Ulcerative Colitis-associated <i>E. coli</i> pathobionts potentiate colitis in susceptible hosts

Yang, Hyungjun; Mirsepasi-Lauridsen, Hengameh Chloé; Struve, Carsten; Allaire, Joannie M.; Sivignon, Adeline; Vogl, Wayne; Bosman, Else S.; Ma, Cun‐Gen; Fotovati, Abbas; Reid, Gregor S. D.; Li, Xiaoxia; Petersen, Andreas Munk; Gouin, Sébastien G.; Barnich, Nicolas; Jacobson, Kevan; Yu, Hong; Krogfelt, Karen A.; Vallance, Bruce A.

doi:10.1080/19490976.2020.1847976

Cited by 37 publications

(23 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ulterative colitis is a chronic inflammatory disease of colon and rectum. Its pathogenesis is closely related to intestinal microbial imbalance [29]. Methods 9 of the top 10 candidate microorganisms related to Ulcerative colitis predicted by us have been confirmed by experiments, as shown in Table 3.…”

Section: Case Studiessupporting

confidence: 63%

A novel bi-directional heterogeneous network selection method for disease and microbial association prediction

Guan

Zhang

2022

Preprint

View full text Add to dashboard Cite

Microorganisms in the human body have a great impact on human health. Therefore, mastering the potential relationship between microorganisms and diseases is helpful to understand the pathogenesis of diseases and is of great significance to the prevention, diagnosis and treatment of diseases.In order to predict the potential microbial disease relationship, we propose a new computational model. Firstly, a bi-directional heterogeneous microbial disease network is constructed by integrating multiple similarities, including Gaussian kernel similarity, microbial function similarity, disease semantic similarity and disease symptom similarity. Secondly, the neighbor information of the network is learned by random walk; Finally, the selection model is used for information aggregation, and the microbial disease node pair is analyzed. Our method is superior to the existing methods in leave-one-out cross-validation and five-fold cross-validation. Moreover, in case studies of different diseases, our method is effective.

show abstract

Section: Case Studiessupporting

confidence: 63%

A novel bi-directional heterogeneous network selection method for disease and microbial association prediction

Guan

Zhang

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Studies have confirmed that E. coli is closely related to the occurrence of UC. 36 Here, we preliminarily investigated the number of E. coli organisms. Similar to LPS, the number of E. coli increased significantly in the DSS group.…”

Section: Discussionmentioning

confidence: 99%

Short‐term treatment with zingerone ameliorates dextran sulfate sodium‐induced mouse experimental colitis

et al. 2022

View full text Add to dashboard Cite

BACKGROUND Ulcerative colitis (UC) is a relapsing and chronic inflammatory disease of the gastrointestinal tract, which seriously threatens human health. Zingerone (ZO) has been proven to be effective for many diseases. The purpose of this study is to investigate the protective effects and potential mechanisms of ZO extracted from ginger on dextran sulfate sodium (DSS)‐induced mouse ulcerative colitis (UC). RESULTS The results showed that ZO alleviated the weight loss of UC model mice, reduced the disease activity index scores, and inhibited the shortening of colon length. ZO also improved DSS‐induced pathological changes in colon tissue and inhibited the secretion of pro‐inflammatory cytokines in colon and mesenteric lymph nodes. Further mechanism analysis found that ZO inhibited DSS‐induced nuclear factor‐κB pathway activation, and regulated peroxisome proliferator‐activated receptor γ (PPARγ) expression. To further explore whether PPARγ was involved in the anti‐UC effect of ZO, PPARγ inhibitor GW9662 was used. Although ZO also showed a protective effect on GW9662‐treated colitis mice, the protective role was significantly weakened. Importantly, the administration of GW9662 significantly aggravated UC compared with the ZO + DSS group. In addition, we preliminarily found that ZO had the effects of inhibiting DSS‐induced oxidative stress, maintaining intestinal barrier, and inhibiting the content of LPS and the population of Escherichia coli. CONCLUSIONS These results indicated that supplementation with ZO might be a new dietary strategy for the treatment of UC. © 2022 Society of Chemical Industry.

show abstract

“…At the mechanistic level, this phenotype appears to be primarily due to the regulatory function of IL-1R8 in epithelial cells. These changes result in increased weight loss, intestinal bleeding, local tissue damage and reduced mice survival ( 103 , 149 ), and susceptibility to Ulcerative Colitis-associated E. coli pathobionts ( 172 ). In addition, as reported above, IL-1R8 was essential for the anti-inflammatory role of IL-37 in this model in vivo , as well as in colonic organoids ( 173 ).…”

Section: Il-1r8 (Tir8/sigirr)mentioning

confidence: 99%

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease

et al. 2022

View full text Add to dashboard Cite

Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity, receptor antagonists, and an anti-inflammatory cytokine. The receptors for these ligands, the IL-1 Receptor (IL-1R) family, include signaling receptor complexes, decoy receptors, and negative regulators. Agonists and regulatory molecules co-evolved, suggesting the evolutionary relevance of a tight control of inflammatory responses, which ensures a balance between amplification of innate immunity and uncontrolled inflammation. IL-1 family members interact with innate immunity cells promoting innate immunity, as well as with innate and adaptive lymphoid cells, contributing to their differentiation and functional polarization and plasticity. Here we will review the properties of two key regulatory receptors of the IL-1 system, IL-1R2, the first decoy receptor identified, and IL-1R8, a pleiotropic regulator of different IL-1 family members and co-receptor for IL-37, the anti-inflammatory member of the IL-1 family. Their complex impact in pathology, ranging from infections and inflammatory responses, to cancer and neurologic disorders, as well as clinical implications and potential therapeutic exploitation will be presented.

show abstract

Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts

Cited by 37 publications

References 67 publications

A novel bi-directional heterogeneous network selection method for disease and microbial association prediction

A novel bi-directional heterogeneous network selection method for disease and microbial association prediction

Short‐term treatment with zingerone ameliorates dextran sulfate sodium‐induced mouse experimental colitis

Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease

Contact Info

Product

Resources

About