UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Noad, Rob; Simpson, Karl; Fooks, Anthony R.; Hewson, Roger; Gilbert, Sarah C.; Stevens, Mark P.; Hosie, Margaret J.; Prior, Joann L.; Kinsey, Anna; Entrican, Gary; Simpson, Andrew J. H.; Whitty, Christopher J. M.; Carroll, Miles W.

doi:10.1016/j.vaccine.2019.09.009

Cited by 25 publications

(17 citation statements)

References 46 publications

(60 reference statements)

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“…These processes are of particular relevance to coronaviruses as their ability to undergo genetic recombination combined with a relatively high mutation rate facilitates their rapid adaptation to new ecological and host niches [98,99]. This is illustrated by the recent identification of a SARS-CoV-2 variant originating in farmed mink with subsequent detection in the local human population [100], although the epidemiological implications of this phenomenon are as yet unclear.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Risks of SARS-CoV-2 in Wildlife

Delahay¹,

Fuente²,

Smith³

et al. 2021

Preprint

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The novel coronavirus SARS-CoV-2 likely emerged from a wildlife source with transmission to humans followed by rapid geographic spread throughout the globe and severe impacts on both human health and the global economy. Since the onset of the pandemic, there have been many instances of human-to-animal transmission involving companion, farmed and zoo animals, and limited evidence for spread into free-living wildlife. The establishment of reservoirs of infection in wild animals would create significant challenges to infection control in humans and could pose a threat to the welfare and conservation status of wildlife. We discuss the potential for exposure, onward transmission and persistence of SARS-CoV-2 in an initial selection of wild mammals (bats, canids, felids, mustelids, great apes, rodents and cervids). Dynamic risk assessment and targeted surveillance are important tools for the early detection of infection in wildlife, and here we describe a framework for collating and synthesising emerging information to inform targeted surveillance for SARS-CoV-2 in wildlife. Surveillance efforts should be integrated with information from public and veterinary health initiatives to provide insights into the potential role of wild mammals in the epidemiology of SARS-CoV-2.

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Section: Discussionmentioning

confidence: 99%

Assessing the Risks of SARS-CoV-2 in Wildlife

Delahay¹,

Fuente²,

Smith³

et al. 2021

Preprint

Self Cite

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“…This should include integrated programmes of targeted surveillance and the dynamic assessment of risks to animal and human health. Importantly, this need extends beyond the current pandemic, and speaks to the wider requirement for a proactive approach to assessing the dangers of diseases emerging from wildlife [8] and the implications for vaccine pipelines [99]. Hence we reiterate the call by Olival et al [56] for the development of an adaptive framework for surveillance and risk assessment of other coronaviruses in wildlife, domestic animals and human populations at high risk of exposure, so that in the future we may be better prepared to prevent and control their potential impacts on human and animal health.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Risks of SARS-CoV-2 in Wildlife

Delahay¹,

Fuente²,

Smith³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

The novel coronavirus SARS-CoV-2 likely emerged from a wildlife source with transmission to humans followed by rapid geographic spread throughout the globe and dramatic impacts on both human health and global economies. Since the onset of the pandemic, there have been several instances of human-to-animal transmission involving companion, farmed and zoo animals, with the clear potential for spread into free-living wildlife. The establishment of reservoirs of infection in wild animals would create significant challenges to infection control in humans and could pose a threat to the welfare and conservation status of wildlife. Herein, we discuss the potential for exposure, maintenance and onward transmission of SARS-CoV-2 in an initial selection of wild and feral species (bats, canids, felids, mustelids, great apes). Targeted surveillance and dynamic risk assessment are important tools for the early detection of infection in wildlife and a means of collating and synthesising emerging information in a rapidly changing situation. Such efforts should be integrated with public health information to provide insights into the potential role of wild mammals in the continuing epidemiology of SARS-CoV-2. This approach should also be adopted to address the wider need to proactively assess threats to human and animal health from other diseases that may emerge from wildlife.

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“…The development of tools that systematically identify knowledge and capability gaps are beneficial to both researchers and funders alike as they support the co‐ordinated prioritization of research funding. This approach is exemplified by the United Kingdom Department of Health and Social Care (DHSC) Vaccine Network (UKVN) which has adopted a systematic approach to prioritize vaccinology research into animal pathogens with human epidemic potential (Noad et al., 2019). The approach took into account the stage of vaccine development for each pathogen which could then be mapped to a pipeline using an interactive tool that identifies bottlenecks in vaccine development with a focus on the TPP.…”

Section: Discussionmentioning

confidence: 99%

Construction of generic roadmaps for the strategic coordination of global research into infectious diseases of animals and zoonoses

Entrican

Charlier²,

Dalton

et al. 2020

Transbound Emerg Dis

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The Strategic Alliance for Research into Infectious Diseases of Animals and Zoonoses (STAR‐IDAZ) International Research Consortium (IRC) coordinates global animal health research to accelerate delivery of disease control tools and strategies. With this vision, STAR‐IDAZ IRC has constructed four generic research roadmaps for the development of candidate vaccines, diagnostic tests, therapeutics and control strategies for animal diseases. The roadmaps for vaccines, diagnostic tests and therapeutics lead towards a desired target product profile (TPP). These interactive roadmaps describe the building blocks and for each the key research questions, dependencies, challenges and possible solution routes to identify the basic research needed for translation to the TPP. The control strategies roadmap encompasses the vaccine, diagnostic tests, and therapeutic roadmaps within a wider framework focusing on the inter‐dependence of multiple tools and knowledge to control diseases for the benefit of animal and human health. The roadmaps are now being completed for specific diseases and complemented by state‐of‐the‐art information on relevant projects and publications to ensure that the necessary research gaps are addressed for selected priority diseases.

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UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Cited by 25 publications

References 46 publications

Assessing the Risks of SARS-CoV-2 in Wildlife

Assessing the Risks of SARS-CoV-2 in Wildlife

Assessing the Risks of SARS-CoV-2 in Wildlife

Construction of generic roadmaps for the strategic coordination of global research into infectious diseases of animals and zoonoses

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