Ulcerative Eosinophilic Granuloma of the Tongue: A Light- and Electron-microscopic Study

Tang, Thomas T.; Glicklich, Marvin; Hodach, Albertina E.; Oechler, Herbert W.; McCreadie, Samuel R.

doi:10.1093/ajcp/75.3.420

Cited by 39 publications

(20 citation statements)

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“…As this disorder is of great interest for several medical specialties, such as dermatologists, otolaryngologists and dentists, various daunting terms have been used to characterize this disorder. These include, ulcerated granuloma eosinophilicum diutinum of the tongue [1], a term that has been abandoned, EU [2,3,4,5,6], traumatic granuloma [7,8], eosinophilic granuloma [9,10], traumatic eosinophilic granuloma [11,12], ulcerative eosinophilic granuloma [13,14], traumatic ulcerative granuloma with stromal eosinophilia [15,16], traumatic eosinophilic ulcer [17,18], and a combination of these. Adding to this list, identical clinical features exclusively seen in nursing infants are known as Riga-Fede disease [19].…”

Section: Introductionmentioning

confidence: 99%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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Eosinophilic ulcer of the oral mucosa is a benign lesion of unclear pathogenesis mostly affecting the tongue. It has been suggested to represent a reactive pattern to several stimuli. We report on a 12-year-old boy who presented with a painless infiltrating ulcer on the gingiva of the lower jaw, which was covered by necrotic yellowish slough. There were no pathologic features of the jawbones or regional lymph nodes. Histopathological, immunohistochemical and gene rearrangement studies were in agreement with eosinophilic ulcer with predominant oligoclonal CD3+ and CD30+ T lymphocytes expressing the Epstein-Barr virus membrane protein. The ulcer resolved within 4 weeks and follow-up for 3 years revealed no evidence of recurrence. Epstein-Barr virus may have played a role in triggering this reactive lymphoproliferative disorder.

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Section: Introductionmentioning

confidence: 99%

Oral Eosinophilic Ulcer, an Epstein-Barr Virus-Associated CD30+ Lymphoproliferation?

Abdel-Naser¹,

Tsatsou²,

Hippe³

et al. 2011

Dermatology

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“…However, according to Goho 20 the most appropriate descriptive term is sublingual neonatal traumatic ulcer. Tang et al 21 proposed that viral and toxic agents introduced to the submucosa, by means of trauma and mucosal damage, can cause inflammatory reaction and tissue loss.…”

Section: Discussionmentioning

confidence: 99%

Natal teeth associated with Riga-Fede ulcer: case report

Danelon¹,

Emerenciano²,

Garcia³

et al. 2017

Arch Health Invest

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Aim: Was to report a case report showing the occurrence of natal teeth associated with Riga-Fede ulcer, clinical implications and treatment approach. Case report: Two-month-old female patient, was taken by his mother to the Baby Clinic of the Araçatuba Dental School, Univ. Estadual Paulista (UNESP) -Department of Pediatric Dentistry and Public Health-Brazil, reporting ulcer in the womb of tongue and weight loss. On clinical examination, there was teeth in the region of the mandibular incisors and in the ventral region of the tongue, characterized as Riga-Fede ulcer. In the radiographic examination it was noted that the same was supernumerary. After clinical and radiographic examinations, we opted for the natal teeth exodontics. After thirty days, the mother informed us that the ulcer disappeared and the child returned to feed, demonstrating that the approach has proved suitable and effective. Conclusions: Natal teeth supernumerary when related the Riga-Fede ulcer should be extracted; It should not be neglect weight loss in infants and treatment aims at healing of the lesion feed return and weight gain. Descriptors: Natal Teeth; Oral Ulcer; Tongue Diseases. ResumoObjetivo: Relatar um relato de caso mostrando a ocorrência de dentes natais associados à úlcera de Riga-Fede, implicações clínicas e abordagem terapêutica. Relato de caso: Paciente do sexo feminino de dois meses de idade, foi levado pela mãe à Bebê Clínica da Faculdade de Odontologia de Araçatuba, Univ. Estadual Paulista (UNESP) -Departamento de Odontologia Infantil e Social-Brasil, relatando úlcera no ventre da língua e perda de peso. No exame clínico, havia dentes na região dos incisivos mandibulares e úlcera na região ventral da língua, caracterizada como úlcera de Riga-Fede. Ao exame radiográfico observou-se que o mesmo era supranumerário. Após exames clínicos e radiográficos, optou-se pela exodontia dos dentes natais. Após trinta dias, a mãe informou que a úlcera desapareceu e a criança voltou a alimentar-se, demonstrando que a abordagem mostrou-se adequada e eficaz. Conclusões: Os dentes Natais supranumerários quando relacionados a úlcera de Riga-Fede devem ser extraídos; Não deve ser negligenciado a perda de peso em lactentes e o tratamento visa a cicatrização da lesão e ganho de peso. Descritores: Dentes Natais; Úlceras Orais; Doenças da Língua. ResumenObjetivo: Informar un caso que muestre la ocurrencia de los dientes natales asociados con la úlcera de Riga-Fede, las implicaciones clínicas y el enfoque del tratamiento. Caso clínico: Paciente de dos meses de edad, fue llevada por su madre a la Clínica del Bebé de la Escuela Odontológica de Araçatuba, Univ. Estadual Paulista (UNESP) -Departamento de Odontología Pediátrica y Salud Pública-Brasil, reportando úlcera en el vientre de la lengua y pérdida de peso. En el examen clínico, hubo dientes en la región de los incisivos mandibulares y en la región ventral de la lengua, caracterizada como úlcera de Riga-Fede. En el examen radiográfico se observó que el mismo era supernumerario. Después de...

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“…Das ulzeröse eosinophile Granulom der Zunge stellt eine seltene benigne Erkrankung dar [1,2]. Als Synonym wird u. a. der Begriff traumatisches ulzeröses Granulom mit Stromaeosinophilie verwendet.…”

Section: ✜ Ulzeröses Eosinophiles Granulom Der Zungeunclassified

“…In der Regel stellt eine Inzisionsbiopsie bzw. umschriebene Exzision eine suffiziente Therapie dar [4], jedoch werden auch rezidivierende [5] und nicht rezidivierende Spontanheilungen beschrieben [1,2]. Morphologisch müssen ein malignes Lymphom und ein Karzinom ausgeschlossen werden.…”

Section: ✜ Ulzeröses Eosinophiles Granulom Der Zungeunclassified