Ulcerative Colitis and Colorectal Cancer

Abstract

Close surveillance and perhaps even prophylactic proctocolectomy should be recommended for patients given a diagnosis of pancolitis, especially those who are less than 15 years of age at diagnosis.

Microsomal Prostaglandin E Synthase-1 Is Overexpressed in Inflammatory Bowel Disease

“…Patients with longstanding IBD are at increased risk for developing colon cancer (64). Neoplasia develops in the context of increased epithelial cell turnover and regeneration induced by the chronic inflammatory state (65).…”

Leukotriene D4 Mediates Survival and Proliferation via Separate but Parallel Pathways in the Human Intestinal Epithelial Cell Line Int 407

“…Sheng et al (10) have suggested that there is a connection between inflammation and the development of cancer, which is also supported by results showing that ulcerative colitis is associated with an increased incidence of neoplastic transformation (11) and the observation that colon cancer is underrepresented in populations treated with nonsteroidal anti-inflammatory drugs (12). Furthermore, in previous experiments using nontransformed intestinal epithelial cells (13), we found that prolonged exposure to LTD 4 resulted in up-regulation of several proteins associated with colon carcinogenesis, among others cyclooxygenase-2, ␤-catenin, and the cell survival protein Bcl-2 (13,14).…”

Colorectal cancer in the world: incidence, mortality and risk factors

“…Generally, the cumulative incidence of CRC in patients with UC has an increasing trend. For instance, at 20, 30 and 35 years after diagnosis of UC, the percentage of UC-diagnosed patients afflicted with CRC was 5-10%, ISSN: 2198-4093 www.bmrat.org 12-20%, and 30%, respectively (Ekbom et al, 1990;Gyde et al, 1988). There are other factors that may be associated with the risk of developing CRC in patients with IBD.…”