Ueber Terpentinöl, Leinöl und Leinölfirnis, ihre Surrogate und Verfälschungen

Platinum−Nitrogen Bond Rearrangements in Isomeric cis‐PtII(NH3)2‐bis(9‐methyladenine) Complexes under Alkaline Conditions

“…This is quite interesting when considering that for the two major DNA adducts of cisplatin, that is, A‐N(7),G‐N(7) and G‐N(7),G‐N(7) (where A = adenine, G = guanine), the former is more mutagenic than the latter, which is cytotoxic 1,34,35. In addition, in dicationic 3 and 4 , the N(6)‐bound 9‐made exists in the rare imino tautomer with the N(1) site bearing a proton in an analogous fashion to other N(6)‐metalated adenine derivatives 4,10,11.…”

“…The discovery of the anticarcinogenic activity of cis ‐[PtCl 2 (NH 3 ) 2 ] (cisplatin) by B. Rosenberg in 1969 has led to research interests being focused on the interactions of Pt compounds with nucleic acids and their constituents 1−3. From a chemical point of view, considerable effort has been paid to the various binding modes4 of Pt and to the kinetics of complexation 1,5,6. Due to the general inertness of Pt II and Pt IV , and the high thermodynamic stability of the Pt−N bond, the factors affecting the initial binding step of Pt to DNA are considered crucial for understanding the biological activity of Pt drugs1,5 and, in this respect, findings on relatively facile Pt−N bond rearrangements at the oligonucleotide level are of prime interest 7−9.…”