Ueber die Einwirkung von Diazobenzolimid auf Acetylendicarbonsäuremethylester

Michael, Arthur

doi:10.1002/prac.18930480114

Cited by 209 publications

(123 citation statements)

References 2 publications

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“…The azide-alkyne 1,3-dipolar cycloaddition (or the 1,3-Huisgen reaction 67 ) was identified as the 'cream of the crop' of 'click' reactions. Despite this reaction being first reported in 1893, 68 the non-selective formation of both 1,4-and 1,5-substituted 1,2,3-triazoles led to minimal applications of these compounds. This setback was largely overcome by the development of the CuAAC reaction 66,69 which is a regioselective, high yielding and tolerant reaction, exclusively giving 1,4-disubstituted 1,2,3-triazole products.…”

Section: Terdentate Ligandsmentioning

confidence: 99%

The btp [2,6-bis(1,2,3-triazol-4-yl)pyridine] binding motif: a new versatile terdentate ligand for supramolecular and coordination chemistry

2014

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Ligands containing the btp [2,6-bis(1,2,3-triazol-4-yl)pyridine] motif have appeared with increasing regularity over the last decade. This class of ligands, formed in a one pot 'click' reaction, has been studied for various purposes, such as for generating d and f metal coordination complexes and supramolecular self-assemblies, and in the formation of dendritic and polymeric networks, etc. This review article introduces btp as a novel and highly versatile terdentate building block with huge potential in inorganic supramolecular chemistry. We will focus on the coordination chemistry of btp ligands with a wide range of metals, and how it compares with other classical pyridyl and polypyridyl based ligands, and then present a selection of applications including use in catalysis, enzyme inhibition, photochemistry, molecular logic and materials, e.g. polymers, dendrimers and gels. The photovoltaic potential of triazolium derivatives of btp and its interactions with anions will also be discussed.

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Section: Terdentate Ligandsmentioning

confidence: 99%

The btp [2,6-bis(1,2,3-triazol-4-yl)pyridine] binding motif: a new versatile terdentate ligand for supramolecular and coordination chemistry

2014

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“…A primeira reação deste tipo foi realizada por Arthur Michael, que isolou por destilação o produto formado pela reação entre a fenil-azida 33 (preparada em 1893) e o acetilenodicarboxilato de etila (34) (Esquema 6) 25 .…”

Section: Metodologia Via Osazonaunclassified

Heterociclos 1,2,3-triazólicos: histórico, métodos de preparação, aplicações e atividades farmacológicas

Melo¹,

Donnici²,

Augusti³

et al. 2006

Quím. Nova

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Recebido em 7/4/05; aceito em 21/7/05; publicado na web em 16/2/06 1,2,3-TRIAZOLIC HETEROCYCLES: HISTORY, PREPARATIONS, APPLICATIONS AND PHARMACOLOGICAL ACTIVITIES. The 1,2,3-triazole, known since the end of 19 th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization -and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles.

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“…In 2002, the groups of Sharpless 68 and Meldal 69 independently reported a stepwise modification of a classical reaction of organic chemistry, the Huisgen 70 -Dimroth 71 -Michael 72 1,3-dipolar-cycloaddition between an azide and alkyne. They found that triazole formation was dramatically accelerated by the use of copper(I) even at room temperature, and was highly tolerant of both water While less common, other miscellaneous but nonetheless illustrative reactions exist for modifying both natural and unnatural amino acids in a site-selective fashion.…”

Section: Modifications At Uaasmentioning

confidence: 99%