Ulcerative colitis and HLA phenotype.

Cottone, Mario; Bunce, Mike; Taylor, Chris; Ting, A.; Jewell, D P

doi:10.1136/gut.26.9.952

Cited by 40 publications

(19 citation statements)

References 10 publications

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“…In keeping with earlier findings [10], the level of antigen B7 was also reduced in our patients. There was no other significant HLA association in the whole group, a finding also reported in other studies [6,18].…”

Section: Discussionsupporting

confidence: 74%

“…We could not find a reasonable explanation for the phenomenon. Our eases were younger than those of earlier reports [4,6,18], we also started the follow-up from the diagnosis of the disease. Whether the immunoglobulin reduction observed was caused by sulphasalazine or whether it was due to immune regulatory disturbances in ulcerative colitis remains to be solved.…”

Section: Discussionmentioning

confidence: 53%

“…Some studies have shown an association of the disease with HLA antigens B27 and Bw35 in Caucasian populations [3] and B5 in Japanese and Sicilian populations [1,3,4] while others have failed to confirm these findings [6,18]. The frequency of antigen B7 has been found to be decreased in patients with ulcerative colitis [10].…”

Section: Introductionmentioning

confidence: 96%

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Transient IgA and IgM deficiencies are frequent in children with ulcerative colitis

1988

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Serum immunoglobulin levels in 22 children with ulcerative colitis were followed for 2 years after diagnosis of the disease. A statistically significant depression of IgA, IgM, and IgG was noticed; depression of IgA and IgM was most frequent. The depression of immunoglobulin levels was transient and was most prominent during the first year of treatment. All patients in the study received sulphasalazine. Disease activity or steroid medication had no influence on immunoglobulin levels. The development of immunoglobulin deficiencies was not connected with any HLA antigen; we found decreased frequency of antigen B7 in the whole group.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 53%

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Transient IgA and IgM deficiencies are frequent in children with ulcerative colitis

1988

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“…In other studies the difference did not reach statistical significance [28,29]. Finally, in some studies a decreased frequency of HLA-DR2 was observed [30,31]. The studies from Japan and the USA are of interest because of the more homogeneous population (Japanese and Jewish), which would diminish genetic heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD)

Bouma¹,

Pool²,

Crusius³

et al. 1997

Clinical and Experimental Immunology

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SUMMARYFamily and epidemiological studies support a genetic susceptibility to UC and CD. Conflicting reports regarding associations between UC and HLA-DR2 and between CD and various HLA alleles have been published. The aim of this study was to determine whether molecularly defined HLA-DR genes are associated with these diseases in a Dutch group of patients. Fifty-nine unrelated Dutch UC patients and 89 CD patients were typed using DNA-based methods. A total of 2400 healthy local blood donors served as controls. The phenotype frequency of the HLA-DRB1*15 allele was increased in UC patients compared with controls (42% versus 26% in controls; P = 0 . 006; odds ratio (OR) = 2 . 1), and was predominantly found in female patients (53% versus 24%; P = 0 . 001; OR = 3 . 5). The DRB1*15 allele was increased in UC patients having a positive family history (P = 0 . 01; OR = 5 . 8). Among the 16 patients who showed an increase in extent of disease during follow up, 10 were DRB1*15 + (P = 0 . 002; OR = 4 . 8). The frequency of the DRB1*13 allele was decreased in patients with UC (15% versus 28% in controls; P = 0 . 04; OR = 0 . 5). In CD, no association was observed between disease or particular clinical subgroups and any allele tested. The present study provides additional evidence for the genetic association between UC and HLA-DRB1*15, and supports recent findings that the susceptibility gene(s) for CD is not located in the HLA class II region.

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“…The genes that nificance, or was not increased [21,[35][36][37][38][39][40][41]. Two studies found a decreased prevalence of HLA-DR2 [42,43]. code for IL-1 , IL-1 and the IL-1ra are located on the long arm of chromosome 2.…”

Section: Hla Gene Polymorphism In Ibd the Major Histocompatibility Comentioning

confidence: 99%

Genetics of Inflammatory Bowel Disease. The Candidate Gene Approach: Susceptibility versus Disease Heterogeneity

Peña

1998

Dig Dis

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Ulcerative colitis and Crohn’s disease are complex diseases of unknown etiology. Several genes are involved in the susceptibility. These genes are necessary to suffer from these diseases but not sufficient. Environmental factors trigger the inflammatory response. Evidence is accumulating that this response is abnormal in these patients. Therefore, the study of genes that are involved in the regulation of the inflammation may help to clarify the pathogenesis of the disease. The working hypothesis is that HLA and cytokine gene polymorphisms, of extreme importance in the regulation of inflammation, contribute to determining the heterogeneity of the disease and the prognosis. In this case, the candidate genes are those involved in the regulation of the immune response of the host. These studies may be of great importance in the tailoring of an appropriate treatment for particular subgroups of patients. A premise for the success of these studies is to use a solid classification, which should take into account the dynamic process and the natural evolution of the disease; to use a carefully selected and ethnically matched group of healthy controls, and to use the advanced molecular biological typing techniques. In the present article, this concept is explored by taking into account some of the recent findings obtained with the HLA and cytokine gene polymorphisms in inflammatory bowel diseases. The results support the concept that these gene polymorphisms are of greater importance in determining the severity of the disease than in determining the susceptibility to suffer from the disease. From this point of view, these studies are complementary and a necessary addition to studies using the whole genome approach in the effort to understand the genetics of these chronic multifactorial diseases.

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Ulcerative colitis and HLA phenotype.

Cited by 40 publications

References 10 publications

Transient IgA and IgM deficiencies are frequent in children with ulcerative colitis

Transient IgA and IgM deficiencies are frequent in children with ulcerative colitis

Evidence for genetic heterogeneity in inflammatory bowel disease (IBD); HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn's disease (CD)

Genetics of Inflammatory Bowel Disease. The Candidate Gene Approach: Susceptibility versus Disease Heterogeneity

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