UHPLC-PDA-ESI-TOF/MS metabolic profiling of Arctostaphylos pungens and Arctostaphylos uva-ursi. A comparative study of phenolic compounds from leaf methanolic extracts

Panusa, Alessia; Petrucci, Rita; Marrosu, Giancarlo; Multari, Giuseppina; Gallo, Francesca Romana

doi:10.1016/j.phytochem.2015.01.002

Cited by 46 publications

(50 citation statements)

References 33 publications

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“…Some of the peaks at higher m/z have been assigned to glycosides which aglycones are eluted in the second region of the chromatogram. This elution order is consistent with the RTs already observed for flavonoids and their glycosides (Panusa, Petrucci, Marrosu, Multari, & Gallo, 2015).…”

Section: Furokauranessupporting

confidence: 91%

UHPLC-PDA-ESI-TOF/MS metabolic profiling and antioxidant capacity of arabica and robusta coffee silverskin: Antioxidants vs phytotoxins

Panusa

Petrucci

Lavecchia

et al. 2017

Food Research International

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A deeper knowledge of the chemical composition of coffee silverskin (CS) is needed due to the growing interest in its use as a food additive or an ingredient of dietary supplements. Accordingly, the aim of this paper was to investigate the metabolic profile of aqueous extracts of two varieties of CS, Coffee arabica (CS-A), Coffee canephora var. robusta (CS-R) and of a blend of the two (CS-b) and to compare it to the profile of Coffee arabica green coffee (GC). Chlorogenic acids, caffeine, furokauranes, and atractyligenins, phytotoxins not previously detected in CS, were either identified or tentatively assigned. An unknown compound, presumably a carboxyatractyligenin glycoside was detected only in GC. Caffeine and chlorogenic acids were quantified while the content of furokauranes and atractyligens was estimated. GC and CS were also characterized in terms of total polyphenols and antioxidant capacity. Differences in the metabolites distribution, polyphenols and antioxidant capacity in GC and CS were detailed.

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Section: Furokauranessupporting

confidence: 91%

UHPLC-PDA-ESI-TOF/MS metabolic profiling and antioxidant capacity of arabica and robusta coffee silverskin: Antioxidants vs phytotoxins

Panusa

Petrucci

Lavecchia

et al. 2017

Food Research International

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“…The chemical composition of bearberry leaves was also investigated by Panusa et al [53]. The chemical composition determined by them was in agreement with the results obtained by Saleem et al [51] and Olennikov and Chekhirova [52].…”

Section: Phenolic Compounds Present In Vaccinium Species Leavessupporting

confidence: 82%

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

et al. 2019

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Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. Furthermore, the importance of bioaccessibility and bioavailability of the phenolic compounds have been summarized. The findings highlight the fact that leaves of some Ericaceae species deserve increased attention and should be studied more profoundly for their biological activities, especially those from spontaneous flora.

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“…To the best of our knowledge, chloramphenicol and denatonium benzoate are unlikely to be present in bat diets. By contrast, arbutin and salicin are naturally occurring glycosides, both of which are secondary metabolites in the leaves of plants (Panusa, Petrucci, Marrosu, Multari, & Gallo, ). Previous studies showed that herbivorous insects have the ability to synthesize or sequester glucosides for defending against their predators, such as insect‐eating bats (Kuhn et al., ; Nishida, ; Opitz & Muller, ; Zagrobelny et al., ).…”

Section: Discussionmentioning

confidence: 99%

Lineage‐specific duplication and adaptive evolution of bitter taste receptor genes in bats

Jiao

Wang

Zhang³

et al. 2018

Molecular Ecology

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By generating raw genetic material and diverse biological functions, gene duplication represents a major evolutionary mechanism that is of fundamental importance in ecological adaptation. The lineage-specific duplication events of bitter taste receptor genes (Tas2rs) have been identified in a number of vertebrates, but functional evolution of new Tas2r copies after duplication remains largely unknown. Here, we present the largest data set of bat Tas2rs to date, identified from existing genome sequences of 15 bat species and newly sequenced from 17 bat species, and demonstrate lineage-specific duplications of Tas2r16, Tas2r18 and Tas2r41 that only occurred in Myotis bats. Myotis bats are highly speciose and represent the only mammalian genus that is naturally distributed on every continent except Antarctica. The occupation of such diverse habitats might have driven the Tas2r gene expansion. New copies of Tas2rs in Myotis bats have shown molecular adaptation and functional divergence. For example, three copies of Tas2r16 in Myotis davidii showed differential sensitivities to arbutin and salicin that may occur in their insect prey, as suggested by cell-based functional assays. We hypothesize that functional differences among Tas2r copies in Myotis bats would increase their survival rate through preventing the ingestion of an elevated number of bitter-tasting dietary toxins from their insect prey, which may have facilitated their adaptation to diverse habitats. Our study demonstrates functional changes of new Tas2r copies after lineage-specific duplications in Myotis bats and highlights the potential role of taste perception in exploiting new environments.

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UHPLC-PDA-ESI-TOF/MS metabolic profiling of Arctostaphylos pungens and Arctostaphylos uva-ursi. A comparative study of phenolic compounds from leaf methanolic extracts

Cited by 46 publications

References 33 publications

UHPLC-PDA-ESI-TOF/MS metabolic profiling and antioxidant capacity of arabica and robusta coffee silverskin: Antioxidants vs phytotoxins

UHPLC-PDA-ESI-TOF/MS metabolic profiling and antioxidant capacity of arabica and robusta coffee silverskin: Antioxidants vs phytotoxins

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

Lineage‐specific duplication and adaptive evolution of bitter taste receptor genes in bats

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