UiO-66 metal-organic framework as a double actor in chitosan scaffolds: Antibiotic carrier and osteogenesis promoter

Karakeçili, Ayşe; Topuz, Berna; Ersoy, Feriha Şevval; Şahin, Toygun; Gunyakti, Ayse; Demirtaş, Tuǧrul Tolga

doi:10.1016/j.bioadv.2022.212757

Cited by 31 publications

(13 citation statements)

References 40 publications

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“…The CS scaffolds were biocompatible with MC3T3-E1 pre-osteoblast, up-regulated the osteogenesis-related gene expression, and boosted the extracellular matrix mineralization. 215 6. Future prospects CS/MOFs offer outstanding physical and chemical properties, which are mandatory for various applications.…”

Section: Medical Applications Of Cs/mofmentioning

confidence: 99%

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Chitosan/metal organic frameworks for environmental, energy, and bio-medical applications: a review

Balakrishnan,

Jacob,

Dayanandan

et al. 2023

Mater. Adv.

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Section: Medical Applications Of Cs/mofmentioning

confidence: 99%

“…The CS scaffolds were biocompatible with MC3T3-E1 pre-osteoblast, up-regulated the osteogenesis-related gene expression, and boosted the extracellular matrix mineralization. 215…”

Section: Applications Of Cs Mofsmentioning

confidence: 99%

Chitosan/metal organic frameworks for environmental, energy, and bio-medical applications: a review

Balakrishnan,

Jacob,

Dayanandan

et al. 2023

Mater. Adv.

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“…Surface modifications of MOF particles, such as the introduction of cell‐adhesive peptides or bioactive coatings, can enhance cell–material interactions and promote osteoblast adhesion, spreading, and osteogenic activity. [ 80 ] These tailored MOF surfaces offer a favorable microenvironment for cell attachment and subsequent osteoblast proliferation and mineralization. [ 81 ] For instance, Liu et al.…”

Section: Applications Of Mof‐integrated Composites In Btementioning

confidence: 99%

Metal–Organic Framework‐Integrated Composites for Bone Tissue Regeneration

Mi,

Xiong,

Zhao

et al. 2023

Adv Funct Materials

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Metal–organic frameworks (MOFs) exhibit exceptional characteristics, including high porosity and adjustable properties, rendering them highly suitable for biomedical applications. Recently, researchers have directed their attention toward the integration of MOFs into composites for bone tissue regeneration (BTE), presenting distinct advantages over conventional substitutes. In this comprehensive review, the authors delve into the latest advancements concerning MOF‐integrated composites for BTE. This exploration encompasses an examination of the properties of MOFs and the various synthesis techniques employed to fabricate these materials. Furthermore, the diverse applications of MOF‐integrated composites in BTE are investigated, encompassing areas such as antibacterial properties, osteogenic differentiation, angiogenesis, and immunomodulation. By providing a comprehensive overview of the ongoing research on MOF‐integrated composites for BTE, this study holds the promise of yielding innovative solutions within the realm of orthopedics.

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“…UiO-66 nanocrystals were proved to possess a twofer character that would enrich their use in the biomedical field. 23 Our aforementioned study has been the starting point of the present study, and herein two different synthesis approaches to design fosfomycin incorporated UiO-66 MOF structures and DFT simulations to predict the fosfomycin-UiO-66 interaction have been explored. Room temperature synthesis could be advantageous for the in situ encapsulation of fosfomycin during the UiO-66 crystallization process and thus, a solution-based method of antibiotic encapsulated UiO-66 with retained activity has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…UiO-66 nanocrystals were proved to possess a twofer character that would enrich their use in the biomedical field. 23…”

Section: Introductionmentioning

confidence: 99%

Design of a Zr-based metal–organic framework as an efficient fosfomycin carrier: a combined experimental and DFT study

et al. 2023

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UiO-66 metal-organic framework as a double actor in chitosan scaffolds: Antibiotic carrier and osteogenesis promoter

Cited by 31 publications

References 40 publications

Chitosan/metal organic frameworks for environmental, energy, and bio-medical applications: a review

Chitosan/metal organic frameworks for environmental, energy, and bio-medical applications: a review

Metal–Organic Framework‐Integrated Composites for Bone Tissue Regeneration

Design of a Zr-based metal–organic framework as an efficient fosfomycin carrier: a combined experimental and DFT study

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