical causative factors identified, this disease was hence named as mysterious Uddanam kidney nephropathy of unknown origins. There are few scientific pieces of evidence available in the literature, which suggests the role of gut microbiome dysbiosis and its impact on kidney disease. Such kinds of scientific studies which deal with the analysis of microbial communities of the gut region and identification of dysbiosis were not performed in the case of Uddanam kidney nephropathy. Thus, through this paper, we propose a hypothesis to analyse and establish the relationship between the gut dysbiosis and renal failure by performing the metagenomics study between the patients and the normal individuals. To the best of our knowledge, there are no reports available to date on the dysbiosis of the gut microbiome and its impact on Uddanam nephropathy and hence this research hypothesis is thus proposed.

Assessment of Knowledge of Causes, Signs and Symptoms as a Determinant of Kidney Failure Risk Behaviour Among Workers in Ede North Local Government Area of Osun State, Nigeria

“…Data related to the cause of ESRD reported at the state hospital in Ede land revealed that over 13700 cases of hypertension, diabetes, and some infections were reported between 2007 and 2014 (8). According to Gross, Azevedo, and Silveiro diabetic nephropathy is the leading cause of chronic kidney disease in patients starting renal replacement therapy and it is associated with increased cardiovascular mortality (9)(10)(11)(12). Also, reported in their study that hypertension is the second leading cause of chronic kidney disease in all developed and many developing countries but glomerulonephritis and unknown causes are more common in countries of Asia and sub-Saharan Africa (SSA) (1,(9)(10)(11).…”