Ulcerative colitis with gastric and duodenal involvement

Gavilán, María del Carmen García; Vega, María Carmen López; Sánchez, I.M. Méndez

doi:10.17235/reed.2017.4685/2016

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…Pathologic examination of UC reveals that the lesions are limited to the mucosal layer with Paneth cell metaplasia, mucin depletion, distortion of crypt architecture, crypt abscesses, and infiltrates of the mucosa with inflammatory cells. It is noticeable that the gastroduodenal lesions in the present case possessed similar pathological features with the colorectal lesion, which is consistent with the previous reports[ 3 , 9 - 11 ]. Furthermore, Hisabe et al[ 3 ] proposed diagnostic criteria for GDUC: (1) Improvement of the lesions with treatment of UC; and/or (2) Resemblance of the lesions to UC in pathological findings.…”

Section: Discussionsupporting

confidence: 93%

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Gastroduodenitis associated with ulcerative colitis: A case report

Yang

Chen

et al. 2020

WJCC

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BACKGROUND Ulcerative colitis (UC) is defined as a chronic inflammatory bowel disease that can occur in any part of the large bowel. In addition, UC affects only the large bowel except for backwash ileitis and pouchitis, whereas Crohn's disease (CD) affects the entire digestive tract. Inflammatory bowel disease (IBD) patients tend to be diagnosed with CD or indeterminate colitis when combined with gastric lesion. However, in recent years, some UC patients are reported to have various degrees of lesions in gastroduodenum. Here, we report a case of gastroduodenitis associated with UC (GDUC). CASE SUMMARY A 25-year-old man with a history of Klippel-Trenaunay syndrome presented to the hospital with mucopurulent bloody stool and epigastric persistent colic pain for 2 wk. Continuous superficial ulcers and spontaneous bleeding were observed under colonoscopy. Subsequent gastroscopy revealed mucosa with diffuse edema, ulcers, errhysis, and granular and friable changes in the stomach and duodenal bulb, which were similar to the appearance of the rectum. After ruling out other possibilities according to a series of examinations, a diagnosis of GDUC was considered. The patient hesitated about intravenous corticosteroids, so he received a standardized treatment with pentasa of 3.2 g/d. After 0.5 mo of treatment, the patient’s symptoms achieved complete remission. Follow-up endoscopy and imaging findings showed no evidence of recurrence for 26 mo. CONCLUSION The occurrence of gastrointestinal involvement in UC is rare, which may open a new window for studying the etiology and pathogenesis of UC. Physicians should consider broad differential diagnosis by endoscopic biopsy and laboratory examinations.

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Section: Discussionsupporting

confidence: 93%

“…The concept of GDUC was first proposed by Hori et al[ 10 ], but the diagnosis standard is not rigorous enough due to the scanty reports. More extensive colitis and a lower dose of prednisolone administration might be the main risk factors for GDUC[ 9 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Gastroduodenitis associated with ulcerative colitis: A case report

Yang

Chen

et al. 2020

WJCC

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“…The last decade has brought more and more information about the changes in the stomach and duodenum accompanying ulcerative colitis. The use of a mesalazine preparation in which a part of the active ingredient is released in the stomach may favorably influence the course of treatment of complex inflammatory lesions within GT [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. The latest scientific articles link the inflammatory lesions in the duodenum or stomach with bowel inflammation [ 39 ], which suggests the regions of drug targeting.…”

Section: Resultsmentioning

confidence: 99%

The Influence of the Hydrophobic Polymeric Coating on 5-ASA Release from the Bipolymeric Milibeads with Amidated Pectin

2021

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The industrial polymeric carriers for peroral mesalazine application exploit, i.a., cellulose or polyacrylic acid derivatives, polyvinylpyrrolidone, and modified starch. Pectins, as natural polymers, are interesting materials in pharmaceutical applications due to properties such as non-toxicity, biocompatibility, and biodegradability. The aim of the study was the evaluation of the release of the drug from coated pectin beads doped with synthetic polymers as drug carriers to the colon, as well as interactions between ingredients. The drug release was carried out using basket apparatus. The amount of 5-ASA (5-aminosalicylic acid, mesalazine) released to the pH = 7.4 buffer with pectinase was measured at selected time intervals using UV-Vis spectroscopy. The zero-, first-, and second-order kinetics, as well as Higuchi, Korsmeyer–Peppas, and Hixon–Crowell equations, were used to analyze the release pattern. The interactions between beads components were investigated employing FTIR spectrophotometry and DSC study. The dissolution of the drug was divided into two parts. It was found that the release of 5-ASA followed mainly the Higuchi equation. The mass transport in the first stage of the release followed a non-Fickian model and the parameter n was in the range of 0.74 ± 0.2–0.99 ± 0.2. The formulation doped with PA (polyacrylic acid) was the most appropriate and capable of overcoming the variable conditions of the gastrointestinal tract.

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“…Although the etiology of GDUC is unclear, several studies have revealed that it may be associated with the imbalance of immune response of genetically susceptible hosts to bacterial antigens, resulting in an excessive autoimmune response to the gastroduodenal epithelium [ 10 ]. The diagnostic criteria are lesions that do not respond to standard treatment for ulcers, such as H2 blockers and proton pump inhibitors, and lesions that are sensitive to medication used to treat UC, such as steroids and mesalazine [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Gastroduodenal Ulcerative Colitis in Association with Ulcerative Pancolitis

Aye

Htun

Win

et al. 2021

Case Reports in Gastrointestinal Medicine

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Ulcerative colitis (UC) is a chronic inflammatory bowel disease, traditionally regarded as being limited to the colorectum. Although several gastroduodenal lesions have been reported in cases of UC, in general, duodenal lesions in UC are believed to be uncommon and gastric lesions in UC are a rare presentation. In this report, we presented a 66-year-old lady with upper GI presentation with gastroduodenal ulcerative colitis accompanying pancolonic UC.

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Ulcerative colitis with gastric and duodenal involvement

Cited by 6 publications

References 5 publications

Gastroduodenitis associated with ulcerative colitis: A case report

Gastroduodenitis associated with ulcerative colitis: A case report

The Influence of the Hydrophobic Polymeric Coating on 5-ASA Release from the Bipolymeric Milibeads with Amidated Pectin

Gastroduodenal Ulcerative Colitis in Association with Ulcerative Pancolitis

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