UFT� plus oral leucovorin calcium (Orzel?) and radiation in combined modality therapy: A comprehensive review

Concomitant Chemoradiotherapy Using Carboplatin, Tegafur-Uracil and Leucovorin for Stage III and IV Head-and-Neck Cancer: Results of GORTEC Phase II Study

“…This is a real program of concurrent chemoradiotherapy. UFT has shown its effectiveness in combination with radiotherapy in many tumor locations, particularly colorectal cancer (34).…”

Concurrent chemoradiotherapy with carboplatin and uracil-f tegafur (UFT) for patients with poor performance status with locally advanced squamous cell carcinoma of the head and neck (SCCHN)

“…In SCCHN, it has been shown that efficacy is equivalent and yet toxicity is less with carboplatin [6 Á8]. UFT was the first oral DPD inhibitory fluoropyrimidine to be developed [11]. Continuous oral administration of UFT instead of intravenous 5-FU infusion may be useful for reducing toxicity and increasing the anti-tumor effect [11].…”

“…Carboplatin was found to be active in SCCHN and to have radiation-sensitizing properties similar to cisplatin, but with less nephrotoxicity [9,10]. UFT was the first oral dihydropyrimidine dehydrogen (DPD) inhibitory fluoropyrimidine to be developed [11]. Continuous oral administration of UFT, instead of intravenous 5-FU infusion, may be useful for reducing toxicity and increasing the anti-tumor effect [11].…”

High-dose radiotherapy and concurrent UFT plus l-leucovorin in locally advanced rectal cancer: A phase I trial

“…In recent years, a number of phase I and II trials have indicated that resection is possible in more than 50% of the patients receiving combined treatment, and approximately 10% will have complete pathological remission [13]. The chemotherapy has been based on 5-fluorouracil (5-FU) as the drug of choice.…”

“…There are indications that continuous infusion is more effective than bolus 5-FU [14], but continuous infusion is complicated by the use of central venous catheter and portable infusion pumps causing problems such as venous thrombosis and infection. However, similar serum and tumour concentrations of 5-FU can be obtained by oral therapy [13,15].…”