Uji efek antipiretik infusa daun sungkai (Peronema canescens) pada mencit putih jantan (Mus musculus)

Brata, Andy; Wasih, Efriliya Andila

doi:10.30644/rik.v10i2.554

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…After tracing previous research regarding the benefits of sungkai leaves, it was found that sungkai leaves have antipyretic activity (Brata, A. & Wasih, E.A., 2021), and as an antiinflammatory (Rahman, U., 2021).…”

Section: Introductionmentioning

confidence: 93%

ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID

Wahyuni,

Muin,

Defirson

et al. 2023

JFSP

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Traditional medicine, which is generally considered safer than modern medicine, makes people choose alternative treatments using medicinal plants, one of which is to treat pain. One of the medicinal plants used to treat pain is a plant that contains flavonoids, one of which is the Sungkai plant (Penorema canescens Jack). The research design used was The Static Group Comparison, where the test animals used were divided into 5 groups, each group consisting of 5 mice. Group 1 was given 1 percent of CMC. Group II was given ethanol extract of Sungkai leaves at a dose of 300 mg/Kg BW. Group III was given EEDS at a dose of 600 mg/kg BW. Group IV was given EEDS at a dose of 900 mg/Kg BW. Group V was given paracetamol suspension. The results showed that there was an analgesic activity in the EEDS group, dose I was 50 percentage, dose II was 55,798 percentage, and dose III was 69,564 percentage. The study concluded that statisti-cally there was no significant difference in analgesic activity in white male mice between the EEDS doses I, II, and III groups and the paracetamol group.

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Section: Introductionmentioning

confidence: 93%

ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID

Wahyuni,

Muin,

Defirson

et al. 2023

JFSP

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“…Mencit diinfeksikan Plasmodium berghei dengan menginjeksikan inokulum sebanyak 0,2 cc secara intra-peritoneal. 8 Kelompok perlakuan antiplasmodium dan immunostimulant diberikan dosis 100 mg/KgBB. Kelompok kontrol antiplasmodium dan immunostimulant hanya diberikan larutan RPMI hanya 0,2 ml.…”

Section: Persiapan Hewan Ujiunclassified

Uji Efektivitasan Buah Momordica Charantia L Sebagai Imunostimulan Dan Antiplasmodium Terhadap Infeksi Parasit Plasmodium Berghei Pada Mencit

Semara,

Sri Laksemi,

Sri Laksemi

et al. 2023

eum

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ABSTRAK Malaria adalah penyakit infeksi parasit Plasmodium sp. Plasmodium merupakan parasit yang menyerang sel darah merah dan dapat menimbulkan obstruksi pada kapiler organ tubuh yang vital. Kasus resisten plasmodium terhadap obat anti malaria membuat banyak penelitian yang mencoba mencari obat alternatif dari tumbuhan yang mudah diperoleh masyarakat, salah satu tanaman yang memiliki potensi yakni Momordica charantia L atau yang dikenal buah pare. Untuk mengetahui pengaruh ekstrak buah pare (Momordica charantia L) dengan dosis 100 mg/kgBB untuk antiplasmodium dan 100 mg/kgBB untuk immunostimulant terhadap derajat parsitemia pada mencit Balb/c yang diinfeksikan Plasmodium Berghei. Penelitian ini merupakan penelitian eksperimental secara In Vivo dengan menggunakan rancangan metode Randomized Post test Only Controlled Group menggunakan 24 sampel mencit yang dibagi menjadi empat kelompok yakni satu kelompok kontrol negatif antiplasmodium, satu kelompok negatif immunostimulant, satu kelompok perlakuan antiplasmodium dan satu kelompok perlakuan immunostimulant. Didapatkan hasil rerata derajat parasitemia pada kelompok kontrol negatif antiplasmodium 34.9 %, kelompok kontrol negatif immunostimulant 33.9 %, kelompok perlakuan antiplasmodium dosis 100 mg/kgBB sebesar 19.8 % dan kelompok perlakuan immunostimulant dosis 100 mg/kgBB sebesar 17.1 %. Berdasarkan hasil analisis One Way Anova ditemukan perbedaan rerata antara masing-masing kelompok kontrol dan kelompok perlakuan yakni kelompok antiplasmodium dengan nilai p value <0.001 dan kelompok immunostimulant dengan nilai p value <0.002. Hasil penelitian menunjukan ekstrak buah pare (Momordica charantia L) dapat menghambat pertumbuhan parasit Plasmodium Berghei dengan melihat perbedaan rerata masing-masing kelompok kontrol dan kelompok perlakuan, dengan masing-masing dosis kelompok yakni 100 mg/kbBB. Kata kunci: Antimalaria, Momordica charantia L, Plasmodium Berghei, Derajat Parasitemia

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“…Al-Kimia|Volume 10 Nomor 2 2022. 193 (Brata and Wasih 2021), antidiabetic (Aini 2022), and immunostimulatory (Sistiany 2022). However, these studies only focus on utilizing sungkai leaves as extract preparations.…”

Section: Antipyreticmentioning

confidence: 99%

Formulation and Characterization of Sungkai Leaf Extract Nanoemulsion

et al. 2022

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Sungkai (Peronema canescens Jack) leaves are empirically used for various treatments, and their efficacy can be enhanced using nanoparticle technology, especially nanoemulsions. The purpose was to find the best nanoemulsion formula (NES) containing sungkai leaf extract (EDS). Sungkai leaves were extracted with 70% ethanol, and the compounds were determined by liquid chromatography-mass spectrometry. NES was formed by mixing EDS (260, 400, and 530 mg), VCO, tween80, PEG400, soy lecithin, sodium alginate, and deionized water. The NES formed were characterized by particle size, polydispersity index (PDI), zeta potential, pH, viscosity, percent transmittance, and physical stability test. The results showed that EDS contains at least seven compounds, with eupatilin as a dominant compound. The characterization results obtained NES with a particle size range of 270–520 nm with a PDI value of 0.413–0.608. NES was categorized as stable with a zeta potential value of -45.9 to -48.7 mV and no phase separation based on the centrifugation test. NES has a viscosity of about 1.90–2.03 cP, pH 7, and a percent transmittance of 93–98%. The best formula is the formula with EDS F1 (260 mg). Thus, NES has the potential for the development of multiple treatment targets.

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Uji efek antipiretik infusa daun sungkai (Peronema canescens) pada mencit putih jantan (Mus musculus)

Cited by 6 publications

References 2 publications

ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID

ANALGETIC ACTIVITY TEST OF ETHANOL EXTRACT SUNGKAI LEAF (Peronema canescens Jack) IN WHITE MALE MOUSE (Mus musculus) INDUCED WITH ACETIC ACID

Uji Efektivitasan Buah Momordica Charantia L Sebagai Imunostimulan Dan Antiplasmodium Terhadap Infeksi Parasit Plasmodium Berghei Pada Mencit

Formulation and Characterization of Sungkai Leaf Extract Nanoemulsion

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