Ulinastatin ameliorated streptozotocin-induced diabetic nephropathy: Potential effects via modulating the components of gut-kidney axis and restoring mitochondrial homeostasis

Rizk, Fatma H; Saadany, Amira A El; Atef, Marwa Mohamed; Abd-Ellatif, Rania; El-Guindy, Dina M.; Ghafar, Muhammad Tarek Abdel; Shalaby, Marwa M.; Hafez, Yasser Mostafa; Mashal, Shaimaa Samir Amin; Basha, Eman; Faheem, Heba Ahmed; Barhoma, Ramez A.

doi:10.1007/s00424-023-02844-6

Cited by 6 publications

(1 citation statement)

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“…Through the gut–kidney axis, gut microbiota can promote DKD through various aspects, such as metabolites and immune responses [ 97 ]. Therefore, treatments targeting the improvement of intestinal flora will also become a major research direction [ 98 ]. Nowadays, there is also a lot of evidence showing the important role of organelles in DKD [ 99 ].…”

Section: Therapeutic Options Targeting Mitochondrial Dysfunction In D...mentioning

confidence: 99%

Roles of Mitochondrial Dysfunction in Diabetic Kidney Disease: New Perspectives from Mechanism to Therapy

Yang,

Liu,

Shi

et al. 2024

Biomolecules

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Diabetic kidney disease (DKD) is a common microvascular complication of diabetes and the main cause of end-stage renal disease around the world. Mitochondria are the main organelles responsible for producing energy in cells and are closely involved in maintaining normal organ function. Studies have found that a high-sugar environment can damage glomeruli and tubules and trigger mitochondrial dysfunction. Meanwhile, animal experiments have shown that DKD symptoms are alleviated when mitochondrial damage is targeted, suggesting that mitochondrial dysfunction is inextricably linked to the development of DKD. This article describes the mechanisms of mitochondrial dysfunction and the progression and onset of DKD. The relationship between DKD and mitochondrial dysfunction is discussed. At the same time, the progress of DKD treatment targeting mitochondrial dysfunction is summarized. We hope to provide new insights into the progress and treatment of DKD.

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Section: Therapeutic Options Targeting Mitochondrial Dysfunction In D...mentioning

confidence: 99%