Ulcerative colitis and isotretinoin: is there a causal relationship?

Bendezú-García, Rogger Álvaro; Hernández-Martínez, Álvaro; Patrón-Román, Gustavo Oliver; Bravo-Castillo, Francisco; Vega-Sáenz, José Luis

doi:10.4321/s1130-01082014000200016

Cited by 5 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many scholars found no evidence supporting that ISO caused IBD/ulcerative colitis. 14 , 19 Sakhamuru et al 20 reviewed 33 publications and found that most studies showed no significant association between the use of ISO and the development of ulcerative colitis. The Brazilian Society of Dermatology appointed eight experts from five universities to reach a consensus on the indications for ISO, and the experts agreed that there was no causal relationship between IBD and ISO.…”

Section: Resultsmentioning

confidence: 99%

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Ding¹,

Zheng²,

Jin³

2023

CCID

View full text Add to dashboard Cite

Isotretinoin (ISO) is a powerful vitamin A derivative that offers the potential for treatment of permanent remission of acne; however, its potential side effects on both physiological and psychological aspects limit its application. This article reviews the side effects of ISO from physiological and psychological aspects in detail, to better screen the suitable population of ISO and improve the efficiency of clinical treatment. Our findings indicate that ISO may cause teratogenicity, skin reactions, ocular reactions, changes in blood indicators, and occasional acne fulminans. To optimize clinical treatment, more attention should be paid to identifying the specific conditions under which these reactions occur, how severe they are, and how they subside to alleviate patient concerns. Regarding the controversial issue of psychological side effects caused by ISO, researchers should shift their focus to the psychological problems that acne itself may cause.

show abstract

Section: Resultsmentioning

confidence: 99%

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Ding¹,

Zheng²,

Jin³

2023

CCID

View full text Add to dashboard Cite

show abstract

“…Similarly, Crockett et al studied the casual association between isotretinoin usage and IBD, which concluded that there is no adequate proof to confirm or refuse whether the association between IBD and isotretinoin exists [17]. The latter was supported by Bendezú-García et al [25].…”

Section: Isotretinoin Exposure and The Risk Of Ibd; Evidence-basedmentioning

confidence: 96%

Isotretinoin-Induced Inflammatory Bowel Disease: Is There a Real Association?

Miqdad¹,

Alatta²,

Abdelsamad³

et al. 2022

Cureus

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is an autoimmune inflammatory disorder that affects the gastrointestinal system with an annual increase in incidence and prevalence worldwide. While the precise cause behind IBD remains obscured, certain genetic susceptibilities, in addition to environmental factors, may trigger the stimulation of the immunoinflammatory system against the gastrointestinal system, eventually resulting in IBD. Furthermore, certain medications have been proposed to increase the risk of developing IBD, such as isotretinoin. IBD has been reported during the post-marketing phase of isotretinoin. Subsequently, IBD development was added as a potential gastrointestinal adverse effect of isotretinoin. This review article aims to evaluate the possible association between isotretinoin exposure and the development of inflammatory bowel disease. We enrolled 32 relevant studies, including case reports, case-control, and cohort studies. The results were critically analyzed and reviewed by independent authors to answer the research question and achieve the primary endpoint.

show abstract

“…Since that time, several case-control and cohort studies have been done to study the possibility of this etiological link further. A case-control study done with a population of women using oral contraceptives concluded no association between the vitamin A analogue and ulcerative colitis (95% confidence interval=0.52-1.90) [ 5 ]. Another study, a retrospective population-based cohort, analyzed data from patients using isotretinoin, and similarly concluded that there was no connection between isotretinoin use and IBD [ 5 ].…”

Section: Reviewmentioning

confidence: 99%

“…In addition, a particularly interesting association that has been repeatedly hypothesized in current literature is that the use of isotretinoin in the treatment of P. acnes is associated with an increased incidence of ulcerative colitis. If significant, this association could make it necessary to avoid isotretinoin use in patients prone to developing ulcerative colitis and its associated autoimmune conditions, such as primary sclerosing cholangitis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Propionibacterium acnes in the Pathogenesis of Sarcoidosis and Ulcerative Colitis: How This Connection May Inspire Novel Management of These Conditions

Sakhamuru

Kambampati

Wasim

et al. 2020

Cureus

View full text Add to dashboard Cite

A lesser-acknowledged role of Propionibacterium acnes is its effect on the development of sarcoidosis. This literature review not only further explores this association but also that of Propionibacterium acnes and other inflammatory conditions, such as ulcerative colitis and pyoderma gangrenosum, acne, ulcerative colitis syndrome (PAC syndrome). This article reviews the effect that isotretinoin, a commonly used treatment of acne, has on the pathogenesis of ulcerative colitis, and the immune dysregulation and genetic susceptibility of individuals prone to developing acne, sarcoidosis, and ulcerative colitis. Literature for this article review was obtained from PubMed by utilizing both regular keywords and medical subject heading (MeSH) subheadings for data gathering. Regular keywords were: Propionibacterium acnes, sarcoidosis, ulcerative colitis, and isotretinoin. MeSH subheadings used were: Propionibacterium acnes/immunology, Propionibacterium acnes/pathogenicity, Propionibacterium acnes/genetics, sarcoidosis/immunology, and sarcoidosis/genetics. Following the application of inclusion and exclusion criteria, a total of 5172 publications were obtained. A total of 5086 publications were removed due to a lack of relevancy to outcomes of interest. The remaining 86 publications from all the regular and MeSH keywords were selected due to relevancy to outcomes of interest. Following this, a refined manual search was done, with the removal of duplicates, and 33 publications from PubMed were selected for review. Following a review of these records, Propionibacterium acnes was repeatedly concluded to be a causative agent of sarcoidosis. Variable results for the association between Propionibacterium acnes and ulcerative colitis were found. Most studies showed no significant association between the use of isotretinoin and the development of ulcerative colitis. A strong overlapping role of genetic susceptibility and immune dysregulation in the pathogeneses of sarcoidosis, ulcerative colitis, and Propionibacterium acnes was found.

show abstract

Ulcerative colitis and isotretinoin: is there a causal relationship?

Cited by 5 publications

References 0 publications

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Isotretinoin-Induced Inflammatory Bowel Disease: Is There a Real Association?

The Role of Propionibacterium acnes in the Pathogenesis of Sarcoidosis and Ulcerative Colitis: How This Connection May Inspire Novel Management of These Conditions

Contact Info

Product

Resources

About