UJI AKTIVITAS ANTIINFLAMASI SENYAWA DALAM MINYAK ATSIRI RIMPANG BANGLE (Zingiber purpureum Roxb) SECARA IN SILICO

Abstract

Inflammation is a response from the body to injury or infection which is characterized by redness (rubor), increased temperature (calor), swelling (tumor), pain (dolor) and loss of function (functio laesa). The purpose of this study is to find active compounds of Bangle (Zingiber purpureum R) that have the potential to be antiinflammatory using the In Silico approach. The methods used are molecular docking and molecular dynamics.. The screening and molecular docking simulation results showed that the compound phenylmethylene can bind and have a stable interaction with the COX-1 receptor (anti-inflammatory) with binding affinity (ΔG) -6.94 kcal/ mol. This showed that the affinity level of phenylmethylene to COX-1 was predicted to be activity antiinflammatory.