2022
DOI: 10.1002/jssc.202200037
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Ultra‐fast screening of free fatty acids in human plasma using ion mobility mass spectrometry

Abstract: Free fatty acids are involved in many metabolic regulations in the human body. In this work, an ultra‐fast screening method was developed for the analysis of free fatty acids using trapped ion mobility spectrometry coupled with mass spectrometry. Thirty‐three free fatty acids possessing different unsaturation degrees and different carbon chain lengths were baseline separated and characterized within milliseconds. Saturated, monounsaturated, and polyunsaturated free fatty acids showed different linearities betw… Show more

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Cited by 1 publication
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“…But due to the large polarity of FAs, it is difficult to achieve complete separation of SCFAs to LCFAs by LC [29]. Recently, with the development of MS, soft ionization techniques, and high‐sensitivity detectors [30], LC‐MS has become the mainstream means of FAs determination [31]. Nonetheless, the low ionization efficiency of FAs in negative ion mode and the high cost of FAs isotope internal standards (IS) are still problems that need to be solved.…”
Section: Introductionmentioning
confidence: 99%
“…But due to the large polarity of FAs, it is difficult to achieve complete separation of SCFAs to LCFAs by LC [29]. Recently, with the development of MS, soft ionization techniques, and high‐sensitivity detectors [30], LC‐MS has become the mainstream means of FAs determination [31]. Nonetheless, the low ionization efficiency of FAs in negative ion mode and the high cost of FAs isotope internal standards (IS) are still problems that need to be solved.…”
Section: Introductionmentioning
confidence: 99%