Ulcerated epithelioid hemangioendothelioma of the foot in childhood

Forschner, Andrea; Harms, D.; Metzler, Gisela; Sönnichsen, Karsten; Ulmer, Anja; Rassner, G.; Fierlbeck, Gerhard

doi:10.1067/mjd.2003.416

Cited by 27 publications

(27 citation statements)

References 27 publications

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“…Although initially thought to represent a low-grade malignancy, EHE has significant metastatic potential with reported rates ranging from 20% to 30%. Primary cutaneous variants are rare and show more indolent behaviour with only one reported case of lymph node metastasis described in the literature 81. EHE characteristically expands the vessel wall, occludes the lumen and spreads into surrounding tissue.…”

Section: Differential Diagnosismentioning

confidence: 99%

Cutaneous angiosarcoma: a current update

et al. 2017

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Cutaneous angiosarcoma (cAS) is a rare malignant neoplasm with variable clinical presentation. Although a distinct vascular tumour, cAS shares many overlapping histopathological features with other vasoformative and epithelioid tumours or 'mimickers'. cAS shows aggressive behaviour and carries a grave prognosis, thus early diagnosis is of paramount importance to achieve the best possible outcomes. Recently, several genetic studies were conducted leading to the identification of novel molecular targets in the treatment of cAS. Herein, we present a comprehensive review of cAS with discussion of its clinical, histopathological and molecular aspects, the differential diagnosis, as well as current therapies including ongoing clinical trials.

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Section: Differential Diagnosismentioning

confidence: 99%

Cutaneous angiosarcoma: a current update

et al. 2017

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“…In the skin, it seems that this neoplasm usually arises from a medium‐sized or large vein, mainly in the superficial or deep soft tissue, and only approximately 10% of the cases arise from superficial dermal vessels of the skin or mucous membranes . Although the clinical presentation of EHE may be variable, the neoplasm in the skin usually presents as a solitary, rarely multiple, erythematous papule, nodule, plaque, or hyperkeratotic or nonhealing ulcer that may subsequently extend to the underlying tissues, including the bone. In most cases the signs and symptoms of EHE are nonspecific and consist of a painful or tender mass or a slowly growing tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Epithelioid hemangioendothelioma (EHE) is a low‐grade, malignant, vascular neoplasm first described in 1982 by Weiss and Enzinger . It mostly presents as a solitary, slightly painful soft‐tissue tumor, although it has also been identified in the skin . EHEs occur without sex preference and at any age, although most described cases developed in adults (ages 30–50 yrs), and they are extremely uncommon during childhood, with only five infantile cases reported to date .…”

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confidence: 99%

Cutaneous Epithelioid Hemangioendothelioma on the Sole of a Child

Carranza-Romero

Molina-Ruiz

Monroy

et al. 2015

Pediatric Dermatology

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Epithelioid hemangioendothelioma (EHE) has been considered to be a low-grade malignant vascular neoplasm, although follow-up of recent series has demonstrated that EHE involving the skin and soft tissues should be better regarded as a fully malignant vascular tumor since it has more metastatic potential than previously thought. We report a case of an EHE involving the left sole of 6-year-old boy, the youngest patient with cutaneous EHE described to date. Immunohistochemical studies demonstrated a lymphatic endothelial line of differentiation for neoplastic cells. Cutaneous EHE is rare in childhood, with only five previously described cases.

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“…72 Epithelioid haemangioendothelioma limited to skin is rare, and typically presents as a solitary lesion with variable clinical appearances, including an erythematous nodule, papule or plaque, hyperkeratosis, or a non-healing ulcer. 57,[73][74][75][76] Cutaneous EHE has a significantly more favourable outcome than EHE arising at other locations. Metastatic disease is very rare, 57,74,77,78 and complete excision is adequate treatment in the majority of cases.…”

Section: Epithelioid Haemangioendotheliomamentioning

confidence: 99%

“…57,[73][74][75][76] Cutaneous EHE has a significantly more favourable outcome than EHE arising at other locations. Metastatic disease is very rare, 57,74,77,78 and complete excision is adequate treatment in the majority of cases. This contrasts sharply with mortality rates of EHE in other sites, ranging from 15% in soft tissue to 31% and 43% in bone and liver, respectively.…”

Section: Epithelioid Haemangioendotheliomamentioning

confidence: 99%

Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms

Costigan

Doyle

2016

Histopathology

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In recent years, there have been several important refinements in the classification of cutaneous mesenchymal neoplasms, including the description of new tumour types, along with the identification of novel and recurrent molecular genetic findings. In addition to providing new insights into tumour biology, many of these advances have had significant clinical consequences with regard to diagnostics, management, and prognostication. Newly described entities include pseudomyogenic haemangioendothelioma, haemosiderotic fibrolipomatous tumour, and fibroblastic connective tissue naevus, which are reviewed in the context of the principal differential diagnoses and significant clinical implications. Genetic characterization of several soft tissue tumour types that occur in the skin has resulted in the identification of diagnostically useful markers: ALK gene rearrangement with corresponding ALK protein expression by immunohistochemistry in epithelioid fibrous histiocytoma; the WWTR1-CAMTA1 fusion gene with CAMTA1 protein expression in epithelioid haemangioendothelioma; MYC amplification and overexpression in radiation-associated angiosarcoma; and EWSR1 gene rearrangement in cutaneous myoepithelial tumours. Finally, the classification of intradermal smooth muscle tumours and unclassified/pleomorphic dermal sarcoma has been refined, resulting in both improved classification and improved prognostication. Many of the tumour types listed above are encountered not only by specialist dermatopathologists, but also by practising general surgical pathologists, and this review should therefore provide a widely applicable update on the histological and molecular classification of cutaneous mesenchymal neoplasms, along with the appropriate use of ancillary diagnostic tests, in particular immunohistochemistry, in the evaluation of such lesions and their histological mimics.

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Ulcerated epithelioid hemangioendothelioma of the foot in childhood

Cited by 27 publications

References 27 publications

Cutaneous angiosarcoma: a current update

Cutaneous angiosarcoma: a current update

Cutaneous Epithelioid Hemangioendothelioma on the Sole of a Child

Advances in the clinicopathological and molecular classification of cutaneous mesenchymal neoplasms

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