Ueber Chindolin

Fichter, Fr.; Boehringer, Rudolf

doi:10.1002/cber.19060390475

Cited by 31 publications

(29 citation statements)

References 6 publications

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“…Cryptolepine is present in relatively large amounts in the roots of C. sanguinolenta (>1% of the dried roots), and it has potent in vitro activities against both chloroquine-sensitive and chloroquine-resistant P. falciparum (Wright et al, 2001). The synthesis of cryptolepine is straightforward and was in fact accomplished before the alkaloid was isolated from natural sources (Fichter and Boehringer, 1906), thus giving potential for the preparation of cryptolepine analogues for assessment as antimalarials. These features would suggest that cryptolepine may be a viable lead compound, but this alkaloid unfortunately has other less promising attributes.…”

Section: Cryptolepine -A Lead To New Antimalarial Agents?mentioning

confidence: 99%

Plant Derived Antimalarial Agents: New Leads and Challenges

Wright

2005

Phytochem Rev

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New treatments for malaria are urgently needed due to the increasing problem of drug-resistance in malaria parasites. The long-established use of quinine and the more recent introduction of artemisinin and its derivatives as highly effective antimalarials demonstrates that plant species are an important resource for the discovery of new antimalarial agents. Furthermore, many plant species continue to be used in traditional medicines for the treatment of malaria and many people depend on such remedies as they cannot afford and/or do not have access to effective antimalarial drugs. In this paper the potential of plant species to yield new leads to antimalarial drugs will be illustrated with reference to cryptolepine, the main alkaloid present in the species, Cryptolepis sanguinolenta. In addition to this approach, there is currently increasing interest in the use and development of traditional herbal remedies for the treatment of malaria as these may have the potential to provide affordable antimalarial treatment for many who cannot afford the drugs needed to treat chloroquine-resistant Plasmodium falciparum infections. However, little is known with respect to the efficacy and safety of traditional antimalarials and clinical studies are urgently needed to establish their value. Some of the issues pertinent to this area will be briefly reviewed and it is hoped that this will stimulate further discussion and research on this important topic.

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Section: Cryptolepine -A Lead To New Antimalarial Agents?mentioning

confidence: 99%

Plant Derived Antimalarial Agents: New Leads and Challenges

Wright

2005

Phytochem Rev

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“…cryptolepine (1) In order to facilitate further chemical and biological evaluation of these compounds (currently going on in these laboratories), we now report the full 1H-and 13C-NMR assignments of cryptolepine.…”

Section: Ch3mentioning

confidence: 99%

¹H-NMR and¹³C-NMR Assignments of Cryptolepine, A 3:4-Benz-δ-carboline Derivative Isolated fromCryptolepis sanguinolenta

et al. 1990

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Cryptolepine (1), a 3 : 4-benz-ô-carboline derivative, was synthesized (1) and then isolated from Cryptolepis triangularis (2) several years ago. In 1978, Dwuma-Badu and others (3) isolated cryptolepine from the roots of the West African plant Cryptolepis sanguinolenta (Lindl.) Schlecter, which began a whole new series of investigations into the constituents of C. sanguinolenta. Biological evaluation (4) of cryptolepine confirms the use of the plant as an antimicrobial agent (5) by West African natives. Cryptolepine also has reported hypotensive (6), antipyretic

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“…Cryptolepine is a rare example of a natural product where synthesis was reported prior to its isolation from nature. It was first synthesized in 1906 by Fichter and coworkers and its isolation was first reported by Clinquart in 1929 from Cryptolepis Triangularis [1,4,5]. As cryptolepine possesses a number of biological activities many analogues have been synthesized to identify its pharmacophoric groups.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of novel halogenated cryptolepine analogues

Gouni¹,

Carrington²,

Wright³

2006

Journal of Heterocyclic Chem

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Cryptolepine (5-N-methyl-10-H-indolo [3,2-b]quinoline) is an indoloquinoline alkaloid present in the roots of Cryptolepis Sanguinolenta. In its hydrochloride form the alkaloid presents a number of bioactivities. The alkaloid also has cytotoxic properties that are likely to be due to its abilities to intercalate into DNA and inhibit the enzyme topoisomerase II, as well as the synthesis of DNA. In this research project five novel analogues of cryptolepine were chosen for synthesis.

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Ueber Chindolin

Cited by 31 publications

References 6 publications

Plant Derived Antimalarial Agents: New Leads and Challenges

Plant Derived Antimalarial Agents: New Leads and Challenges

¹H-NMR and¹³C-NMR Assignments of Cryptolepine, A 3:4-Benz-δ-carboline Derivative Isolated fromCryptolepis sanguinolenta

Synthesis of novel halogenated cryptolepine analogues

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Ueber Chindolin

Cited by 31 publications

References 6 publications

Plant Derived Antimalarial Agents: New Leads and Challenges

Plant Derived Antimalarial Agents: New Leads and Challenges

1H-NMR and13C-NMR Assignments of Cryptolepine, A 3:4-Benz-δ-carboline Derivative Isolated fromCryptolepis sanguinolenta

Synthesis of novel halogenated cryptolepine analogues

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¹H-NMR and¹³C-NMR Assignments of Cryptolepine, A 3:4-Benz-δ-carboline Derivative Isolated fromCryptolepis sanguinolenta