Ulcerative Colitis Accompanied by Idiopathic Thrombocytopenic Purpura and &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection

Etou, Takeshi; Iizuka, Masahiro; Ohshima, Atsushi; Yagisawa, Hitoshi; Yamano, Hiro‐o; Ishii, Tôru; Sagara, Shiho

doi:10.2169/internalmedicine.52.8856

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Of the remaining nine cases, eight responded well but one patient continued to have recurrent ITP despite colectomy (3). In one case, ITP resolved with H. pylori eradication (4). …”

Section: Resultsmentioning

confidence: 99%

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Immune thrombocytopenic purpura in ulcerative colitis: a case report and systematic review

Chandra

Finn

Obah

2014

Journal of Community Hospital Internal Medicine Perspectives

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Over 100 extraintestinal manifestations are reported in ulcerative colitis (UC). A commonly reported hematological manifestation is autoimmune hemolytic anemia. On rare occasions, immune thrombocytopenic purpura (ITP) has been reported with UC. The presence of thrombocytopenia can complicate the clinical scenario as the number of bloody bowel movements is an important indicator of disease activity in UC. A proposed theory for this association is antigenic mimicry between a platelet surface antigen and bacterial glycoprotein. We are reporting a case of UC and associated ITP managed successfully with anti-TNF therapy. We also performed a systemic review of case reports and a case series reporting this association.

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“…Of the remaining nine cases, eight responded well but one patient continued to have recurrent ITP despite colectomy (3). In one case, ITP resolved with H. pylori eradication (4). …”

Section: Resultsmentioning

confidence: 99%

“…The infection needs to be eradicated if presented. Refractory cases respond to colectomy and splenectomy but are rarely necessary (4). We are reporting a second case where a colectomy was avoided by using anti-tumor necrosis factor therapy (9).…”

Section: Discussionmentioning

confidence: 99%

Immune thrombocytopenic purpura in ulcerative colitis: a case report and systematic review

Chandra

Finn

Obah

2014

Journal of Community Hospital Internal Medicine Perspectives

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“…The finding of normocellular bone marrow with increased megakaryocyte counts indicated a diagnosis of ITP. Although ITP has been associated with Helicobacter pylori infection, including in patients with UC ( 7 ), our patient was negative for anti- H. pylori IgG. Thus, the ITP in our patient was considered to be an extraintestinal manifestation of UC; however, it should be noted that the actual association between ITP and UC has yet to be determined.…”

Section: Discussionmentioning

confidence: 61%

The Effective Treatment with Cyclosporine of a Ulcerative Colitis Patient with Concurrent Idiopathic Thrombocytopenic Purpura Who Subsequently Developed Spontaneous Pneumomediastinum

et al. 2017

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Although extraintestinal manifestations of inflammatory bowel diseases are not uncommon, few reports have described concurrent idiopathic thrombocytopenic purpura (ITP). Spontaneous pneumomediastinum is also a rare complication of ulcerative colitis (UC). This report describes the case of a 14-year-old boy who experienced recurrent ulcerative colitis 3 months after temporary improvement following treatment with prednisolone (20 mg/day) and granulocyte/monocyte adsorption apheresis. His platelet counts decreased, suggesting ITP. The dosage of prednisolone was increased to 60 mg/day; however, his thrombocytopenia did not improve and he suddenly developed pneumomediastinum. A continuous infusion of cyclosporine increased his platelet counts and improved his ulcerative colitis. Cyclosporine should be considered when steroid-resistant ITP accompanies UC.

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“…It is also concerned that either thrombocytopenia severity or disease duration impacts platelet resolution [7]. We have tabulated the cases of ITP that showed full recovery after H. pylori eradication therapy (Table 2) [3,5,[8][9][10][11]. The pathophysiology of ITP induced by H. pylori remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review

Sadia¹,

Abro²,

Ali³

et al. 2022

Cureus

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Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the production of autoantibodies against the platelet surface antigens. ITP is a diagnosis of exclusion and is further categorized into primary and secondary ITP. The etiology of primary ITP is idiopathic, and secondary ITP is caused by infections and autoimmune disorders. Among infectious etiology of ITP, human immunodeficiency virus, herpes virus, and hepatitis B and C virus are common. Helicobacter pylori (H. pylori) is a rare cause of ITP, and the relationship between ITP and H. pylori is highlighted in the literature. We report a case of ITP in an adult female who presented with hematemesis and petechial rash in the lower limbs. Her initial laboratory results demonstrated thrombocytopenia, and the results of her gastric biopsy and stool antigen were positive for H. pylori. She was diagnosed with ITP induced by H. pylori because additional causes of ITP were not identified. Her clinical improvement and platelet recovery after initiating H. pylori eradication therapy were consistent with H. pylori-induced ITP.

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Ulcerative Colitis Accompanied by Idiopathic Thrombocytopenic Purpura and <i>Helicobacter pylori</i> Infection

Cited by 6 publications

References 14 publications

Immune thrombocytopenic purpura in ulcerative colitis: a case report and systematic review

Immune thrombocytopenic purpura in ulcerative colitis: a case report and systematic review

The Effective Treatment with Cyclosporine of a Ulcerative Colitis Patient with Concurrent Idiopathic Thrombocytopenic Purpura Who Subsequently Developed Spontaneous Pneumomediastinum

Immune Thrombocytopenia Induced by Helicobacter pylori Infection: A Case Report and Literature Review

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