Ulcerative Colitis Complicated by Colonic Lymphoma

Sataline, Lee; Mobley, Evelyn M.; Kirkham, W. W.

doi:10.1016/s0016-5085(63)80146-8

Cited by 29 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cornes and colleagues suggested a significant relationship between repeated episodes of lymphoid hyperplasia seen in the healing phases of UC and the eventual development of NHL 25. The “autoimmune” nature of IBD has also been implicated with the suggestion that lymphoma develops as a result of prolonged stimulation of mucosa associated lymphoid tissue 26. This “autoimmunity” theory may also explain the 2–3-fold increased risk of NHL in rheumatoid arthritis patients who do not receive immunosuppressive therapy 27…”

Section: Discussionmentioning

confidence: 99%

Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

Farrell

Ang

Kileen

et al. 2000

Gut

246

142

View full text Add to dashboard Cite

Background-There is concern that the incidence of non-Hodgkin's lymphoma (NHL) will rise with increasing use of immunosuppressive therapy. Aims-Our aim was to determine the risk of NHL in a large cohort of patients with inflammatory bowel disease (IBD), and to study the association between IBD, NHL, and immunosuppressive therapy. Methods-We studied 782 IBD patients (238 of whom received immunosuppressive therapy) who attended our medical centre between 1990 and 1999 (median follow up 8.0 years). Standardised incidence ratios (SIRs) and 95% confidence intervals (CI) were calculated. Expected cases were derived from 1995 age and sex specific incidence rates recorded by the National Cancer Registry of Ireland. Results-There were four cases of NHL in our IBD cohort (SIR 31.2; 95% CI 2.0-85; p=0.0001), all of whom had received immunosuppressive therapy: azathioprine (n=2), methotrexate (n=1), and methotrexate and cyclosporin (n=1). Our immunosuppressive group had a significantly (59 times) higher risk of NHL compared with that expected in the general population (p=0.0001). Three cases were intestinal NHL and one was mesenteric. Mean age at NHL diagnosis was 49 years, mean duration of IBD at the time of NHL diagnosis was 3.1 years, and mean duration between initiation of immunosuppressive therapy and diagnosis of NHL was 20 months. Conclusions-Although underlying IBD may be a causal factor in the development of intestinal NHL, our experience suggests that immunosuppressive drugs can significantly increase the risk of NHL in IBD. This must be weighed against the improved quality of life and clinical benefit immunosuppressive therapy provides for IBD patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

Farrell

Ang

Kileen

et al. 2000

Gut

246

142

View full text Add to dashboard Cite

show abstract

“…The superimposed lymphoid tumour is usually unicentric. However, one of our cases had two separate lymphoid tumours, as did the cases of Cornes et al (1961) and Sataline et al (1963). Two further cases (Warren, 1959;Nugent et al, 1972) also had two separate malignancies, each having a lymphoma accompanied by a carcinoma.…”

Section: Discussionmentioning

confidence: 50%

Colonic lymphoma complicating ulcerative colitis

Renton

Blackshaw

1976

Journal of British Surgery

View full text Add to dashboard Cite

Colonic lymphoma is a rare complication of ulcerative colitis. Two cases are described in patients who had had ulcerative colitis for 12 and 22 years respectively. Both patients presented with a recent change in their symptoms, which had become increasingly severe and which had not remitted with customary treatment for ulcerative colitis. Physical and haematological examinations revealed no evidence of generalized lymphoma, though barium enema studies indicated the sites of the lymphomatous lesions superimposed on chronic ulcerative colitis which were confirmed at operation and biopsy.

show abstract