Square concrete-filled double steel tubular (CFDST) beam-columns consisting of an internal circular steel tube have increasingly been utilized in composite building structures because of their high structural performance. This paper describes experimental and numerical studies on the structural responses of square thin-walled CFDST columns loaded eccentrically. Tests on twenty short square CFDST columns were undertaken that included sixteen columns under eccentric loading and four columns under concentric loading. The parameters examined in the experiments included the cross-sectional dimensions, the width-to-thickness ratios of outer and internal tubes and loading eccentricity. The measured ultimate strengths, load-shortening responses, load-lateral displacement curves, stress-strain curves and observed failure modes are presented. A numerical model incorporating the fiber analysis is developed that predicts the moment-curvature responses and axial load-moment strength envelopes of CFDST columns.