Ulcerative colitis: A case in Togo

Agoda-Koussema, LK; Anoukoum, T; Djibril, Aliou Moussa; Balaka, Abago; Folligan, K.; Adjenou, V.; Amouzou, K.D.; N'dakena, K.; Redah, R.

doi:10.1684/mst.2012.0012

Cited by 5 publications

(8 citation statements)

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“…In contrast, the incidence of UC continued to increase in previously low-incidence areas in Eastern Europe, Asia 32,37–39 and developing countries, such as Africa. 4059 Additionally, the incidence of CD is high in Canada and New Zealand, intermediate in Western Europe and the USA, and lower in Israel and South Africa. Although the overall rates are low, they appear to be increasing in some parts of Asia and South America.…”

Section: Resultsmentioning

confidence: 99%

“…There is also an emerging increase in the incidence and prevalence of IBD across Africa. 40,41,43,51,53,54,56,57,59 Wright et al studied IBD incidence rates observed in Cape Town's GI Clinic of Groote Schuur Hospital, South Africa (SA), from 1975-1980. In regards to CD and UC incidences, they reported 117 and 220 cases each, respectively, with a mean ± SEM follow-up of 6.1 ± 0.5 and 7.7 ± 0.4 years.…”

Section: Resultsmentioning

confidence: 99%

“…These differences with time in SA were significant ( P < 0.05). Despite an increased number of reports stemming from the continent of Africa, 4059 there was insufficient data to calculate the incidence rate for the entire African population.…”

Section: Resultsmentioning

confidence: 99%

“…110 Now, it is a global disease and its incidence in developing nations is rising. 42,111–113 Despite inadequate epidemiological data from developing parts of the world, the prevalence and incidence among blacks, Asians, and Hispanics has been reported with increasing frequencies 40–42,111,114 suggesting that the trend is indeed increasing worldwide. 42,52,112–116 Traditionally, developing nations have reported a lower prevalence of IBD, but the incidence is currently rising in many of these countries as they become more industrialized.…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Bowel Disease: An Expanding Global Health Problem

M’Koma

2013

Clin Med Insights Gastroenterol

264

225

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This review provides a summary of the global epidemiology of inflammatory bowel diseases (IBD). It is now clear that IBD is increasing worldwide and has become a global emergence disease. IBD, which includes Crohn’s disease (CD) and ulcerative colitis (UC), has been considered a problem in industrial-urbanized societies and attributed largely to a Westernized lifestyle and other associated environmental factors. Its incidence and prevalence in developing countries is steadily rising and has been attributed to the rapid modernization and Westernization of the population. There is a need to reconcile the most appropriate treatment for these patient populations from the perspectives of both disease presentation and cost. In the West, biological agents are the fastest-growing segment of the prescription drug market. These agents cost thousands of dollars per patient per year. The healthcare systems, and certainly the patients, in developing countries will struggle to afford such expensive treatments. The need for biological therapy will inevitably increase dramatically, and the pharmaceutical industry, healthcare providers, patient advocate groups, governments and non-governmental organizations should come to a consensus on how to handle this problem. The evidence that IBD is now affecting a much younger population presents an additional concern. Meta-analyses conducted in patients acquiring IBD at a young age also reveals a trend for their increased risk of developing colorectal cancer (CRC), since the cumulative incidence rates of CRC in IBD-patients diagnosed in childhood are higher than those observed in adults. In addition, IBD-associated CRC has a worse prognosis than sporadic CRC, even when the stage at diagnosis is taken into account. This is consistent with additional evidence that IBD negatively impacts CRC survival. A continuing increase in IBD incidence worldwide associated with childhood-onset of IBD coupled with the diseases’ longevity and an increase in oncologic transformation suggest a rising disease burden, morbidity, and healthcare costs. IBD and its associated neoplastic transformation appear inevitable, which may significantly impact pediatric gastroenterology and adult CRC care. Due to an infrastructure gap in terms of access to care between developed vs. developing nations and the uneven representation of IBD across socioeconomic strata, a plan is needed in the developing world regarding how to address this emerging problem.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Inflammatory Bowel Disease: An Expanding Global Health Problem

M’Koma

2013

Clin Med Insights Gastroenterol

264

225

View full text Add to dashboard Cite

show abstract

“…IBD incidence and prevalence is evolving worldwide [14,15] and is now contemplated to be an emergence global disease [4]. The burden of IBD varies in different countries and locations, especially when compared between developing [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and developed nations [32,33]. Data suggest that younger populations are more affected [6,34] and that the peak incidence of IBD occurs in children and adolescents [34,35].…”

Section: Introductionmentioning

confidence: 99%

The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview

M’Koma

2018

Gastrointestinal Disorders

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The gastrointestinal system where inflammatory bowel disease occurs is central to the immune system where the innate and the adaptive/acquired immune systems are balanced in interactions with gut microbes under homeostasis conditions. This article overviews the high-throughput research screening on multifactorial interplay between genetic risk factors, the intestinal microbiota, urbanization, modernization, Westernization, the environmental influences and immune responses in the etiopathogenesis of inflammatory bowel disease in humans. Inflammatory bowel disease is an expensive multifactorial debilitating disease that affects thousands new people annually worldwide with no known etiology or cure. The conservative therapeutics focus on the established pathology where the immune dysfunction and gut injury have already happened but do not preclude or delay the progression. Inflammatory bowel disease is evolving globally and has become a global emergence disease. It is largely known to be a disease in industrial-urbanized societies attributed to modernization and Westernized lifestyle associated with environmental factors to genetically susceptible individuals with determined failure to process certain commensal antigens. In the developing nations, increasing incidence and prevalence of inflammatory bowel disease (IBD) has been associated with rapid urbanization, modernization and Westernization of the population. In summary, there are identified multiple associations to host exposures potentiating the landscape risk hazards of inflammatory bowel disease trigger, that include: Western life-style and diet, host genetics, altered innate and/or acquired/adaptive host immune responses, early-life microbiota exposure, change in microbiome symbiotic relationship (dysbiosis/dysbacteriosis), pollution, changing hygiene status, socioeconomic status and several other environmental factors have long-standing effects/influence tolerance. The ongoing multipronged robotic studies on gut microbiota composition disparate patterns between the rural vs. urban locations may help elucidate and better understand the contribution of microbiome disciplines/ecology and evolutionary biology in potentially protecting against the development of inflammatory bowel disease.

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Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood

M’Koma¹,

Ware²,

Nabaweesi³

et al. 2023

MRAJ

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Inflammatory bowel disease (IBD) is a term for two autoimmune diseases encompassing Crohn’s disease (CD) and ulcerative colitis (UC) which are lifelong diseases affecting more than 3 million adults (1.3%) in the United States. IBD is characterized by chronic inflammation of the whole digestive system which results in damage to the gastrointestinal (GI) tract. IBD often emerges during adolescence and young adulthood. Maternal morbidity includes physical and psychological conditions that result from or are aggravated by pregnancy and have an adverse effect on a woman’s health, the baby’s health or both. Some women have health challenges that arise before or during pregnancy that could lead to complications. It is recommended for women to receive health care counseling before and during pregnancy. Compared to other developed countries, the United States has the highest rate of women dying of pregnancy related complications. During the past 25 years maternal mortality has been getting worse. African American women (AAW) with and/or without IBD are dying at significantly higher rates than other groups. This is linked to several factors, i.e., systemic, institutionalized, and structural racism in health-care delivery and subsequent toxic stress from people’s lived experiences of racism, limited knowledge about healthcare system function, lack of access to healthcare, (inclusiveness and insurance policies) all of which negatively impact these patients. African Americans (AAs) are also up to three times as likely to experience severe maternal morbidity: unexpected outcomes of labor and delivery, deficient or lacking prenatal care and social determinants of health like lack of transportation, adequate employment, limited literacy, and limited healthcare access contribute to poor health outcomes. Studies on IBD patients indicate Medicaid expansion is associated with reduced rates of maternal morbidity, particularly for African American Women (AAW) and increased access to preconception and prenatal services that make pregnancy and childbirth safer for parent and baby. Herein we examine the physiological changes of pregnancy in patients diagnosed with inflammatory bowel disease and their relationship perinatal outcomes and parenthood.

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Ulcerative colitis: A case in Togo

Cited by 5 publications

References 0 publications

Inflammatory Bowel Disease: An Expanding Global Health Problem

Inflammatory Bowel Disease: An Expanding Global Health Problem

The Multifactorial Etiopathogeneses Interplay of Inflammatory Bowel Disease: An Overview

Managing Pregnancy and Nursing Affecting African American Women with Inflammatory Bowel Disease: Clinical Outcomes and Parenthood

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