Ulcerative colitis with Guillain–Barré syndrome

Liu, Zhengru; Zhou, Ke; Tian, Shuxin; Dong, Weiguo

doi:10.1097/md.0000000000011013

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…The association between UC and GBS is well documented, although it is not well understood why UC patients are at increased risk of developing GBS (6)(7)(8). The onset of GBS in this case report was characterized by lower extremity weakness and numbness of the upper extremities, which is consistent with the typical symptoms of GBS.…”

Section: Discussionsupporting

confidence: 69%

Guillain-Barré syndrome in remission of Ulcerative colitis: a case report

Khodkam

Panahi

2023

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This case report provides a unique instance of a patient who developed Guillain-Barré syndrome (GBS) during the remission phase of ulcerative colitis (UC). GBS is a rare but severe autoimmune disorder affecting the peripheral nervous system, while UC is a chronic inflammatory bowel disease. The co-occurrence of GBS and UC is rare, and its underlying mechanisms are not well understood. The patient's medical history and the course of their treatment are discussed in detail to provide a comprehensive understanding of the condition. The onset of GBS in this case report was characterized by lower extremity weakness and numbness of the upper extremities, which is consistent with the typical symptoms of GBS. The electromyography (EMG) results showed low limb nerve conduction and velocity with low amplitude, which supports the diagnosis of GBS. The treatment involved intravenous (IV) methylprednisolone, which is a commonly used steroid in the management of GBS. The patient showed improvement in his symptoms, with the weakness and numbness disappearing and muscle strength recovering, which is in line with the expected outcome of treatment with steroids. This case report provides valuable insight into the complex interplay between GBS and UC, and the potential impact of autoimmune diseases on each other. The findings of this report will contribute to the existing literature on GBS and UC, and help healthcare professionals to make informed decisions regarding the diagnosis and management of these complex conditions. The report concludes with a discussion of the implications of the case and the need for further research to better understand the relationship between GBS and UC.

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Section: Discussionsupporting

confidence: 69%

Guillain-Barré syndrome in remission of Ulcerative colitis: a case report

Khodkam

Panahi

2023

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“…Guillain–Barré Syndrome is one form of neurological manifestations which can occur both in remission or a relapse of Ulcerative Colitis[ 10 ]. The exact pathogenesis of Ulcerative Colitis with Guillain–Barré Syndrome is unclear.It may be related to the following factors: Ulcerative Colitis-associated vasculitis, post infection immunity, malnutrition, toxic metabolites, vitamin deficiency, and thrombotic disease[ 11 ]. It is also postulated that since both Ulcerative Colitis and Guillain–Barré Syndrome are autoimmune diseases there may be similar autoimmune mechanisms in the development of both these diseases.…”

Section: Discussionmentioning

confidence: 99%

Concomitant Guillain–Barré Syndrome in a young Sri Lankan male with severe ulcerative colitis

et al. 2022

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Background Guillain–Barré Syndrome is an immune mediated polyneuropathy. Ulcerative Colitis is an immune mediated chronic inflammatory condition mainly of the large intestine. Guillain–Barré Syndrome can present as a rare extraintestinal manifestation of Ulcerative Colitis when in remission or in a relapse. However, the concomitant presentation of Guillain–Barré Syndrome during a relapse of Ulcerative Colitis is very rare and only a few cases are reported to date. Case presentation A 24 year old young male diagnosed of Ulcerative Colitis presented with bloody diarrhea of frequency more than six times a day. He had been in clinical remission even after defaulting treatment for more than a year. He had also noted difficulty in walking prior to admission to the hospital. He was managed as for a severe relapse of Ulcerative Colitis and Guillain–Barré Syndrome. Appropriate management of both the illnesses helped him to recover. Conclusion Immune mediated diseases can have rare coexisting presentations. We report a case of Ulcerative Colitis with concomitant Guillain–Barré Syndrome. It is essential to be open minded and timely, appropriate treatment led to successful management of both the illnesses.

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“…The culture of brucellosis and the detection of specific antibodies in the cerebrospinal fluid is the direct or indirect evidence for the diagnosis of neurobrucellosis [ 3 , 4 ]. Guillain–Barre syndrome (GBS) is an immune-mediated peripheral neuropathy that is often induced by viruses and Campylobacter jejuni [ 5 ]. The primary lesion is a segmental demyelination of motor and sensory nerves in multiple nerve roots and peripheral nerves, however, brucella-induced GBS is very rare.…”

Section: Introductionmentioning

confidence: 99%

A case of brucellosis-induced Guillain–Barre syndrome

Liu

Jiang

et al. 2022

BMC Infect Dis

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Background Guillain–Barre syndrome (GBS) is a rare neurological complication of brucellosis, and neurobrucellosis is the most common, but they have many similarities in clinical manifestations. Many clinicians are accustomed to merely explaining the manifestations of nervous system involvement with neurobrucellosis, but they ignore the possibility of GBS, and this leads to misdiagnosis, untimely treatment, and serious consequences. Case presentation A 55-year-old male patient was admitted to The First Affiliated Hospital of Harbin Medical University for intermittent fever, fatigue, and waist pain more than three months. Brucellosis was diagnosed from the blood test. Although anti-brucella treatment was given at the time of diagnosis, the disease continued to progress. At the time of the cerebrospinal fluid systematic physical examination and the neuroelectrophysiological test, acute motor sensory axonal neuropathy was diagnosed. The patient was given immediately administered immunoglobulin therapy. After three months of systemic treatment, the patient's muscle strength of the distal limbs gradually recovered. The numbness of the limbs eased slowly, and urination function and respiratory function returned to normal. He could sit by himself. Conclusions The possibility of GBS should be closely monitored for when a brucellosis patient shows typical clinical manifestations of progressive muscle weakness, protein-cell separation of the cerebral spinal fluid, and typical demyelinating sensorimotor polyneuropathy.

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Ulcerative colitis with Guillain–Barré syndrome

Cited by 8 publications

References 10 publications

Guillain-Barré syndrome in remission of Ulcerative colitis: a case report

Guillain-Barré syndrome in remission of Ulcerative colitis: a case report

Concomitant Guillain–Barré Syndrome in a young Sri Lankan male with severe ulcerative colitis

A case of brucellosis-induced Guillain–Barre syndrome

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