Ueber das Gebirgsklima

Virchow,

doi:10.1007/bf02012886

Cited by 2 publications

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“…The CSC hypothesis represents a modern‐day interpretation of the proposal made by Rudolph Virchow and Julius Cohnheim that cancer results from the activation of dormant embryonal‐rest cells (Virchow, 1855; Cohnheim, 1867). Accordingly, we next proceeded to examine, in CSCs from Scal‐BCR‐ABLp210 mice, the expression of embryonic surface markers, the presence of which has been identified earlier in undifferentiated mouse embryonic stem cells (Nunomura et al , 2005) (Figure 3B).…”

Section: Resultsmentioning

confidence: 99%

Cancer induction by restriction of oncogene expression to the stem cell compartment

Pérez-Caro

Cobaleda

González-Herrero

et al. 2008

EMBO J

119

142

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In human cancers, all cancerous cells carry the oncogenic genetic lesions. However, to elucidate whether cancer is a stem cell-driven tissue, we have developed a strategy to limit oncogene expression to the stem cell compartment in a transgenic mouse setting. Here, we focus on the effects of the BCR-ABLp210 oncogene, associated with chronic myeloid leukaemia (CML) in humans. We show that CML phenotype and biology can be established in mice by restricting BCR-ABLp210 expression to stem cell antigen 1 (Sca1) þ cells. The course of the disease in Sca1-BCRABLp210 mice was not modified on STI571 treatment. However, BCR-ABLp210-induced CML is reversible through the unique elimination of the cancer stem cells (CSCs). Overall, our data show that oncogene expression in Sca1 þ cells is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that elimination of the CSCs is enough to eradicate the whole tumour.

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Section: Resultsmentioning

confidence: 99%

Cancer induction by restriction of oncogene expression to the stem cell compartment

Pérez-Caro

Cobaleda

González-Herrero

et al. 2008

EMBO J

119

142

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“…Since 1884, only one theory, known as Virchow's theory and still referred to, has been proposed, namely, reversion of renal capsular connective tissue to pluripotent embryonic mesenchyme and re-differentiation to osteosarcoma. 5 Commonly reported symptoms include flank pain, gross hematuria, and constitutional symptoms such as weakness, fatigue, and weight loss. Our patient was found to have gross hematuria.…”

Section: Discussionmentioning

confidence: 99%

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

et al. 2023

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Extraskeletal osteosarcoma (ESOS) is a very rare entity among renal malignancies. There are few reports of renal ESOS in the database. Renal ESOS was found to have a high rate of local recurrence and distant metastasis. In most reports, the overall survival of patients was less than 1 year. We present a 51-year-old man who presented with gross hematuria and a clinical diagnosis of a staghorn stone in the left kidney. He underwent radical nephrectomy. The pathologic diagnosis of osteosarcoma was evident.

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Ueber das Gebirgsklima

Cited by 2 publications

References 0 publications

Cancer induction by restriction of oncogene expression to the stem cell compartment

Cancer induction by restriction of oncogene expression to the stem cell compartment

A staghorn kidney stone or extraskeletal osteosarcoma of the kidney? A case report and literature review

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