Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

Shan, Chun; Huang, Yuting; Wei, Jingsong; Chen, Min; Wu, Limin

doi:10.1039/d1ra00213a

Cited by 8 publications

(7 citation statements)

References 46 publications

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“…11 In a recent study by Shan et al, the NIR-laser-regulated gold nanorod, coated with a ultra-thick mesoporous silica assembly, showed an enhanced chemo-photothermal effect. 12 Other studies have also exhibited the improved photothermal response of gold nanocarriers with compatible outer shell coatings. 13 These effective combinational therapies still lack a specific targeting ability toward tumor cells.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The extensive research on GNPs proves that GNPs are chemically inert and biocompatible as they can interact appropriately with their biological environment, i.e., without causing a toxic or immune reaction in the treated biomaterial (cell, tissue, or organism). , GNPs are biocompatible due to their size, shapes, and surface functionalization strategies by which one can directly conjugate proteins, nucleic acids, drugs or dyes, antibodies, and enzymes . In a recent study by Shan et al, the NIR-laser-regulated gold nanorod, coated with a ultra-thick mesoporous silica assembly, showed an enhanced chemo-photothermal effect . Other studies have also exhibited the improved photothermal response of gold nanocarriers with compatible outer shell coatings .…”

Section: Introductionmentioning

confidence: 99%

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Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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The delivery and accumulation of therapeutic drugs into cancer cells without affecting healthy cells are a major challenge for antitumor therapy. Here, we report the synthesis of a liposomal hybrid gold nano-assembly with enhanced photothermal activity for lung cancer treatment. The core components of the nano-assembly include gold nanorods coated with a mesoporous silica shell that offers an excellent drug-loading surface for encapsulation of doxorubicin. To enhance the photothermal capacity of nano-assembly, IR 780 dye was loaded inside a thermo-sensitive liposome, and then, the core nano-assembly was wrapped within the liposome, and GE-11 peptide and folic acid were conjugated onto the surface of the liposome to give the final nano-assembly [(GM@Dox) LI]-PF. The dual targeting approach of [(GM@Dox) LI]-PF leads to enhanced cellular uptake and improves the accumulation of nano-assemblies in cancer cells that overexpress the epidermal growth factor receptor and folate. The exposure of near-infrared laser irradiation can trigger photothermal-induced structural disruption of the nano-assembly, which allows for the precise and controllable release of Dox at targeted sites. Additionally, chemo-photothermal therapy was shown to be 11 times more effective in cancer cell treatment when compared to Dox alone. Our systematic study suggests that the nano-assemblies facilitate the cancer cells undergoing apoptosis via an intrinsic mitochondrial pathway that can be directly triggered by the chemo-photothermal treatment. This study offers an appealing candidate that holds great promise for synergistic cancer treatment.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Patel

Rathnayake

Singh

et al. 2023

ACS Appl. Bio Mater.

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“…[7][8][9] Based on these factors, various nanostructures containing GNRs have recently been vigorously developed in biomedicine. [10][11][12][13][14] Precise and effective PTT need to be supplemented by a clear imaging guidance. [15] The GNR itself has imaging capabilities, namely photoacoustic imaging.…”

Section: Introductionmentioning

confidence: 99%

Obviously Enhanced Fluorescent Signal of Core‐Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

Huang

et al. 2023

Part & Part Syst Charact

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In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core‐shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO2 are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli‐responsive conjugated polymer, polydiacetylene (PDA), and a near‐infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab‐Cy5.5‐GNRs@SiO2 is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV‐3 ovarian cancer cells.

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“…45,50−56 Several attempts including Gorelikov and Matsuura's method require 10 h to 3 days; 31−47,50−56 however, they are limited with poor product yield (∼10 mg) 40 and moderate surface area (∼641 and 934 m 2 /g). 43,44,47,57 Disordered pores and thin silica shells (13−30 nm) 47 significantly reduce the drug loading efficacy of GMS nanoparticles, which is about 25 ± 1.5%. 58 Further, the scalability has always been a bottleneck for such hybrid structures.…”

Section: ■ Introductionmentioning

confidence: 99%

“…B. Tracy and co-workers in more than 20 h . Third, while plain MS (without GNR core) is possible with a surface area of more than 1000 m 2 /g, the highest reported so far are 640 and 934 m 2 /g. , Surface area directly restricts the maximum achievable payload capacity of 25 (±1.5)% reported to date . More importantly, effective encapsulation mechanisms of nanorods in thick MS (more than 30 nm thickness and more than 1000 m 2 /g surface area) with multifunctional theranostics (MFT) response need to be addressed.…”

Section: Introductionmentioning

confidence: 99%

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

Prasad,

Selvaraj

2023

ACS Appl. Mater. Interfaces

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Porous silica coated gold nanorod core−shell structures demonstrate a multifunctional role in bioimaging, drug delivery, and cancer therapeutics applications. Here, we address a new approach for effective distribution of gold nanorods (GNRs) in a mesoporous silica (MS) shell, viz., one nanorod in one silica particle (GMS). We have studied that silica coating presents major advantages for the better biocompatibility and stability of GNRs. In this study, two different thicknesses of silica shell over GNRs have been discussed as per the application's need; GNRs in thin silica (11 nm) are fit for phototherapy and bioimaging, whereas thick and porous silica (51 nm) coated gold nanorods are suitable for triggered drug delivery and theranostics. However, effective distribution of GNRs in ordered architecture of thick mesoporous silica (MS, more than 50 nm thickness) with high surface area (more than 1000 m 2 /g) is not well understood so far. Here, we present methodical investigations for uniform and highly ordered mesoporous silica coating over GNRs with tunable thickness (6 to 51 nm). Judicious identification and optimization of different reaction parameters like concentrations of silica precursor (TEOS, 1.85−43.9 mM), template (CTAB, 0.9−5.7 mM), effect of temperature, pH (8.6−10.8), stirring speed (100−400 rpm), and, most importantly, the mode of addition of TEOS with GNRs have been discussed. Studies with thick, porous silica coated GNRs simplify the highest ever reported surface area (1100 m 2 /g) and cargo capacity (57%) with better product yield (g/batch). First and foremost, we report a highly scalable (more than 500 mL) and rapid direct deposition of an ordered MS shell around GNRs. These engineered core−shell nanoparticles demonstrate X-ray contrast property, synergistic photothermal-chemotherapeutics, and imaging of tumor cell (96% cell death) due to released fluorescent anticancer drug molecules and photothermal effect (52 °C) of embedded GNRs. A deeper insight into their influence on the architectural features and superior theranostics performances has been illustrated in detail. Hence, these findings indicate the potential impact of individual GMS for image guided combination therapeutics of cancer.

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Ultra-high thermally stable gold nanorods/radial mesoporous silica and their application in enhanced chemo-photothermal therapy

Abstract: AuNRs coated with ultra-thick SiO2 shells exhibited ultra-high thermal stability (800 °C), excellent photothermal conversion efficiency (70%) and outstanding loading capacity. The drug release could be nicely controlled by acidity and NIR laser to achieve the “On-demand” mode.

Cited by 8 publications

References 46 publications

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Dual Targeted Delivery of Liposomal Hybrid Gold Nano-Assembly for Enhanced Photothermal Therapy against Lung Carcinomas

Obviously Enhanced Fluorescent Signal of Core‐Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells

Effective Distribution of Gold Nanorods in Ordered Thick Mesoporous Silica: A Choice of Noninvasive Theranostics

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