Ueber Phagocytose und die Abfuhrwege der Leucocyten in den Lymphdrüsen

Schumacher, S.

doi:10.1007/bf02979033

Cited by 32 publications

(11 citation statements)

References 9 publications

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“…Based on early light microscopical obser vations it was assumed that cells associated with the endothelium of the HEV were often located inside the endothelial cell [2], This was confirmed by Marchesi and Gowans [5] in an electron-microscopical study in which they found that lymphocytes were indeed capable of penetrating the endothelial cell. It has been proposed that via this transcellular pathway the endothelial cells could exert a regulatory influence, in particular on the number of lymphocytes leaving the blood stream [6].…”

Section: Do Lymphocytes Actually Migrate Through or Do They Pass Betwsupporting

confidence: 54%

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The Endothelium of the High Endothelial Venule: A Specialized Endothelium with Unique Properties

Kraal

Duijvestijn

Hendriks³

1987

Pathobiology

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High endothelial venules (HEV) in lymphoid organs are specialized to facilitate the passage of lymphocytes into lymphoid parenchyma. This is accomplished by a ligand-receptor system on the endothelium and lymphocytes, which differs between lymph nodes and Peyer’s patch. Experiments discussed in this paper show that other non-HEV-derived endothelial cells can acquire the characteristics of HEV and that HEV may differentiate under influences from their local microenvironments.

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Section: Do Lymphocytes Actually Migrate Through or Do They Pass Betwsupporting

confidence: 54%

“…Associated with the wall of these venules, a large number of lymphocytes can always be observed, suggestive for a role of the HEV in lymphocyte migration [1][2][3].…”

mentioning

confidence: 99%

The Endothelium of the High Endothelial Venule: A Specialized Endothelium with Unique Properties

Kraal

Duijvestijn

Hendriks³

1987

Pathobiology

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“…The question then arises as to whether these endothelial cells receive the stimulus for plasmocytic differentiation while lining the venules or after penetration in the nodes' parenchyma. Our answer is based on the fact that these cells are continuously crossed by small lymphocytes (Renaut, 1881;Schumacher, 1899) for which Gowans et al ('62) presented evidence of playing a role in the initiation of the immune response. Although other possibilities are conceivable, we suggest that these lymphocytes are the "carriers" bringing the stimulus to the endothelial cells lining the venules.…”

Section: H E M O C Y T O B L a S Tmentioning

confidence: 99%

Cytokinetics of antibody formation

Sainte-Marie

1966

J. Cell. Physiol.

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The mediastinal nodes of untreated rats contain medullary cords populated by variously matured plasmocytes, classified into large, medium, and small on the basis of nuclear diameters. Since hemocytopoietic cells proliferate while maturing and since proliferation yields progressively greater numbers of mitoses, it follows that the order of mitotic increment of the variously matured plasmocytes can tell the position of each type in the plasmocytic series. Counts were carried out in 32 rats killed at four successive 6-hour intervals. For 3000 plasmocytes counted per rat, there was an average of 10, 26, and 34 mitoses of large, medium, and small plasmocytes respectively. On the basis of an equal mitotic duration for all plasmocytes, this indicated that the large plasmocytes yield the medium plasmocytes which, in turn, give rise to the small plasmocytes. The number of generations of each type of plasmocyte was determined by comparing the experimental ratios, for number of mitoses of a progeny type of plasmocyte over that of its progenitor type, with similar theoretical ratios expected for variable numbers of generations of progeny and progenitor cells. Comparisons indicated that there are likely four generations of large plasmocytes followed by two of medium plasmocytes and also two of small plasmocytes. As for the nature of the ultimate precursors of the large plasmocytes, it is postulated that they are the hypertrophied endothelial cells of the nodes' postcapillary venules. These cells would receive the appropriate stimulus for plasmocytic differentiation from the small lymphocytes which cross them to enter these venules. Present termsCurrent Nuclear terms diameters ~~ P

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“…The occurrence of lymphocytes within their walls led investigators to conclude that these vessels were important in the transfer of cells from blood to tissue (Schumacher, 1899;Hummel, 1935). selectively migrate from blood vessels to lymph nodes at this site (Gowans & Knight, 1964).…”

mentioning

confidence: 99%