Ultra-Low Level Detection of L-Histidine Using Solution-Processed ZnO Nanorod on Flexible Substrate

Abstract

This work demonstrates a novel label free and sensitive approach for the detection of L-histidine. This is a simple and reliable method for ultra-low level detection of L-histidine. All solution processed synthesizing technique was utilized to develop such type of detection scheme. Silicon substrate was replaced by normal transparent sheet to make it more facile and cost-effective detection technique. Fabricated device for L-histidine detection works upon the variation of current through the ZnO nanorod with L-histidine concentration. Operation principle strongly depends upon the electron charge transfer between metal cation and L-histidine inside the chelating complex. Morphological, structural and optical characterization of solution processed synthesized ZnO nanorod (ZnO NR) was carried out prior to sensor device fabrication. Our sensor device exhibits the sensitivity around 0.86 nA/fM and lower limit of detection (LOD) ∼ 0.1 fM(S/N=3).

Immobilization of Bovine Serum Albumin Upon Multiwall Carbon Nanotube for High Speed Humidity Sensing Application

“…Easy and reliable drop casting technique was utilized to fabricate humidity sensor. Our fabricated device quickly detects the environmental humidity by the electrical method [28] [29]. The response of the humidity detection was measured in terms of output current or conductance variation with the exposure of different levels of humidity.…”

Recent Advances in Sensing Applications of Molecularly Imprinted Photonic Crystals

“…L-histidine (L-His) is an important composition for brain peptides and of muscle proteins (Nan et al, 1999 ; Rawat and Kailasa, 2014 ). It has been reported that the under-expression or over-expression of L-His may cause many diseases, like Friedreich ataxia, Parkinson's disease, chronic kidney disease, and psychological disorder (Sasmal et al, 2015 ). A SiO 2 PhC array was embedded in the hydrogel with L-His imprinted.…”

Seed-Assisted Effects on Solution-Mediated Phase Transformation: A Case Study of l-Histidine in Antisolvent Crystallization

“…It often serves as a precursor for many chemicals and is extensively used in many fields, such as food, pharmaceutical, and feed industries. Moreover, it has an important implication upon several biological activities, e.g., transmission of metal elements in biological bases and neurotransmitting or neuromodulating in the mammalian central nervous system. , …”

“…Moreover, it has an important implication upon several biological activities, e.g., transmission of metal elements in biological bases and neurotransmitting or neuromodulating in the mammalian central nervous system. 19,20 L-his is known to crystallize in two forms: A and B, with form A being stable. 20−27 Madden et al first reported the crystal structures of form A and form B in 1972.…”