Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Kang, Moon Seong; Yumnam, Silvia; Park, Woo Sung; So, Hae Min; Kim, Ki‐Hyun; Shin, Meong Cheol; Ahn, Mi‐Jeong; Kim, Sun Yeou

doi:10.3390/jcm9010059

Cited by 15 publications

(9 citation statements)

References 30 publications

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“…The stem or root bark has been traditionally used for inflammation and gastric diseases 13 . Recent studies have shown antioxidant, anti-inflammatory, and skin wound healing effects of Ulmus parvifolia 14 , 15 . Catechin-7- O -α-L-rhamnopyranoside (C7R), a catechin glycoside has been isolated as a major component from the stem bark of Ulmus parvifolia .…”

Section: Introductionmentioning

confidence: 99%

Catechin-7-O-α-L-rhamnopyranoside can reduce α-MSH-induced melanogenesis in B16F10 melanoma cells through competitive inhibition of tyrosinase

Hwang¹,

Lee²,

Park³

et al. 2022

Int. J. Med. Sci.

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Although melanogenesis is a defense mechanism against ultraviolet (UV)-induced skin damage, abnormally excessive melanin production causes pigmentation disorders. Tyrosinase, as a key factor for melanin synthesis, plays an important role in inducing skin pigmentation. Therefore, the inhibition of tyrosinase is crucial in preventing skin pigmentation in the cosmetics and medicine fields. However, the majority of well-known tyrosinase inhibitors have been discontinued due to toxic effects on the skin or lack of selectivity and/or stability. In this study, we evaluated possible anti-melanogenic effects of catechin-7-O-α-L-rhamnopyranoside (C7R) isolated from the stem bark of Ulmus parvifolia, to discover a new tyrosinase inhibitor that has both safety and stability. When C7R was pretreated in B16F10 melanoma cells stimulated by α-melanocyte-stimulating hormone, this compound reduced melanin accumulation and murine tyrosinase activity. In line with these results, C7R inhibits tyrosinase purified from a mushroom in vitro like kojic acid and arbutin. Furthermore, C7R exhibited a competitive inhibition on a Lineweaver-Burk plot. Next, the underlying mechanisms of the C7R-mediated tyrosinase inhibitory effect were sought through docking simulation and pharmacophore analysis between tyrosinase residues and C7R. The results of these analyses showed that C7R had binding energy of -14.5kcal/mol, and indicated that C7R interacts with tyrosinase through an aromatic ring and various hydrophobic and hydrogen bonds. Together, our results suggest that C7R can be applied as a novel natural anti-melanogenic agent that inhibits tyrosinase.

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Section: Introductionmentioning

confidence: 99%

Catechin-7-O-α-L-rhamnopyranoside can reduce α-MSH-induced melanogenesis in B16F10 melanoma cells through competitive inhibition of tyrosinase

Hwang¹,

Lee²,

Park³

et al. 2022

Int. J. Med. Sci.

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“…The bark has the value of demulcent, diuretic, expectorant and febrifuge. 2–4 Additionally, modern medical studies have proved that bark of U. parvifolia have the functions of antioxidant, anti-inflammatory, 5 anti-obesity, 6 anti-platelet, 7 anti-cancer, 8 skin wound healing, 9 and protection of allergic asthma activities. 10 …”

Section: Introductionmentioning

confidence: 99%

Comparison analysis of metabolite profiling in seeds and bark ofUlmus parvifolia, a Chinese medicine species

Yin

Wang³

et al. 2022

Plant Signaling & Behavior

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Ulmus parvifolia ( U. parvifolia ) is a Chinese medicine plant whose bark and leaves are used in the treatment of some diseases such as inflammation, diarrhea and fever. However, metabolic signatures of seeds have not been studied. The seeds and bark of U. parvifolia collected at the seed ripening stage were used for metabolite profiling analysis through the untargeted metabolomics approach. A total of 2,578 and 2,207 metabolites, while 503 and 132 unique metabolites were identified in seeds and bark, respectively. Additionally, 574 differential metabolites (DEMs) were detected in the two different organs of U. parvifolia , which were grouped into 52 classes. Most kinds of metabolites classed into prenol lipids class. The relative content of flavonoids class was the highest. DEMs contained some bioactive compounds (e.g., flavonoids, terpene glycosides, triterpenoids, sesquiterpenoids) with antioxidant, anti-inflammatory, and anti-cancer activities. Most kinds of flavonoids and sesquiterpenes were up-regulated in seeds. There were more varieties of terpene glycosides and triterpenoids showing up-regulated in bark. The pathway enrichment was performed, while flavonoid biosynthesis, flavone and flavonol biosynthesis were worthy of attention. This study identified DEMs with pharmaceutical value between seeds and bark during seed maturation and offered a molecular basis for alternative or complementary use of seeds and bark of U. parvifolia as a Chinese medicinal material.

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“…5 The skin protects against environmental factors such as harmful UV rays and pathogens and prevents water loss. 6 Wound healing is one of the functions of skin. 7 Wound healing maintains homeostasis.…”

Section: Introductionmentioning

confidence: 99%

A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells

et al. 2022

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Background: Wound-healing in the skin is one mechanism that maintains homeostasis. Ineffective skin wound healing is a significant health problem that ultimately causes morbidity and mortality. The process of wound healing using traditional medicine has a good effect with various mechanisms of action. This review aims to provide insights related to the wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method was used from primary and secondary libraries. The library search was conducted using online-based library search instruments from 1988 to 2021, such as NCBI-PubMed, Google Scholar, and Elsevier. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound healing by various mechanisms. Conclusions: Several compounds in plants have shown the activity in wound healing in keratinocyte cells by various mechanisms.

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Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Cited by 15 publications

References 30 publications

Catechin-7-O-α-L-rhamnopyranoside can reduce α-MSH-induced melanogenesis in B16F10 melanoma cells through competitive inhibition of tyrosinase

Catechin-7-O-α-L-rhamnopyranoside can reduce α-MSH-induced melanogenesis in B16F10 melanoma cells through competitive inhibition of tyrosinase

Comparison analysis of metabolite profiling in seeds and bark ofUlmus parvifolia, a Chinese medicine species

A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells

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