Ulceration as a Possible Link between Duodenogastric Reflux and Neoplasms in the Stomach of Rats

Øvrebø, Kjell; Aase, Steinar; Grong, Ketil; Viste, Asgaut; Svanes, Knut; Sørbye, Halfdan

doi:10.1006/jsre.2002.6501

Cited by 6 publications

(2 citation statements)

References 45 publications

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“…A study from the Arab Emirates showed that 24 of 29 patients with ulcer perforation were HP-positive ( 13 C urea breath test) 8 days after operation, but population data were not available [39]. In an ongoing study in Bergen, Norway, 67% of ulcer perforation patients were HP-positive (serology) at the time of perforation and 37% were HP-positive ( 13 C urea breath test) 8 weeks after ulcer perforation surgery [40]. Thus ulcer perforation seem to differ from uncomplicated ulcer with regard to the importance of H. pylorii infection.…”

Section: Etiology Of Ulcer Perforationmentioning

confidence: 99%

Trends in Perforated Peptic Ulcer: Incidence, Etiology, Treatment, and Prognosis

2000

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After increasing steeply at the beginning of the twentieth century, ulcer perforation incidence during the last decades has declined in the young and in men, and it has risen among the elderly and in women. These changes can be attributed to a cohort phenomenon: Ulcer perforation risk is particularly common in the cohorts born after the turn of the twentieth century and is less common in previous and succeeding birth cohorts. A decline in total incidence is expected with the death of the high risk cohorts. Most ulcer perforations among subjects < 75 years of age can be attributed to smoking. Subjects with a history of ulcer perforation therefore have poorer long-term survival than the general population, most pronounced for younger generations. About one of four ulcer perforations can be attributed to the use of nonsteroidal antiinflammatory drugs, a risk factor of particular importance in the elderly. Ulcer perforation was frequently treated by gastric resection in former days, whereas suture, being the first method introduced in 1887, is the method of choice today. The introduction of antibiotics improved the prognosis of ulcer perforation surgery greatly. Postoperative lethality decreased until 1950 but has remained stable since then. Lethality is higher in the elderly and is higher after gastric than after duodenal perforation. The delay before surgical treatment is a strong determinant for lethality, complication rates, and hospital costs. Treatment delay seems to have increased during the last

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Section: Etiology Of Ulcer Perforationmentioning

confidence: 99%

Trends in Perforated Peptic Ulcer: Incidence, Etiology, Treatment, and Prognosis

2000

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“…In a majority of clinical cases, DGR frequently occurs after the surgical interventions (in 52.6 % of cases -after suturing the duodenal ulcer, in 15.5 % of cases -after cholecystectomy). The great number of experimental methods includes techniques, which requires a surgical intervention [17,[25][26].…”

Section: Discussionmentioning

confidence: 99%

Morphological Changes in the Upper Part of Digestive Tract in a Case of Experimental Duodenogastric Reflux

Romanenko

Komskyi²

2018

JBBBE

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Experimental reproduction of duodeno-gastric reflux was performed among Wistar line 28 rats, which were injected with 50 % solution of medical bile by intragastric way. Morphological study had been shown significant structural changes in the gingival tissues, mucous membrane of an esophagus, stomach and duodenum. In the epithelial layer of gingiva and esophagus was observed numerous infringements in a process of differentiation cells, in the stroma was shown phenomena of fibrosis in a papillary layer, microcirculation disorders. In the gastric mucosa had been found out multiple erosions, the glandular cells were increased. It was demonstrated vacuolization of the basal and thorn layers of the stomach epithelium. In the stroma defined phenomena of fibrosis and a dense lymphocyte infiltration with eosinophils. In the duodenum was determined desquamation of a glandular epithelium, superficial erosions of the villi, lympho–histio–plasmocytosis infiltration in a stroma, microvascular disorders. The given experiment demonstrates a role of functional disorders in the pathogenesis of combined pathology in the upper gastrointestinal tract.

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Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa

Tzaneva

2004

Pathology - Research and Practice

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Ulceration as a Possible Link between Duodenogastric Reflux and Neoplasms in the Stomach of Rats

Cited by 6 publications

References 45 publications

Trends in Perforated Peptic Ulcer: Incidence, Etiology, Treatment, and Prognosis

Trends in Perforated Peptic Ulcer: Incidence, Etiology, Treatment, and Prognosis

Morphological Changes in the Upper Part of Digestive Tract in a Case of Experimental Duodenogastric Reflux

Effects of duodenogastric reflux on gastrin cells, somatostatin cells and serotonin cells in human antral gastric mucosa

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