UJI MUTU FISIK SEDIAAN KRIM EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI NA. LAURIL SULFAT

Arisanty, Arisanty; Anita, Anita

doi:10.32382/mf.v14i1.80

Cited by 4 publications

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“…Obat akan berpenetrasi ke dalam kulit apabila gel menempel dengan baik (Dwiastuti & Ardiyati, 2020). Sediaan gel dikatakan baik jika memenuhi persyaratan mutu fisik yang ditetapkan dalam buku resmi atau Farmakope Indonesia, seperti organoleptis, homogenitas, pH, dan daya sebar (Arisanty & Anita, 2016). Sediaan gel pada penelitian ini telah memenuhi persyaratan uji tersebut.…”

Section: Evaluasi Sediaan Gelunclassified

Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus)

Milasanti,

Widara,

Fitri

2023

jharma

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Aloe vera (Aloe vera L.) is an herbal plant that contains phytochemicals such as tannins, saponins, flavonoids, and polyphenols, which are useful in healing cut wounds. The phytochemical content has antimicrobial, antibacterial, and antiseptic properties. Several research findings show wound healing activity in experimental animals that have been treated with aloe vera plant extract. This research aimed to make ethanol extract gel from aloe vera leaves and test cuts on male white mice (Mus musculus). The type of research used is true experimental design research. An incision wound was made on the back of the mouse with a length of 1 cm and a depth of 2 mm. The test animals used were 24 animals which were divided into 6 experimental groups, namely Positive Control (Bioplacenton), Negative Control (Without extract content), Base (Without aloe vera extract and preservatives), F1 (Aloe vera extract content 2.5%), F2 (Aloe vera extract content 5%), and F3 (Aloe vera extract content 7.5%). Statistical analysis of wound healing data was carried out using the One way ANOVA (Analysis of Variants) method, while the physical examination of the gel formulation was described descriptively. The statistical test results significantly affected wound healing in male white mice (p<0.05). There is a significant difference between the negative control and F3, p-value = 0.027. The best activity in the wound healing process is F3, with an average percentage of wound healing on the 7th day, F2 on the 8th day, and F1 on the 9th day.

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Section: Evaluasi Sediaan Gelunclassified

Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus)

Milasanti,

Widara,

Fitri

2023

jharma

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“…Penelitian ini didukung dengan penelitian (Sarwanda et al, 2021), mengenai sediaan lip balm minyak almond dan ekstrak biji kesumbang keling dimana sediaan tidak ditemukan butiran kasar dan dikatakan homogen. Sediaan yang tidak homogen atau terdapat butiran kasar akan menimbulkan iritasi saat diaplikasikan pada kulit (Arisanty & Anita, 2018).…”

Section: Uji Homogenitasunclassified

Evaluasi mutu fisik sediaan lip balm kombinasi ekstrak kayu secang (Caesalpinia sappan L.) dan madu (Mel depuratum)

Salsabila

Dewi

Atikah

2022

bphr

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Senyawa brazilin pada kayu secang memiliki aktivitas sebagai antioksidan. Madu memiliki khasiat untuk membantu meregenerasi kulit dan membantu mencerahkan warna bibir yang gelap. Kedua bahan tersebut dapat dimanfaatkan sebagai sediaan lip balm untuk menutrisi bibir. Jenis penelitian adalah observasi dengan rancangan penelitian deskriptif. Tujuan dari penelitian ini adalah untuk mengetahui mutu fisik sediaan lip balm kombinasi ekstrak kayu secang (Caesalpinia sappan L.) dan madu (Mel depuratum). Evaluasi mutu fisik meliputi uji organoleptik, homogenitas, pH, daya sebar dan daya lekat. Hasil penelitian menunjukkan bahwa hasil uji organoleptik berupa warna coklat muda, berbau khas oleum cacao. Hasil uji homogen dimana tidak ditemukan butiran kasar. Hasil pengujian pH dan daya lekat sediaan secara berurutan sebesar 6,8 dan 9,7 detik. Nilai rata - rata daya sebar sediaan dengan perlakuan tanpa beban, beban 50 gram, 100 gram, 150 gram dan 200 gram secara berurutan didapatkan sebesar 2,9 cm, 3,2 cm, 3,3 cm, 3,4 cm dan 3,5 cm. Kesimpulan dari penelitian ini adalah evaluasi mutu fisik lip balm meliputi uji organoleptik, uji homogenitas, uji pH dan uji lekat telah memenuhi syarat sediaan lip balm yang baik, kecuali daya sebar belum memenuhi syarat sediaan lip balm yang baik.

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“…Lauryl sulfate 1%, and in testing the pH of the three Na. lauryl sulfate formulas 0.5%, 1%, and 2% do not meet the requirements (Arisanty & Anita, 2018).…”

Section: Introductionmentioning

confidence: 99%

Dosage Evaluation and Antioxidant Activity Test of Lotion of Ethanol Extract of Belimbing Wuluh Leaf (Averrhoa Bilimbi L.)

Ernoviya,

Afriadi

2024

Contagion

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<div><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td align="left" valign="top"><p><em>This study aims to make and evaluate the lotion formula from ethanol extract of star fruit leaves (Averrhoa bilimbi L.) and test the antioxidant activity of the lotion. The research method used is experimental, making lotions and testing antioxidant activity from July to October 2023 at the Semi-Solid Preparation Technology Laboratory, Department of Pharmacy, Poltekkes Kemenkes Medan, and Research Laboratory, University of North Sumatra. In the preparation stage, star fruit leaf simplisia was extracted by maceration using a 95% ethanol solvent. The lotion formula was made with ingredients such as PEG 4000, stearyl alcohol, glycerin, sodium lauryl sulfate, coconut oil, nipagin, and distillate water, with varying concentrations of ethanol extract of star fruit leaves. The formulation was evaluated through organoleptic, homogeneity, pH, spreadability, and viscosity tests. The results showed that the lotion produced had a homogeneous shape and aroma to the concentration of ethanol extract. In addition, the pH of the lotion is also within the safe range for human skin. The spreadability test showed the lotion's ability to spread on the skin, which met the requirements for lotions with spreadability values between 5 and 7 cm. The viscosity of the lotion was also by the set standards. Stability tests were conducted to monitor the physical and chemical changes of the lotion over four weeks. The results showed that lotions with 1% and 3% ethanol extract concentrations were stable during the study period. However, the 5% concentration experienced inhomogeneity changes in the third week. In conclusion, lotion with ethanol extract of star fruit leaves at 1% and 3% concentration can produce a good and stable formula. However, the antioxidant activity of the lotion is still in the weak to moderate category. This research contributes to developing plant-based natural cosmetic products for skin care.</em><em></em></p><p><em> </em></p></td></tr></tbody></table></div><p><strong><em>Keywords: Antioxidant Activity, Belimbing Wuluh, Ethanol Extract, Evaluation, Lotion</em></strong></p>

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UJI MUTU FISIK SEDIAAN KRIM EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI NA. LAURIL SULFAT

Cited by 4 publications

References 0 publications

Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus)

Uji Aktivitas Penyembuhan Luka Sayat Gel Ekstrak Etanol Lidah Buaya (Aloe Vera L.) pada Mencit Putih Jantan (Mus Musculus)

Evaluasi mutu fisik sediaan lip balm kombinasi ekstrak kayu secang (Caesalpinia sappan L.) dan madu (Mel depuratum)

Dosage Evaluation and Antioxidant Activity Test of Lotion of Ethanol Extract of Belimbing Wuluh Leaf (Averrhoa Bilimbi L.)

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