Ultra-miniaturization of a planar amperometric sensor targeting continuous intradermal glucose monitoring

Ribet, Federico; Stemme, Göran; Roxhed, Niclas

doi:10.1016/j.bios.2016.10.007

Cited by 55 publications

(33 citation statements)

References 59 publications

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“…In our previous research, we have demonstrated the possibility to realize a sensor sufficiently small to fit inside a microneedle lumen, and hence in the dermal space, while preserving satisfactory stability, linearity, sensitivity, and selectivity in-vitro (Ribet et al 2017 , 2018 ). In this article, we characterize and demonstrate the possibility to perform in-situ minimally delayed and minimally invasive glucose monitoring in human skin in-vivo .…”

Section: Introductionmentioning

confidence: 99%

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Ribet

Stemme

Roxhed

2018

Biomed Microdevices

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133

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Continuous glucose monitoring (CGM) has the potential to greatly improve diabetes management. The aim of this work is to show a proof-of-concept CGM device which performs minimally invasive and minimally delayed in-situ glucose sensing in the dermal interstitial fluid, combining the advantages of microneedle-based and commercially available CGM systems. The device is based on the integration of an ultra-miniaturized electrochemical sensing probe in the lumen of a single hollow microneedle, separately realized using standard silicon microfabrication methods. By placing the sensing electrodes inside the lumen facing an opening towards the dermal space, real-time measurement purely can be performed relying on molecular diffusion over a short distance. Furthermore, the device relies only on passive capillary lumen filling without the need for complex fluid extraction mechanisms. Importantly, the transdermal portion of the device is 50 times smaller than that of commercial products. This allows access to the dermis and simultaneously reduces tissue trauma, along with being virtually painless during insertion. The three-electrode enzymatic sensor alone was previously proven to have satisfactory sensitivity (1.5 nA/mM), linearity (up to 14 mM), selectivity, and long-term stability (up to 4 days) in-vitro. In this work we combine this sensor technology with microneedles for reliable insertion in forearm skin. In-vivo human tests showed the possibility to correctly and dynamically track glycaemia over time, with approximately 10 min delay with respect to capillary blood control values, in line with the expected physiological lag time. The proposed device can thus reduce discomfort and potentially enable less invasive real-time CGM in diabetic patients.

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Section: Introductionmentioning

confidence: 99%

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Ribet

Stemme

Roxhed

2018

Biomed Microdevices

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133

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“…The as‐prepared nanofibers after calcination were suspended in ethanol for the preparation of transmission electron microscopy . Figure A reveals that the Co 3 O 4 NF is hollow and displays a spiral shape, thus possessing a large surface to volume ratio and favoring the electrochemical sensing.…”

Section: Resultsmentioning

confidence: 99%

Nitrogen‐doped Hollow Co₃O₄ Nanofibers for both Solid‐state pH Sensing and Improved Non‐enzymatic Glucose Sensing

et al. 2019

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Nitrogen‐doped hollow cobalt oxide nanofibers (Co3O4 NFs) with both glucose catalytic activity and pH sensitivity were fabricated through core‐sheath electrospinning technique, followed by calcination. The as‐developed nitrogen‐doped hollow Co3O4 NFs were thoroughly characterized using various techniques, and then employed to fabricate a dual electrochemical sensor for both pH sensing and glucose sensing. The pH sensitivity of the developed nitrogen‐doped hollow Co3O4 NFs demonstrated a Nernst constant of 12.9–15.9 mV/pH in the pH range of 3.0∼9.0 and 6.8–10.7 mV/pH in the pH range of 9.0∼13.0, respectively. The developed hollow cobalt oxides nanofibers sensor also possesses glucose sensitivity of 87.67 μA mM−1 cm−2, the limit of detection of 0.38 μM (S/N=3), and an acceptable selectivity against several common interferents in non‐enzymatic glucose determination. High accuracy for monitoring glucose in human serum sample was also demonstrated. These features indicate that the as‐synthesized nitrogen‐doped hollow cobalt oxides nanofibers hold great potential in the development of a unique dual sensor for both solid‐state pH sensing and superior non‐enzymatic glucose sensing.

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“…Voltammetric and amperometric sensors have been developed [ 102 , 103 , 104 , 105 , 106 , 107 ]. Amperometric sensors have found the widest application as they are the most sensitive, selective, and simple measuring devices.…”

Section: Sensors Characteristicsmentioning

confidence: 99%

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

et al. 2018

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Analytical chemistry is now developing mainly in two areas: automation and the creation of complexes that allow, on the one hand, for simultaneously analyzing a large number of samples without the participation of an operator, and on the other, the development of portable miniature devices for personalized medicine and the monitoring of a human habitat. The sensor devices, the great majority of which are biosensors and chemical sensors, perform the role of the latter. That last line is considered in the proposed review. Attention is paid to transducers, receptors, techniques of immobilization of the receptor layer on the transducer surface, processes of signal generation and detection, and methods for increasing sensitivity and accuracy. The features of sensors based on synthetic receptors and additional components (aptamers, molecular imprinted polymers, biomimetics) are discussed. Examples of bio- and chemical sensors’ application are given. Miniaturization paths, new power supply means, and wearable and printed sensors are described. Progress in this area opens a revolutionary era in the development of methods of on-site and in-situ monitoring, that is, paving the way from the “test-tube to the smartphone”.

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Ultra-miniaturization of a planar amperometric sensor targeting continuous intradermal glucose monitoring

Cited by 55 publications

References 59 publications

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Nitrogen‐doped Hollow Co₃O₄ Nanofibers for both Solid‐state pH Sensing and Improved Non‐enzymatic Glucose Sensing

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

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Ultra-miniaturization of a planar amperometric sensor targeting continuous intradermal glucose monitoring

Cited by 55 publications

References 59 publications

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

Nitrogen‐doped Hollow Co3O4 Nanofibers for both Solid‐state pH Sensing and Improved Non‐enzymatic Glucose Sensing

Sensors Based on Bio and Biomimetic Receptors in Medical Diagnostic, Environment, and Food Analysis

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Product

Resources

About

Nitrogen‐doped Hollow Co₃O₄ Nanofibers for both Solid‐state pH Sensing and Improved Non‐enzymatic Glucose Sensing