Ueber das weibliche Sexualhormon, das Hormon des östrischen Zyklus (Menformon)¹⁾. IV. Einfluß auf den Stoffwechsel, Widerstandsvermögen gegen physikalische und andere Eingriffe²⁾

Abstract

Ueber das weibliche Sexualhormon, das Hormon des östrischen Zyklus (Menformon) '). IV.Einfluß auf den StoffwechseJ, Widerstandsvermögen gegen physikalische und andere Eingriffe 2).

Peripheral Vascular Action of Estrogen in the Human Male 1

“…While it is generally recognized that estrogens are without demonstrable effect upon the mean level of arterial blood pressure (8,9,10,11,14,15), evidence is accumulating to show that the effects of estrogen on the peripheral circulation are quite widespread throughout the body, and are of a definite character. The following facts indicate this: the injection of estrogen causes swelling and changes in the water content of the sex-skin in certain primates (12); estrogen causes engorgement of the vessels in the nasal mucosa, including that of women (13); the injection of estrogen in the human is followed by a fall in capillary pressure and dilatation of the nail-bed capillary vessels (14); estrogen causes a decrease of venous pressure in the hand (15); and, finally, estrogen causes a change in the water content of the skin of the rat within a few hours (16) which is qualitatively comparable to that occurring in the uterus and vagina (16,17).…”

The Internal Secretions of the Ovary

“…Gastrin resists the lipases of plants (166), of the pancreas, and of the liver (167). Laqueur, Hart, and de Jongh (346) confirmed these facts on their watersoluble products, which also showed resistance to pepsin.…”

“…Doisy, Ralls, Allen, and Johnston (167) reported resistance to saponification by sodium ethylate and this has been confirmed by many workers. Laqueur, Hart, and de Jongh (344) boiled purified preparations with 26 '^^KOH and 26% H2SO4 without causing destruction, and the same authors (346) showed that it resisted 10 ",j KOH up to 170°C. Other THE CESTRUS-PRODUCING HORMONE 91 agents to which it is resistant include NaOH (230), and sodium methylate and butylate (166,167).…”

“…The active substance is resistant to qo INTERNAL SECRETIONS OF THE OVARY comparatively high temperatures, though the exact temperature at which destruction takes place appears to vary with the nature of the impurities. Laqueur, Hart, and de Jongh (346) found that their less pure preparations resisted up to 360°C, but that the purified aqueous solution was inactivated at 170°C.…”

“…Effect on circulation. According to Allen and co-workers (24), Fraenkel (212), Laqueur (346), Doisy, Ralls, and Jordan (166) and Brouha and Simonnet (93), the effect of oestrin on blood pressure is negligible, though crude extracts have a depressor effect.…”