Ulcerative Colitis and Thrombotic Thrombocytopenic Purpura

Almogy, Gidon; Sachar, David B.; Gans, William; Greenstein, Adrian J.

doi:10.1097/00004836-200103000-00016

Cited by 10 publications

(11 citation statements)

References 12 publications

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“…Although the patient reported by Almogy et al [3] did not respond to PEX in conjunction with medical therapy, their patient did recover after proctectomy and splenectomy were performed. Our two patients responded to prolonged PEX (21 and 14 PEXs, respectively, 1.5 plasma volumes each), in conjunction with medical therapy.…”

Section: Discussionmentioning

confidence: 76%

“…One of our patients and the patient of Almogy et al [3] received vincristine. The role of this drug in the response of our patient is unclear.…”

Section: Discussionmentioning

confidence: 79%

“…Once recognized, the course of PEX therapy may be prolonged, and other modalities (e.g., splenectomy) may be needed to achieve remission [3].…”

Section: Discussionmentioning

confidence: 99%

“…One patient also received vincristine. On review of the literature, we found only one prior reported similar case: a 30-yearold female with an exacerbation of chronic UC who developed the classical pentad of TTP [3]. In this previously reported case, the severity of the UC necessitated subtotal colectomy, and the TTP did not respond to high-dose steroids, PEX, or vincristine, but, rather, necessitated splenectomy and proctectomy.…”

Section: Introductionmentioning

confidence: 87%

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First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

Baron

Jeon

Glunz

et al. 2002

J of Clinical Apheresis

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The association of ulcerative colitis (UC) and thrombotic thrombocytopenic purpura (TTP) is rare. Only one prior patient with these two syndromes has been reported in the literature. In that case, splenectomy and proctectomy were performed to control the symptoms of TTP. We present two patients with UC who developed TTP and were successfully treated with multiple plasma exchanges (PEXs) in conjunction with medical therapy without the necessity for surgical intervention. Acquired TTP may be another extraintestinal autoimmune feature of UC. TTP in association with UC may be refractory to high-dose steroids and PEX, possibly requiring vincristine and splenectomy, as in the one previously reported case, to achieve remission.

show abstract

Section: Discussionmentioning

confidence: 76%

“…One of our patients and the patient of Almogy et al [3] received vincristine. The role of this drug in the response of our patient is unclear.…”

Section: Discussionmentioning

confidence: 79%

“…Once recognized, the course of PEX therapy may be prolonged, and other modalities (e.g., splenectomy) may be needed to achieve remission [3].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 87%

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First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

Baron

Jeon

Glunz

et al. 2002

J of Clinical Apheresis

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“…2 TTP/HUS associated with Crohn's disease (CD) was rare previously. [3][4][5] However, TTP/HUS eventually occurred a long time after the diagnosis of CD in those cases. We herein report a patient with CD who presented with TTP/HUS.…”

Section: Introductionmentioning

confidence: 96%

A Patient with Crohn's Disease who Presented with Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome

Unverdi¹,

Çeri²,

Öztürk

et al. 2011

Renal Failure

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Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) is characterized with fever, purpura, anemia due to microangiopathic hemolysis, thrombocytopenia, kidney damage, and neurologic symptoms. The development of TTP/HUS during the course of inflammatory bowel diseases was rarely reported. However, coexistence of TTP/HUS and Crohn's disease in the same patient has not been reported previously. We herein present a case of TTP/HUS who presented with Crohn's disease. He responded to cyclosporine treatment.

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Correlation of thrombotic thrombocytopenic purpura disease activity with von willibrand factor-cleaving protease level in ulcerative colitis

Ahmed

Siddiqui

Chandrasekaran

2004

The American Journal of Medicine

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Ulcerative Colitis and Thrombotic Thrombocytopenic Purpura

Cited by 10 publications

References 12 publications

First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange

A Patient with Crohn's Disease who Presented with Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome

Correlation of thrombotic thrombocytopenic purpura disease activity with von willibrand factor-cleaving protease level in ulcerative colitis

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