Ulcerative Colitis and Common Variable Immunodeficiency: Case Report

Arruda, Silvana Gonçalves Brito de; Silva, Almerinda Maria do Rego; Barros, Kátia Simone Cezário de; Cunha, Ana Maria

doi:10.1002/ibd.20607

Cited by 5 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47,57,80–82,101 Unlike XLA and IgA deficiency, IBD-like disease is reported more commonly in patients with CVID, suggesting that this tendency toward inflammation is driven by T cells or, more likely, T-cell dysregulation; the exact pathogenesis, however, is still unknown. Distinguishing inflammatory disease from infectious disease can be challenging because both can have symptoms and signs of diarrhea, weight loss, and malabsorption.…”

Section: Predominantly Antibody Deficiencymentioning

confidence: 99%

Diagnosis and Treatment of Gastrointestinal Disorders in Patients With Primary Immunodeficiency

Agarwal

Mayer

2013

Clinical Gastroenterology and Hepatology

212

160

View full text Add to dashboard Cite

Gastrointestinal disorders such as chronic or acute diarrhea, malabsorption, abdominal pain, and inflammatory bowel diseases can indicate immune deficiency. The gastrointestinal tract is the largest lymphoid organ in the body, so it is not surprising that intestinal diseases are common among immunodeficient patients. Gastroenterologists therefore must be able to diagnose and treat patients with primary immunodeficiency. Immune-related gastrointestinal diseases can be classified as those that develop primarily via autoimmunity, infection, an inflammatory response, or malignancy. Immunodeficient and immunocompetent patients with gastrointestinal diseases present with similar symptoms. However, intestinal biopsy specimens from immunodeficient patients often have distinct histologic features, and these patients often fail to respond to conventional therapies. Therefore, early recognition of symptoms and referral to an immunologist for a basic immune evaluation is required to select appropriate treatments. Therapies for primary immunodeficiency comprise immunoglobulin replacement, antibiotics, and, in severe cases, bone marrow transplantation. Treatment of immunodeficient patients with concomitant gastrointestinal disease can be challenging, and therapy with immunomodulators often is required for severe disease. This review aims to guide gastroenterologists in the diagnosis and treatment of patients with primary immunodeficiency.

show abstract

Section: Predominantly Antibody Deficiencymentioning

confidence: 99%

Diagnosis and Treatment of Gastrointestinal Disorders in Patients With Primary Immunodeficiency

Agarwal

Mayer

2013

Clinical Gastroenterology and Hepatology

212

160

View full text Add to dashboard Cite

show abstract

“…Inflammatory disease is also common, and mainly involves the colon (12). Differentiating between diarrhea of infectious or inflammatory origin is difficult (9).…”

Section: Discussionmentioning

confidence: 99%

Effective treatment of common variable immunodeficiency associated diarrhea

Guevara

Aguilar

2009

Rev. esp. enferm. dig.

View full text Add to dashboard Cite

Common variable immunodeficiency disorder (CVID), the commonest symptomatic primary antibody deficiency syndrome, is characterised by recurrent bacterial infections, particularly of the upper and lower airways; it is also associated with an increased incidence of autoimmune and neoplastic disorders.CVID has a high prevalence of infectious, inflammatory and neoplastic gastrointestinal diseases. Up to 60% of the patients with non-treated CVID develop diarrhea and 10% associated idiopathic malabsorption with weight loss.The case of a 50-year-old woman with CVID-associated diarrhea, abdominal pain and bloating of one year´s duration is reported. An exhaustive evaluation made for secondary causes of her symptoms was unrevealing; she was treated with loperamide and diet, without improvement. She later followed a course of oral budesonide for 3 months; her clinical symptoms disappeared and her quality of life improved.In conclusion, we report the case of a patient with CVID-related chronic diarrhea who responded well to oral budesonide treatment. This outcome provides the gastroenterologist with a new therapeutic option in this difficult group of patients.

show abstract