Ulcers of the Leg in Cooley's Anemia

Stiffness of the Abdominal Aorta in β-Thalassemia Major Patients Related With Body Iron Load

“…Some of the important clinical features of thalassemias include vascular disorders, such as thromboembolic complications including pulmonary thromboembolism, pulmonary hypertension, leg ulcers, and cerebrovascular events. [29][30][31][32][33] Consistent with the pathogenesis of such events, the data indicate that injury of vascular endothelial cells is present in thalassemia patients. 34,35 In vitro studies detected disturbances of human vascular endothelial cell function, when the cell culture was incubated with thalassemic serum.…”

A randomized phase II trial of Arginine Butyrate with standard local therapy in refractory sickle cell leg ulcers

“…Emerging evidence indicates that leg ulceration is probably linked with hyperhaemolytic phenotypes of this disease (Steinberg, 2005; Kato et al , 2007). Other conditions with chronic haemolysis, such as β‐thalassaemia, are also associated with refractory leg ulcers (Pascher & Keen, 1957; Pope & Hodgson, 1968; Taher et al , 2010). Recent studies to elucidate genetic modifiers have identified an association between single nucleotide polymorphism (SNPs) in or near the KL gene and the occurrence of leg ulcers (Nolan et al , 2006).…”

The reduction of cholesteryl linoleate in lipoproteins: an index of clinical severity in β-thalassemia/Hb E

“…Therefore, oxidative stress has been considered an important mechanism in the development of various clinical complications in b-thalassemia. Among the complications, atherogenesis-related vascular complications such as pulmonary thromboembolism, cerebral thrombosis and chronic leg ulcers are commonly found (2)(3)(4)(5). The oxidative modification of plasma lipoproteins has been suggested to play a crucial role in atherogenesis-related vascular alterations in thalassemia (6)(7)(8)(9).…”