Ueber Knochenbildung in der Arterienwand

Mönckeberg, J. G.

doi:10.1007/bf01994928

Cited by 29 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, cartilage is present in the heart of mice and rats (Hueper, 1939), rabbits (Kern, 1927), Syrian hamsters (Kelsall & Visci, 1970), and serpents (Young, 1994). Textbooks of human anatomy (Schaffer, 1930 ;Benninghoff, 1994) describe a cartilage-like structure in the centre of the right fibrous trigone of the human heart referring to findings of Tandler (1913) and Mo$ nckeberg (1902).…”

Section: mentioning

confidence: 99%

Bones in the heart skeleton of the otter (Lutra lutra)

Egerbacher

Weber²,

Hauer

2000

Journal of Anatomy

View full text Add to dashboard Cite

In most mammalian species the cardiac skeleton is composed of coarse collagen fibres, fibrocartilage, and pieces of hyaline cartilage. Bone, the os cordis, is a regular constituent of the ruminant heart. The cardiac skeleton of the otter (Lutra lutra) has not previously been described. The skeleton in 30 otter hearts was studied by -ray analysis and light microscopy. Serial sections were cut parallel to the atrioventricular plane and histochemical staining methods were performed to identify connective tissue fibres, glycosaminoglycans, mineral deposits, and bone. Age and sex of the animals under investigation were considered. The otter heart skeleton was composed of coarse collagen fibres with intercalated pieces of fibrous and\or hyaline cartilage, calcified cartilage, and lamellar bone with red or white marrow. Pieces of hyaline cartilage were not clearly defined : a perichondrial layer was missing and coarse connective tissue continuously transformed into fibrous and hyaline cartilage. In both sexes the amount of cartilage and bone were found to increase with age.Our results establish the presence of bony material in the heart skeleton of the otter, a small mammalian species. This finding indicates that differentiation of bone is not exclusively related to the size of the organ. Increasing amounts of calcified cartilage and bone correlated with increasing age.Key words : Cardiac skeleton ; os cordis ; cartilage ; extracellular matrix. The musculature of the atrial and ventricular walls is inserted into the cardiac skeleton, which comprises the fibrous rings (annuli fibrosi) and the fibrous trigone (trigona fibrosa). The fibrous rings are mainly composed of interwoven bundles of collagen fibres with a few elastic fibres surrounding the atrioventricular openings and the openings of aorta and pulmonary artery. The fibrous trigones consist of areas of dense connective tissue between the aorta and the atrioventricular openings and are connected by the aortic-mitral curtain. The right trigone, together with the membranous septum, constitutes the central fibrous body (Gray, 1995). In certain mammalian species, the trigones contain fibrocartilage, hyaline cartilage, and even bony material. The latter forms a right and left cardiac bone (os cordis) related to the trigone between atrioventricular ostia and the aortic Correspondence to Dr M. Egerbacher,

show abstract

Section: mentioning

confidence: 99%

Bones in the heart skeleton of the otter (Lutra lutra)

Egerbacher

Weber²,

Hauer

2000

Journal of Anatomy

View full text Add to dashboard Cite

show abstract

“…We are approaching an understanding of vascular calcification, which was described in exquisite detail already in the late 19 th and early 20 th century [1–3]. Thos early studies predicted and posed the questions that are still actively being studied today.…”

Section: Introductionmentioning

confidence: 99%

Where do we stand on vascular calcification?

Boström

2016

Vascular Pharmacology

View full text Add to dashboard Cite

Vascular disease, such as atherosclerosis and diabetic vasculopathy, is frequently complicated by vascular calcification. Previously believed to be an end-stage process of unregulated mineral precipitation, it is now well established to be a multi-faceted disease influenced by the characteristics of its vascular location, the origins of calcifying cells and numerous regulatory pathways. It reflects the fundamental plasticity of the vasculature that is gradually being revealed by progress in vascular and stem cell biology. This review provides a brief overview of where we stand in our understanding of vascular calcification, facing the challenge of translating this knowledge into viable preventive and therapeutic strategies.

show abstract

“…Calcification of animal hearts is known as a pathology (1,4,7,12), whereas partial calcification is described in various areas of the heart, especially in the aortic wall. In the intima of an aged human aorta, the presence of a calcified piece with sclerotic complications was described (9). On seven human autopsy cases after traffic deaths (21-61 years old) no trace of heart bone was observed.…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, the presence of chondrification has been found in the heart of hamsters (5), birds (8) and even frogs (1), and bony tissues have been found in the heart of cows, birds (8) and humans (2,9). Most cases are reported as cartilage pieces, and reports on bone formation are exceptional.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Hematopoiesis in Bovine Heart Bone

Yamada

Takeuchi

Yamamoto

et al. 1977

Cell Struct. Funct.

View full text Add to dashboard Cite

ABSTRACT. In the bovine heart, chondrification of the fibrous tissue occurs just after birth and proceeds to bony tissue. The ossification appears first in the right fibrous trigonum three months after birth and then in the left trigonum twelve months after birth. During ossification, the bone marrow structure appears to form a narrow space within the bony tissue and develops during the subsequent year. Light and electron microscopic examinations revealed development of typical hematopoiesis in the heart bone marrow. Hemoglobin was estimated in various erythroid cells by cytospectral analysis. The hematopoietic activity was retained for about 10 years in the heart bone.The presence of cartilage in the heart has been known in man (2) and in vertebrates, e.g., the cow (6, 8), hamster (5), rat (3, 4), bird (8) andeven in the frog (1) and fish (8). In most animals, cartilage appears in peculiar loci of the heart. However, the heart bone was observed as an ossified plate in the fibrous annulus surrounding the base of the aorta (8, 9). In rare cases of avian heart (8), chondrification forms a bony piece involving bone marrow space. The details on the formation of heart bone marrow structure have yet not been described. In dissections of many bovine hearts, we found bone marrow structures and have elucidated the hematopoiesis in the structures. This paper also reports on heart bone hematopoiesis at various age periods by cytospectral analysis of erythroid cells. MATERIALS AND METHODSTwenty-seven hearts were dissected from domestic Bos at sacrifice. The examined age range was from newborn to 10 years old and consisted of males, females and castrated males ( Table 1). The heart bones were carefully resected from the base of the aorta and pulmonary trunk. The resected bones were cut into small pieces and fixed with 2.5 % glutaraldehyde in 0.1 M phosphate buffer, pH, 7.2, for 1 h at 4° C and examined by electron microscopy. For ordinary histologic examination, the bony pieces were fixed with 10% formalin in 0.1 M phosphate buffer, pH 7.2, then decalcified with 2 % citric acid solution saturated with EDTA-2Na for several days and postfixed with Zenker's fluid. The tissueswere embedded in celloidin-paraffin, sectioned at 15,u and stained with hematoxylin and eosin. The cut face of the raw bone was stamped on a glass slide, dried, fixed with methanol and prepared by Wright stain for blood cell diagnosis. Some samples were applied for cytospectral identification of immature erythrocytes. Cytospectral analysis was carried out by the relative wavelength-scanning method, 353

show abstract

Ueber Knochenbildung in der Arterienwand

Cited by 29 publications

References 4 publications

Bones in the heart skeleton of the otter (Lutra lutra)

Bones in the heart skeleton of the otter (Lutra lutra)

Where do we stand on vascular calcification?

Hematopoiesis in Bovine Heart Bone

Contact Info

Product

Resources

About