Úlceras Aftosas Recorrentes e sua possível associação ao estresse

BACKGROUNDRecurrent aphthous ulcerations are common benign ulcerated lesions on the mouth, whose etiology is poorly understood, with controversial treatment and difficult to control in clinical practice.OBJECTIVETo evaluate the cases of recurrent aphthous ulcerations with a focus on treatment, diagnosis and etiology.METHODSThis is a retrospective study of the cases of the Oral Diagnosis service of the Rio Grande do Norte Federal University in Natal/RN. Data such as sex, age, race, location, smoking habits, types of treatment, relapsing episodes, laboratory test results and clinical characteristics were collected. The associations between the variables were analyzed using the Pearson Chi-square test (p <0.05).RESULTSA total of 4895 patients were seen in the service over a period of 11 years. Of these, 161 (3.3%) had complaints of oral aphthous ulcerations, of which 76 (47.2%) were diagnosed as suffering from recurrent aphthous ulcerations and 68 (42.2%) with clinical information necessary for evaluation. The tongue was the most affected anatomical region, with 27 individuals (39.7%), followed by the buccal mucosa, with 22 cases (32.3%).STUDY LIMITATIONSRetrospective study with data from medical records.CONCLUSIONDental surgeons, dermatologists and otorhinolaryngologists are the main responsible for the first contact with patients with this disease and should be attentive to the clinical aspects and treat each patient in an individualized way, since the therapy is palliative, its diagnosis is by exclusion and its etiology is unknown.

show abstract

“…Despite the name and its features, the herpes simplex virus (HSV) is not identified in these lesions. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Queiroz

Silva

Medeiros

et al. 2018

An. Bras. Dermatol.

View full text Add to dashboard Cite

show abstract

Bixin Action in the Healing Process of Rats Mouth Wounds

Piva¹,

Johann²,

Costa³

et al. 2014

CPB

View full text Add to dashboard Cite

Oral lesions that manifest as ulcer lesions are quite common and can cause discomfort to the patient. Searching for drugs to accelerate the healing of these lesions is nonstop process. Bixin is a molecule found in annatto (urucum) seeds and is considered a viable therapeutic option to treat such lesions due to its anti-inflammatory, anti-oxidant, and healing properties. Therefore, the present study aimed to evaluate the effect of the bixin solution in the ulcer healing process in the oral mucosa of rats. Ulcers were induced with punches of 0.5 cm in the middle of the dorsum of the tongue of 64 Wistar rats. The animals were randomly divided into 8 groups, in which 4 groups were treated with saline solution, while the other 4 were treated with the bixin solution. The animals were sacrificed in the periods 2, 7, 14, and 21 days after the beginning of the treatment. The species were histologically processed and stained with hematoxylin/eosin and picrosirius. Fibroblasts, reepithelialization, and wound contraction could be observed, as could the quantification of neutrophils, macrophages, plasma cells, lymphocytes, and mature and immature collagen. On the seventh day, the experimental group, when compared to the control group, presented a higher proliferation of fibroblasts, more advanced reepithelialization, and a higher contraction in the wounds. A reduction in the average number of neutrophils in the experimental group, when compared to the control group, could be observed in all periods (p=0.000). Up to two days, the total collagen area was higher (p=0.044) in the experimental group (4139.60±3047.51t han in the control group (1564.81±918.47). The deposition of mature collagen, on the 14(th) day, was higher (p=0.048) in the experimental group (5802.40±3578.18) than in the control group (1737.26±1439.97). The results found in the present study indicate that the bixin solution inhibits the acute inflammatory response with a minor average number of neutrophils and accelerates reepithelialization, wound contraction and collagen maturation, thus illustrating that this solution does in fact represent an important adjuvant in the treatment of ulcers.

show abstract

Doença de Sutton: Diagnóstico, manejo e opções terapêuticas

Delamura

Souza

Viotto

et al. 2021

RSD

View full text Add to dashboard Cite

A estomatite aftosa recorrente (EAR) é uma alteração mais comum da mucosa oral e se caracteriza por uma lesão ulcerada, bem definida, dolorosa, com centro necrótico, bordas elevadas e halo eritematoso, levando a um impacto negativo na qualidade de vida dos pacientes. Entretanto, ainda não ocorreu a caracterização de um agente etiológico específico para essa afecção. A EAR possui três formas principais, sendo a EAR menor a mais comum na cavidade bucal, as quais são ulcerações bem definidas, dolorosas e cicatrizam em torno de 10 a 14 dias. A herpetiforme, que possui várias lesões e podem coalescer entre 7 e 10 dias, por fim temos a EAR maior, a qual pode perdurar por mais de 6 semanas e podem deixar cicatrizes. O diagnóstico das lesões é feito após um exame clínico minucioso. Metodologia: Este estudo é um relato de caso de forma qualitativa e descritiva, trazendo dados relevantes da literatura. o ético os princípios da Declaração de Helsinque foram respeitados e o paciente assinou o “Termo de Consentimento Livre e Esclarecido” para participar da pesquisa. O objetivo deste estudo foi relatar um caso de EAR em um paciente do gênero masculino de 41 anos de idade com doença de Sutton, apresentando múltiplas úlceras necrosantes dentro de 9 anos de recidivas. Conclusão: Por ser a etiologia da EAR ainda desconhecida e uma desordem comum e recorrente na cavidade bucal o tratamento atual é diversificado e atenta-se no alívio dos sintomas da doença, variando, desde o uso de produtos naturais, uso tópico, anti-inflamatórios, imunomoduladores e aplicação do laser de baixa potência.

show abstract

Úlceras Aftosas Recorrentes e sua possível associação ao estresse

Cited by 3 publications

References 32 publications

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Recurrent aphthous ulceration: an epidemiological study of etiological factors, treatment and differential diagnosis

Bixin Action in the Healing Process of Rats Mouth Wounds

Doença de Sutton: Diagnóstico, manejo e opções terapêuticas

Contact Info

Product

Resources

About