Ultra-fast high-efficiency enantioseparations by means of a teicoplanin-based chiral stationary phase made on sub-2μm totally porous silica particles of narrow size distribution

Ismail, Omar H.; Ciogli, Alessia; Villani, Claudio; Martino, Michela De; Pierini, Marco; Cavazzini, Alberto; Bell, David S.

doi:10.1016/j.chroma.2015.11.071

Cited by 81 publications

(54 citation statements)

References 47 publications

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“…Our group participated actively in the transition of chiral HPLC to chiral UHPLC stationary phases. From the first seminal paper in 2010, where a (1R,2R) ‐diaminocyclohexane derivative was chosen as selector for 5 to sub‐2 μm transfer, other selectors have been successfully bonded on FPPs with reduced diameter . It is important to highlight that in the enantioselective HPLC–UHPLC transition, the silica employed should maintain the same physical–chemical behaviors (porosity, surface area, and pore volume) except the dimension of particles.…”

Section: Enantioselective Uhplc By Direct Approachmentioning

confidence: 99%

Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Ciogli

Ismail

Mazzoccanti

et al. 2018

J of Separation Science

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The ever-increasing need for enantiomerically pure chiral compounds has greatly expanded the number of enantioselective separation methods available for the precise and accurate measurements of the enantiomeric purity. The introduction of chiral stationary phases for liquid chromatography in the last decades has revolutionized the routine methods to determine enantiomeric purity of chiral drugs, agrochemicals, fragrances, and in general of organic and organometallic compounds. In recent years, additional efforts have been placed on faster, enantioselective analytical methods capable to fulfill the high throughput requirements of modern screening procedures. Efforts in this field, capitalizing on improved chromatographic particle technology and dedicated instrumentation, have led to highly efficient separations that are routinely completed on the seconds time scale. An overview of the recent achievements in the field of ultra-high-resolution chromatography on column packed with chiral stationary phases, both based on sub-2 μm fully porous and sub-3 μm superficially porous particles, will be given, with an emphasis on very recent studies on ultrafast chiral separations.

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Section: Enantioselective Uhplc By Direct Approachmentioning

confidence: 99%

Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Ciogli

Ismail

Mazzoccanti

et al. 2018

J of Separation Science

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“…It also showed large selectivity for organic/inorganic ions. 205,206 To further speed up chiral separation, Gasparrini et al combined the use of a short column (1 cm length) and…”

Section: Automated Tools For Methods Development In Chromatographymentioning

confidence: 99%

Recent Advances in Chromatography for Pharmaceutical Analysis

et al. 2018

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“…Among the many sustained carriers, mesoporous silica materials with a specific surface structure are capable of gradually releasing various drugs and controlling this process [170]. Mesoporous silica materials are attractive due to their resistance to heat [171], pH [172], resistance to mechanical stress [173], very small pore sizes [174], and have more potential compared with other Nano-carriers in terms of greater accuracy in the selective loading of various drug molecules and their large pore volumes available for drug loading [175]. The use of a silica mesostructure for the purpose of drug delivery was reported in early 1983.…”

Section: Application Of Silica Mesopores In Drug Deliverymentioning

confidence: 99%

Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts

et al. 2020

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The application of silica mesoporous structures in drug delivery and the removal of pollutants and organic compounds through catalytic reactions is increasing due to their unique characteristics, including high loading capacities, tunable pores, large surface areas, sustainability, and so on. This review focuses on very well-studied class of different construction mesoporous silica nano(particles), such as MCM-41, SBA-15, and SBA-16. We discuss the essential parameters involved in the synthesis of these materials with providing a diverse set of examples. In addition, the recent advances in silica mesoporous structures for drug delivery and catalytic applications are presented to fill the existing gap in the literature with providing some promising examples on this topic for the scientists in both industry and academia active in the field. Regarding the catalytic applications, mesoporous silica particles have shown some promises to remove the organic pollutants and to synthesize final products with high yields due to the ease with which their surfaces can be modified with various ligands to create appropriate interactions with target molecules. In the drug delivery process, as nanocarriers, they have also shown very good performance thanks to the easy surface functionalization but also adjustability of their porosities to providing in-vivo and in-vitro cargo delivery at the target site with appropriate rate.

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Ultra-fast high-efficiency enantioseparations by means of a teicoplanin-based chiral stationary phase made on sub-2μm totally porous silica particles of narrow size distribution

Cited by 81 publications

References 47 publications

Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Recent Advances in Chromatography for Pharmaceutical Analysis

Silica Mesoporous Structures: Effective Nanocarriers in Drug Delivery and Nanocatalysts

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