2016
DOI: 10.17305/bjbms.2016.875
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Ukrain (NSC 631570) ameliorates intestinal ischemia-reperfusion-induced acute lung injury by reducing oxidative stress

Abstract: Intestinal ischemia-reperfusion (I/R) causes severe destruction in remote organs. Lung damage is a frequently seen complication after intestinal I/R. Ukrain (NSC 631570) is a synthetic thiophosphate derivative of alkaloids from the extract of the celandine (Chelidonium majus L.) plant. We investigated the effect of Ukrain in animals with lung injury induced by intestinal I/R. Adult male Spraque-Dawley rats were randomly divided into four groups: control, Ukrain, I/R, I/R with Ukrain. Before intestinal I/R was … Show more

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Cited by 3 publications
(4 citation statements)
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“… Compounds Structure In vitro/in vivo Model (effective dose) Cells (effective concentration) Related pharmacological indicators Related molecular mechanisms Refs. Berberine 40 LPS/Cigarette smoke (10 mg/kg) 16HBE (10 μM) MPO↓ TNF-α↓ IL-6↓ IL8↓ KC↓ MIP-2↓ cPLA-2↓ MCP-1↓ Regulation of PERK‐mediated Nrf2/HO‐1 signaling pathway Inhibition of NF-κB signaling pathway [ [191] , [192] , [193] ] Tetrahydroberberrubine 41 LPS (10 mg/kg) THP-1 (10 μM) TNF-α↓ NO↓ Inactivation of MAPK, AKT and NF-κB signaling pathways [ 194 ] Cavidine 42 LPS (3 mg/kg) A549 (10 μg/mL) TNF-α↓ IL-6↓ Inhibition of NF-κB signaling pathway [ 195 ] Corynoline 43 LPS (15 mg/kg) MPO↓ TNF-α↓ IL-1β↓ IL-6↓ Up-regulation of Nrf2 signaling pathway Inactivation of NF-κB signaling pathway [ 196 ] Ukrain 44 I/R (70 mg/kg) TAS↓ TOS↓ OSI↓ None [ 197 ] Tetrahydhydrocoptisine 45 LPS (10 mg/kg) MPO↓ TNF-α↓ IL-6↓ Inhibition of NF-κB signaling pathway [ 198 ] Protostemonine 46 LPS (10 mg/kg) RAW264.7/BMDMs (30 μM) MPO↓ TNF-α↓ IL1-β↓ IL-6↓ iNOS↓ NO↓ Inactivation of MAPK and AKT signaling pathway [ 199 , ...…”
Section: Mechanisms Involved In Ali/ardsmentioning
confidence: 99%
See 1 more Smart Citation
“… Compounds Structure In vitro/in vivo Model (effective dose) Cells (effective concentration) Related pharmacological indicators Related molecular mechanisms Refs. Berberine 40 LPS/Cigarette smoke (10 mg/kg) 16HBE (10 μM) MPO↓ TNF-α↓ IL-6↓ IL8↓ KC↓ MIP-2↓ cPLA-2↓ MCP-1↓ Regulation of PERK‐mediated Nrf2/HO‐1 signaling pathway Inhibition of NF-κB signaling pathway [ [191] , [192] , [193] ] Tetrahydroberberrubine 41 LPS (10 mg/kg) THP-1 (10 μM) TNF-α↓ NO↓ Inactivation of MAPK, AKT and NF-κB signaling pathways [ 194 ] Cavidine 42 LPS (3 mg/kg) A549 (10 μg/mL) TNF-α↓ IL-6↓ Inhibition of NF-κB signaling pathway [ 195 ] Corynoline 43 LPS (15 mg/kg) MPO↓ TNF-α↓ IL-1β↓ IL-6↓ Up-regulation of Nrf2 signaling pathway Inactivation of NF-κB signaling pathway [ 196 ] Ukrain 44 I/R (70 mg/kg) TAS↓ TOS↓ OSI↓ None [ 197 ] Tetrahydhydrocoptisine 45 LPS (10 mg/kg) MPO↓ TNF-α↓ IL-6↓ Inhibition of NF-κB signaling pathway [ 198 ] Protostemonine 46 LPS (10 mg/kg) RAW264.7/BMDMs (30 μM) MPO↓ TNF-α↓ IL1-β↓ IL-6↓ iNOS↓ NO↓ Inactivation of MAPK and AKT signaling pathway [ 199 , ...…”
Section: Mechanisms Involved In Ali/ardsmentioning
confidence: 99%
“…Ukrain 44 is an active alkaloid extracted from Chelidonium majus L. This compound was reported to markedly inhibit lung damage and histopathological changes in mice with ALI induced by I/R, which were associated with increasing total anti-oxidant status, as well as decreasing total oxidant status and oxidative stress index levels [ 197 ].…”
Section: Natural Compounds That Exert Anti-ali Effectsmentioning
confidence: 99%
“…It appears in early evolution that oxidative stress commonly associates with either long-term degenerative diseases or acute ischemia–reperfusion injury [ 1 , 2 , 3 , 4 , 5 , 6 ]. The causes for these pathologies are generally inseparable from the shift of reactive oxygen species (ROS) from mediating normal physiological responses (i.e., redox biology) to invoke inevitable cellular dysfunctions through oxidative damage, especially inefficient oxidative phosphorylation in the mitochondria [ 7 ].…”
Section: Introductionmentioning
confidence: 99%
“…CHF is mainly caused by myocardial infarction, hypertension, valvular heart disease, and cardiomyopathy. Furthermore, oxidative stress has been proved to aggravated CHF [5][6][7], and the leading cause of oxidative stress was the imbalance between the production of reactive oxygen species (ROS) and the endogenous antioxidant defense system [8][9][10][11][12]. However, the prevention and existing treatment strategies of oxidative stress in CHF are not effective in improving the survival rate, so further studies are urgently needed.…”
Section: Introductionmentioning
confidence: 99%