In this note, the Ulam stability of a general functional equation in several variables is investigated. It is shown that this equation is Ulam stable in m-Banach spaces. Since a particular case of the considered equation is, among others, a functional equation introduced by Ji et al. and Zhao et al. for a characterization of the so-called multi-quadratic mapping, a result on its stability is also presented. Moreover, some other applications are provided.