Ulcerative Keratitis in Contact Lens Wearers Incidence and Risk Factors

Schein, Oliver D.; Poggio, Eugene C.

doi:10.1097/00003226-199010001-00023

Cited by 33 publications

(26 citation statements)

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“…The overnight wear of extended wear lenses increased the risk of ulcerative keratitis, 90 with the possibility of conjunctival cytologic changes. 71,75,76 Schein et al 76 mainly attributed the high risk of microbial keratitis among the users of extended wear lenses to the overnight wear, rather than to lens hygiene or lens type.…”

Section: Overnight Sleep In Different Types Of Contact Lensesmentioning

confidence: 99%

How Could Contact Lens Wearers Be at Risk of Acanthamoeba Infection? A Review

Ibrahim

Boase

Cree

2009

Journal of Optometry

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Contact lens wear is highly influential on the incidence of ulcerative keratitis worldwide, particularly in developed countries. The association between Acanthamoeba keratitis and contact lens wear is firmly established; it may account for up to 95% of the reported cases. Before the popularisation of soft contact lens wear, Acanthamoeba keratitis was extremely rare. In 2000 it was estimated that the number of contact lens wearers worldwide was about 80 million, out of whom 33 million were in the United States and 90% of them wore hydrogel soft lenses. Contact lens-related problems depend on many factors, such as lens material, wearing modality, lens hygiene, type of lens-caring solution, the degree of compliance of the lens user with lens wear and care procedures, lens overwear, sleeping in lenses, rate of changing lenses, and lens case hygiene. This paper is a thorough review of the literature aiming to highlight the role of one of the main risk factors of infectious keratitis, contact lens wear, and also to show the responsibility of lens users in aggravating this risk. RESUMENLa utilización de lentes de contacto es un factor que influye sumamente en la incidencia de la queratitis ulcerosa, en particular en los países desarrollados. La asociación entre queratitis por Acanthamoeba y el uso de lentes de contacto está firmemente establecida; podría representar aproximadamente hasta un 95% de los casos registrados. Antes de la popularización del uso de lentes de contacto, la queratitis por Acanthamoeba era muy poco frecuente. En el año 2000 se estimó que, a nivel mundial, había unos 80 millones de usuarios de lentes de contacto, de los cuales 33 millones residían en los Estados Unidos y, de ellos, el 90% utilizaban lentes de contacto blandas de hidrogel. Los problemas derivados del uso de lentes de contacto dependen de otros muchos factores, como el material del que está hecha la lente, la modalidad de uso, las medidas de higiene empleadas, el tipo de solución utilizada para la limpieza y el mantenimiento de la lente, el grado de cumplimiento terapéutico del usuario de las lentes respecto a su utilización y a su limpieza/mantenimiento, el uso de las lentes durante periodos excesivamente prolongados, el dormir con las lentes de contacto puestas, la frecuencia con la que el usuario se cambia de lentes y la limpieza de la funda de las lentes de contacto. Este artículo presenta una revisión minuciosa de la literatura, con el objetivo de resaltar el papel de uno de los principales factores de riesgo de desarrollo de queratitis infeccionsa, como es el uso de lentes de contacto, y con el fin de poner de relieve que el propio usuario de las lentes es, en ocasiones, el responsable de agravar este riesgo. (J Optom 2009;2:60-66 ©2009 Consejo General de Colegios de Ópticos-Optometristas de España) PALABRAS CLAVE: Acanthamoeba; queratitis; lentes de contacto; usuario de lentes de contacto; uso excesivo de las lentes de contacto.

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Section: Overnight Sleep In Different Types Of Contact Lensesmentioning

confidence: 99%

How Could Contact Lens Wearers Be at Risk of Acanthamoeba Infection? A Review

Ibrahim

Boase

Cree

2009

Journal of Optometry

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“…Myopia has also been implicated in a number of potentially blinding eye conditions including: peripheral retinal abnormalities (Pierro et al 1992), age related cataracts (Lim et al 1999;Leske et al 2002), glaucoma , myopic retinal degeneration (Vongphanit et al 2002), and choroidal neovascularization (Cohen et al 1996). Furthermore, common modes of refractive correction such as contact lenses or refractive surgery can lead to adverse effects (Schein and Poggio 1990;Stulting et al 1999). …”

Section: Introductionmentioning

confidence: 99%

Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36

et al. 2006

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The development of refractive error is mediated by both environmental and genetic factors. We performed regression-based quantitative trait locus (QTL) linkage analysis on Ashkenazi Jewish families to identify regions in the genome responsible for ocular refraction. We measured refractive error on individuals in 49 multi-generational American families of Ashkenazi Jewish descent. The average family size was 11.1 individuals and was composed of 2.7 generations. Recruitment criteria specified that each family contain at least two myopic members. The mean spherical equivalent refractive error in the sample was −3.46D (SD=3.29) and 87% of individuals were myopic. Microsatellite genotyping with 387 markers was performed on 411 individuals. We performed multipoint regression-based linkage analysis for ocular refraction and a log transformation of the trait using the statistical package Merlin-Regress. Empirical genomewide significance levels were estimated through gene-dropping simulations by generating random genotypes at each of the 387 markers in 200 replicates of our pedigrees. Maximum LOD scores of 9.5 for ocular refraction and 8.7 for log-transformed refraction (LTR) were observed at 49.1 cM on chromosome 1p36 between markers D1S552 and D1S1622. The empirical genomewide significance levels were P=0.065 for ocular refraction and P<0.005 for LTR, providing strong evidence for linkage of refraction to this locus. The inter-marker region containing the peak spans 11 Mb and contains approximately 189 genes. Conclusion: We found genomewide significant NIH Public Access

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“…[16][17][18][19][20][21][22][23] For example, only 53% to 77% contact lens wearers wash their hands before handling their lenses [17][18][19]24,25 and approximately 6% report unauthorized overnight wear of lenses, 17,[26][27][28][29] despite the increased risk for contact lens contamination, microbial keratitis and corneal infiltrates, respectively. [30][31][32][33][34][35][36][37][38][39][40][41][42] Violations of prescribed regimens for replacement of lens and lens care components are currently widespread. For instance, 40% to 74% contact lens wearers do not replace lenses per the manufacturer's recommended replacement schedule (MRRP), 17,26-29 despite anecdotal and scientific reports of compromises in vision, comfort, contact lens complications, and moderate-to-severe corneal staining with use of lenses beyond their MRRP.…”

mentioning

confidence: 99%