Ulcers of the Leg in Mediterranean Disease

Abstract

Ulceration of the skin of the legs may occur in Mediterranean disease. Such ulceration cannot be distinguished grossly from that occurring in sickle cell anemia and congenital hemolytic icterus. The outstanding histologic feature (noted at biopsy of one of these ulcers) is the prominent deposition of iron in the cutis.

Sex Differences in Bilateral Leg Ulcers in Thalassemia Minor

“…There are few reports of leg ulcers in association with thalassemia minor, usually because the underlying cause cannot be identified. Most reported cases occurred in women 1–3,5 of Italian descent with unilateral or bilateral malleolar ulcers; mean age at onset in these cases was 25.6 years; range, 14 to 44 years, and hemoglobin level was 6.3–10 g/dL.…”

“…They have rarely been reported in thalassemia minor (Table). 1–6 While both sexes are equally affected with thalassemia, there is a female predominance in cases with associated leg ulcers. We describe a case in which ulcus cruris developed in a woman with thalassemia, and we present an explanation for the difference in incidence between men and women.…”

Racing Performance of the Quarter Horse: Genetic Parameters, Trends and Correlation for Earnings, Best Time and Time Class

“…The use of earnings as a trait in horses was first reported in 1948 [8], who called it the Average Earnings Index. This trait was altered in 1977 [9] and named the Standard Starts Index.…”