Ulcerated nodule on the neck: Syphilitic chancre

A case of a pseudoneoplastic primary syphilis chancre on the neck

“…4 Interestingly, the presence of a primary syphilitic chancre on the neck raises the question of how this could occur, as it is exceedingly rare. [7][8][9][10][11][12] Primary syphilis inoculation occurs via a broken skin barrier or intact mucosal surface. 13 Previous reports of extragenital chancres have occurred on a mucosal surface or as a result of a compromised skin barrier.…”

Primary Syphilis of the Neck Mimicking Pyodermatitis

“…In the aforementioned chancres of the neck, the diagnosis was obtained by the combination of serology with the demonstration of TP within the lesion by means of TP-NAAT 11 or immunohistochemical analysis on skin biopsy. 8,9 Syphilis is rightly known as "the great imitator" owing to the wide spectrum of possible clinical manifestations, particularly in the second stage of the disease 12 ; our case fully confirms the polymorphism of syphilis.…”