Ulcerative Colitis in a Sigmoid Neovagina

Immunoreactivity against goblet cells in patients with inflammatory bowel disease

“…18 Reports of UC occurring after reconstructive surgery of sigmoid neovaginas, where no intestinal bacteria or alimentary antigens are present, suggest that direct exposure to alimentary antigens or intestinal bacterial flora is not always necessary to trigger mucosal inflammation. 19,20 This observation supports there being an autoimmune mechanism. Perinuclear antineutrophil cytoplasmic antibody (pANCA) and antitropomyosin antibodies as well as autoantibodies against heat-shock proteins, epithelial cells, and goblet cells have been described.…”

Ulcerative colitis of the neovagina as a postsurgical complication of persistent cloaca

“…To our knowledge, there have been only 4 other case reports of systemic IBD affecting a sigmoid neovagina: 3 affecting adults [13][14][15] and 1 affecting a pediatric patient [12]. This is the first reported case of UC in a patient status after sigmoid/descending vaginoplasty for persistent cloaca.…”

Ulcerative Colitis in Colonic Interposition for Esophageal Atresia

“…While Crohn’s disease is also a possibility, ulcerative colitis was considered to be more likely than Crohn’s disease given the lack of extracolonic findings (considering colonic conduit is still colonic tissue histologically with normal rest of the upper gastrointestinal tract on EGD and normal ileum on colonoscopy), the endoscopic appearance of the ulcerations, and the lack of granulomas with normal muscularis mucosa on histology. There have been case reports of ulcerative colitis developing in colonic transpositions for vaginal reconstruction,9-11 but to the authors’ knowledge, there has been no published literature on inflammatory bowel disease in colonic conduits for esophageal atresia.…”