Ulcerative colitis and clinical course: Results of a 5-year population-based follow-up study (the IBSEN study)

Henriksen, Magne; Jahnsen, Jørgen; Lygren, Idar; Sauar, Jostein; Kjellevold, Øystein; Schulz, Tom; Vatn, Morten H.; Moum, Bjørn

doi:10.1097/01.mib.0000225339.91484.fc

Cited by 237 publications

(181 citation statements)

References 29 publications

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…4 The overall relapse rate in this study, in which patients had a median follow-up of 7.8 years, was 57%. This is remarkably less than what was found by some authors, 20,22,23 but similar to recent reports, particularly the multicenter European study. 10 In this study a cumulative relapse rate of 57% (53%-61%) at 5 years and 67% (63%-71%) at 10 years were reported.…”

contrasting

confidence: 55%

Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

contrasting

confidence: 55%

Ulcerative colitis in a Southern European country: A national perspective

Portela

Magro²,

Lago³

et al. 2010

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

“…This observation is also consistent with other datasets. Previously reported rates of pancolitis in patients with UC, from prospective childhood studies (80%-90%) 7,19,20 are far higher than those from prospective adult studies (24% pancolitis 21 or 33% extensive colitis 22 ). Our study not only provides further replication of these data, but also directly compares a childhood-onset and adult-onset cohort within the same population using the Montreal classification (82% of childhood-onset UC patients had extensive colitis at last follow-up compared with 47% of adult-onset UC).…”

Section: Discussionmentioning

confidence: 92%

Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease

et al. 2008

View full text Add to dashboard Cite

See Dubinsky MC et al on page 1105 in CGH;See editorial on page 1038. Background & Aims:Childhood-onset inflammatory bowel disease (IBD) might be etiologically different from adult-onset IBD. We analyzed disease phenotypes and progression of childhood-onset disease and compared them with characteristics of adult-onset disease in patients in Scotland. ; 43% vs 3%; P < .0001; OR, 23.36; 95% CI, 13.45-40.59) with less isolated ileal (L1; 2% vs 31%; P < .0001; OR, 0.06; 95% CI, 0.03-0.12) or colonic disease (L2; 15% vs 36%; P < .0001; OR, 0.31; 95% CI, 0.21-0.46). UC was extensive in 82% of the children at diagnosis, versus 48% of adults (P < .0001; OR, 5.08; 95% CI, 2.73-9.45); 46% of the children progressed to develop extensive colitis during followup. Forty-six percent of children with CD and 35% with UC required immunomodulatory therapy within 12 months of diagnosis. The median time to first surgery was longer in childhood-onset than adult-onset patients with CD (13.7 vs 7.8 years; P < .001); the reverse was true

show abstract

“…Chronic continuous symptoms and chronic relapsing symptoms were experienced by 36 (9%) and 129 (31%) patients, respectively (29). In our study, when patients were classified by their clinical courses using number of relapses, 13.8% patients were classed as chronic intermittent with frequent attacks, and only 6.4% patients had chronic continuous symptoms.…”

Section: Discussionmentioning

confidence: 98%

“…In addition to the number of relapses, the need for surgery is an objective criterion when assessing the clinical course of UC (29), representing a useful end-point measure of disease severity. In the studies from Western countries, surgical operations are reportedly performed in 20%-25% of patients with UC (1,30), and in a population-based study from Stockholm, the cumulative risk of colectomy after 5 years was 20% (95% CI, 18%-22%).…”

Section: Discussionmentioning

confidence: 99%

Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey

Kalkan

Dağlı²,

Kekilli³

et al. 2015

Turk J Gastroenterol

View full text Add to dashboard Cite

Background/Aims: We aimed to describe the clinical course of Ulcerative colitis (UC) and the factors that predict the need for total colectomy in Turkish patients with severe UC receiving regular follow up. Materials and Methods: We analyzed the demographic and clinical characteristics of 612 patients with UC receiving regular follow up between 1994 and 2010 in a tertiary referral center in Ankara. Results: Men accounted for 58% of patients (M:F ratio, 1.4:1), and the mean age at diagnosis was 37.9 years. Of these, 32% had distal colitis and 8.8% had further extension, and 39 patients (6.4%) had chronic active disease. Steroid dependency and steroid resistance rates were 7.5% and 17.2%, respectively. In multivariate analysis, steroid dependency (p=0.04), steroid resistance (p=0.002), further extension (p<0.001), presence of extensive disease (p=0.006), and chronic active disease (p<0.001) were independent predictors of the need for total colectomy. Patients with chronic active disease had lower total colectomy free survival (p<0.001). Conclusion: The predictors of total colectomy were comparable with those previously reported in the literature. However, we identified further extension in disease localization to predict the need for total colectomy.

show abstract

Ulcerative colitis and clinical course: Results of a 5-year population-based follow-up study (the IBSEN study)

Abstract: The disease course and prognosis of UC appears better than previously described in the literature. The frequency of surgery was low, and only a minority of the patients had symptoms that interfered with their everyday activities 5 years after diagnosis.

Cited by 237 publications

References 29 publications

Ulcerative colitis in a Southern European country: A national perspective

Ulcerative colitis in a Southern European country: A national perspective

Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease

Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey

Contact Info

Product

Resources

About